Cubs vs Reds Prediction 5/6/26 MLB Picks Today

In this article we will formulate a Cubs vs Reds prediction for this MLB game on Wednesday, May 6th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 24-12 this year after they won the first two games in this series by scores of 5-4 and 3-2. In game two, Chicago erased a 2-0 deficit and got the win in extra innings. The Cubs recorded eight hits and they committed one error in the game, while they were led by Busch, who went 3-4 with one home run and two RBIs. Taillon allowed five hits and two earned runs over 5.2 innings, while Rolison picked up the win in relief. Prior to this series, Chicago swept the Diamondbacks in three games and won two out of three against the Padres. 

This season, Chicago has a 3.83 ERA with a 1.17 WHIP and a .227 opponent batting average, while they have scored 193 runs with a .258 batting average and a .352 on base percentage. Nico Hoerner has led the Cubs with four home runs and 27 RBIs, while Dansby Swanson has added six home runs and 24 RBIs. The projected starting pitcher for Chicago is Colin Rea, who is 4-1 with a 4.41 ERA and a 1.32 WHIP over 32.2 innings pitched this year. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 20-16 this season after they lost game two by a score of 3-2 in extra innings. Cincinnati led 2-0 in the sixth inning, but they allowed a run in the seventh and eighth, before failing to score in the 10th for the loss. The Reds recorded six hits and they committed one error in the game, while they were led by Bleday, who went 1-4 with one home run and one RBI. Abbott allowed four hits and zero earned runs over 5.2 innings, while Moll picked up the loss in relief. Prior to this series, Cincinnati lost all three against the Pirates, but did win two out of three against the Rockies before that. 

This season, Cincinnati has a 4.45 ERA with a 1.50 WHIP and a .253 opponent batting average, while they have scored 147 runs with a .218 batting average and a .303 on base percentage. Sal Stewart has led the Reds with nine home runs and 29 RBIs, while Elly De La Cruz has added 10 home runs and 25 RBIs. The projected starting pitcher for Cincinnati is Brady Singer, who is 2-2 with a 5.57 ERA and a 1.73 WHIP over 32.1 innings pitched this season. 

Why the Chicago Cubs will win

• The Cubs have won each of their last 13 home games.
• The Reds have lost each of their last seven games against NL Central opponents.
• The Reds have failed to cover the run line each of their last six Wednesday games against NL Central opponents that held a winning record.
• The Cubs have covered the run line in four of their last five night games after going to extra innings.
• The Cubs have led after 3 innings in each of their last six Wednesday games as home favorites.
• The Cubs have led after 5 innings in each of their last six Wednesday games as home favorites.

Why the Cincinnati Reds will win

• The Reds have won three of their last four games as underdogs after going to extra innings.
• The Reds have covered the run line each of their last seven night games against teams that held a winning record.
• The Cubs have failed to cover the run line in each of their last six games against NL Central opponents.
• The Reds have led after 3 innings in each of their last four games against the Cubs.
• The Reds have led after 5 innings in three of their last four games against the Cubs.

Total Runs Facts

• Ten of the last 11 games between the Reds and Cubs at Wrigley Field have gone UNDER the total runs line.
• Nine of the Reds’ last 10 games following an extra innings loss have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of Colin Rea’s 10 previous appearances as a starter against the Reds.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the Reds’ last 14 games at Wrigley Field.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit a home run in four of the Cubs’ last seven night games.
• Alex Bregman has recorded at least one hit in each of his last six appearances against NL Central opponents.
• Colin Rea ranks T9th in the league for Wins (4) this season.

Cincinnati Reds Player Prop Facts

• JJ Bleday has hit a home run in three of the Reds’ last four games.
• Brady Singer has recorded a win in three of his last four appearances in night games against teams that held a winning record.
• Brady Singer has recorded four or more strikeouts in 11 of his 12 previous appearances in night games against NL teams that held a winning record.
• Spencer Steer has recorded at least one hit in each of the Reds’ last 10 road games.
• Elly De La Cruz ranks T10th in the league in Home Runs (10) this season.

Matchup/League Facts

• The Cubs rank 1st in the league for on-base percentage this season (.352).
• The Cubs rank 1st in the league for walks this season (168).
• The Reds rank 30th in the league for hits this season (260).
• The Reds rank 30th in the league for batting average this season (.218).

Cubs vs Reds Prediction 

Chicago comes into this matchup on a seven game winning streak and they continue to pile up wins at home. The Cubs are 16-5 at home this year, while the Reds are 10-8 on the road. Cincinnati has lost five games in a row and they have scored two runs or fewer in three of those five loss. The Reds are starting Singer, who has allowed 3+ earned runs in three of his last five starts, while Rea has allowed 2, 1, 6, and 3 earned runs in his last four outings. I know the Cubs are hot right now, but they were very lucky to win the first two games in this series, so I think there is some value with the Reds. Take Cincinnati to win here.