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Cubs vs Reds Prediction 6/1/25 MLB Picks Today

Cincinnati Reds (29-30) vs. Chicago Cubs (36-22)
June 1, 2025 2:20 pm EDT
The Line: Chicago Cubs -162 / Cincinnati Reds 136; Over/Under: 7.5
(Get latest betting odds)

In this article, we will formulate a Cubs vs Reds prediction for this MLB game on Sunday, June 1, at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

Cincinnati Reds Betting Preview

The Cincinnati Reds (29-30, 15-16 Away) lost a series to the Pirates and Cubs, but bounced back with a win against the Kansas City Royals. The Reds opened the current series against the Cubs with a 6-2 win, but lost Game 2 on Saturday. In that 2-0 defeat, Nick Lodolo pitched for 6.0 innings in a no-decision, allowing no runs on five hits with five strikeouts and two walks. Graham Ashcraft took the loss.

This season, the Reds average 4.58 runs per game (9th in the MLB) on a .246/.301/.361 triple-slash. When it comes to pitching, the Reds’ staff has a 3.72 ERA (11th) and 1.18 WHIP (6th). Elly De La Cruz leads the Reds with a .252 batting average, 11 home runs, and 40 RBI this season.

Nick Martinez will take the mound for the Reds on Sunday. The 27-year-old left-hander has a 3-5 record in 11 starts this year with a 3.48 ERA and 1.11 WHIP in 64.2 innings.

Chicago Cubs Betting Preview

The Chicago Cubs (36-22, 19-11 Home) won six previous series, defeating the Miami Marlins twice, the Cincinnati Reds, and the Colorado Rockies, among others. After losing Game 1 to the Reds, the Cubs answered with a 2-0 win on Saturday. Ben Brown pitched for 6.0 innings in a no-decision, allowing no runs on one hit with nine strikeouts and one walk. Brad Keller was credited with the win.

This year, the Cubs average 5.76 runs per game (2nd in the MLB) on a .261/.335/.447 triple-slash. When it comes to pitching, the Cubs’ staff has a 3.85 ERA (14th) and 1.26 WHIP (16th). Seiya Suzuki leads the Cubs with a .273 batting average, 14 home runs, and 52 RBI this season.

The projected starting pitcher for the Cubs is Jameson Taillon, who is 4-3 in 11 starts this season, with a 3.86 ERA and 1.05 WHIP in 63.0 innings.

Total Runs Facts

  • Fourteen of the Reds’ last 16 road games against NL Central opponents have gone UNDER the total runs line.
  • Each of the last five games between the Reds and Cubs at Wrigley Field have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Reds’ last eight day games at Wrigley Field.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the last eight games between the Reds and Cubs at Wrigley Field.

Matchup/League Facts

  • The Cubs rank 2nd in the league for doubles this season (111).
  • The Cubs rank 2nd in the league for triples this season (14).
  • The Reds rank T6th in the league for doubles this season (101).
  • The Reds rank 7th in the league for opponent batting average this season (.230).

Cubs vs Reds Prediction

The Cubs won six of the previous ten H2H encounters, including three of five duels this season. Four of those five clashes produced 8+ runs, and that is one of the reasons I am going with Over in this one. Jameson Taillon was excellent in his last two starts, but he did allow ten runs in three starts before. Nick Martinez, on the other hand, had an even better month (May) than Taillon, but it won’t be easy for him against one of the best offenses in the MLB. Go with Over.

Oliver Zivic's Free Pick: Over 7.5

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Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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