Cubs vs Reds Prediction 9/19/26 MLB Picks Today

In this article, we will formulate a Cubs vs Reds Prediction for this MLB matchup on Saturday, September 19^th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Cincinnati Reds Preview

The Cincinnati Reds have a 72-82 record this season and are sitting in the 5th place of the NL Central. They have a 38-41 home record and are coming off a 6-4 home win against the Cubs. They will face the Braves and the Blue Jays next.

The Cincinnati Reds have a .230 batting average this season, .307 OBP and .396 Slugging percentage. Cincinnati’s pitching staff has a 4.87 ERA and 1.45 WHIP. Elly De La Cruz is the team’s best hitter with a .287 batting average. Sal Stewart leads the team in RBI with 110, adding a team-high 32 home runs.

Nick Lodolo (L) is the projected starting pitcher for the Reds, and he has a 3-5 record, 5.12 ERA and 1.49 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 85-69 record this season and are sitting in the 2nd place of the NL Central. They have a 40-36 away record and are coming off a 4-6 road loss against the Reds. They will face the Marlins and the Red Sox next.

The Chicago Cubs have a .252 batting average this season, .340 OBP and .431 Slugging percentage. Chicago’s pitching staff has a 4.21 ERA and 1.27 WHIP. Pete Crow-Armstrong is the team’s best hitter with a .280 batting average, leading the team in RBI with 105 and adding a team-high 44 home runs.

Matthew Boyd (L) is the projected starting pitcher for the Cubs, and he has a 8-5 record, 4.16 ERA and 1.24 WHIP.

The Chicago Cubs @ Cincinnati Reds Betting Trends: September 19, 2026

• Probable Starting Pitcher: Nick Lodolo      Record this season: 3-5      ERA: 5.12
• Home Record: 2-3
• Last 5 against Cubs: 0-0

Why the Cincinnati Reds will win

• The Reds have won each of their last three games as home underdogs against NL Central opponents.
• The Cubs have lost each of their last five road games.
• The Cubs have failed to cover the run line each of their last four games against teams that held a losing record.
• The underdogs have covered the run line in four of the Cubs’ last five games at Great American Ball Park.
• The Reds have led after 5 innings in nine of their last 12 night games against the Cubs at Great American Ball Park.
• The Cubs have trailed after 3 innings in five of their last six night games against opponents that held a losing record.
• The Cubs have lost the first inning in four of their last five games against NL Central opponents.

• Probable Starting Pitcher: Matthew Boyd      Record this season: 8-5      ERA: 4.16
• Road Record: 3-2
• Last 5 against Reds: 2-2

Why the Chicago Cubs will win

• The Reds have lost each of their last six night games following a win.
• The Cubs have won each of their last six Saturday road games against NL opponents.
• The Reds have failed to cover the run line in each of their last 12 night games following a win.
• The Cubs have covered the run line each of their last seven Saturday night games against NL Central opponents that held a losing record.
• The Cubs have led after 5 innings in each of their last seven games.
• The Reds have trailed after 3 innings in seven of their last nine games.
• The Cubs have won the first inning in four of their last five games against the Reds.

Total Runs Facts

• Seven of the Cubs’ last eight games as favorites against the Reds have gone OVER the total runs line.
• Each of the last five games between the Cubs and Reds have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the Cubs’ last six games against NL Central opponents.
• There has been at least one run scored in the first inning in each of the Reds’ last six night games against NL Central opponents.

Cincinnati Reds Player Prop Facts

• Sal Stewart has hit a home run in three of the Reds’ last four games against the Cubs.
• Nick Lodolo has recorded six or more strikeouts in each of his four previous appearances with the Reds as home underdogs against NL Central opponents.
• Sal Stewart has recorded at least one hit in each of the Reds’ last 28 games against NL Central opponents that held a winning record.
• Elly De La Cruz ranks 9th amongst qualified players for Slugging Percentage (.519) this season.

Chicago Cubs Player Prop Facts

• Matthew Boyd has recorded five or more strikeouts in nine of his 10 previous appearances in night games against NL Central teams that held a losing record.
• Seiya Suzuki has recorded at least one hit in each of the Cubs’ last nine games at Great American Ball Park against opponents that held a losing record.
• Ian Happ has hit a home run in three of his last four road appearances against opponents that held a losing record.
• Pete Crow-Armstrong ranks 2nd in the league in Home Runs (44) this season.

Matchup/League Facts

• The Reds rank 30th in the league for hits this season (1176).
• The Reds rank 30th in the league for batting average this season (.230).
• The Cubs rank 1st in the league for runs scored this season (821).
• The Cubs rank 1st in the league for home runs this season (212).

Cubs vs Reds Prediction

The Reds are 3-1 in their last 4 meetings against the Cubs but have lost two of their last three meetings in Cincinnati.

In this Cubs vs Reds Prediction, the Cubs are coming as -135 road favorites. I don’t like the pitching in this matchup as both starters have a combined 9.28 ERA and they both have been in terrible form. Their expected numbers are even worse and both teams are better against left-handed pitching, averaging 10.2 runs per game against southpaws this season, with the Cubs having the best offense in baseball. The opening game of this series had 10 total runs, so take the over 9.5 in this one.