Cubs vs White Sox Prediction 5/17/26 MLB Picks Today

In this article, we will formulate a Cubs vs White Sox Prediction for this MLB matchup on Sunday, May 17^th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Preview

The Chicago White Sox have a 23-22 record this season and are sitting in the second place of the AL Central. They have a 13-10 home record and are coming off a 8-3 win against the Cubs. They will face the Mariners and the Giants next.

The White Sox have a .234 batting average this season, .324 OBP and .409 Slugging percentage. Chicago’s pitching staff has a 4.32 ERA and 1.37 WHIP. Munetaka Murakami is the team’s best hitter with a .236 batting average, also leading the team in RBI with 32. Munetaka Murakami adds a team high 17 home runs.

Erick Fedde (R) is the projected starting pitcher for the White Sox, and he has a 0-4 record, 3.77 ERA and 1.16 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 29-17 record this season and are sitting in the first place of the NL Central. They have a 11-12 away record and are coming off a 8-3 loss against the White Sox. They will face the Mariners and the Giants next.

The Cubs have a .247 batting average this season, .341 OBP and .406 Slugging percentage. Chicago’s pitching staff has a 3.90 ERA and 1.19 WHIP. Nico Hoerner is the team’s best hitter with a .262 batting average, also leading the team in RBI with 29. Ian Happ adds a team high 10 home runs.

Colin Rea (R) is the projected starting pitcher for the Cubs, and he has a 4-2 record, 4.68 ERA and 1.42 WHIP.

The Chicago Cubs @ the Chicago White Sox Betting Trends: May 17, 2026

• Probable Starting Pitcher: Erick Fedde      Record this season: 0-4      ERA: 3.77
• Home Record: 0-1
• Last 5 against Cubs: 0-3

Why the Chicago White Sox will win

• The White Sox have won seven of their last eight games as home underdogs after playing the previous day.
• The Cubs have lost three of their last four games as favorites.
• The White Sox have covered the run line in each of their last nine Sunday games as home underdogs.
• The Cubs have failed to cover the run line in each of their last six day games following a loss.
• The White Sox have won the first inning in three of their last four day games against NL Central opponents.
• The White Sox have led after 3 innings in five of their last six day games against opponents that held a winning record.
• The White Sox have led after 5 innings in four of their last five games.

• Probable Starting Pitcher: Colin Rea      Record this season: 4-2      ERA: 4.68
• Road Record: 2-2
• Last 5 against White Sox: 0-0

Why the Chicago Cubs will win

• The White Sox have lost 17 of their last 18 day games against NL Central opponents that held a winning record.
• The Cubs have won each of their last eight day games against AL Central opponents following a loss.
• The White Sox have failed to cover the run line in each of their last six home games against National League opponents following a win.
• The Cubs have covered the run line in each of their last six road games against the White Sox following a road loss.
• The Cubs have led after 3 innings in each of their last four day games against the White Sox.
• The White Sox have trailed after 5 innings in nine of their last 11 day games at Rate Field against NL Central opponents.

Total Runs Facts

• Each of the White Sox’s last five games have gone OVER the total runs line.
• Five of the Cubs’ last six games as favorites against the White Sox have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 13 of the White Sox’s last 14 day games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cubs’ last six day games against American League opponents.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in each of the White Sox’s last three home games against opponents that held a winning record.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last 18 games as underdogs.
• Munetaka Murakami ranks 2nd in the league in Home Runs (17) this season.

Chicago Cubs Player Prop Facts

• Alex Bregman has recorded at least one hit in each of his last nine road appearances.
• Michael Conforto has hit a home run in each of his last two road appearances against the White Sox after playing the previous day.
• Pete Crow-Armstrong ranks 10th in the league in Steals (11) this season.

Matchup/League Facts

• The White Sox rank 30th in the league for doubles this season (53).
• The White Sox rank T2nd in the league for home runs this season (64).
• The Cubs rank 1st in the league for walks this season (212).
• The Cubs rank 2nd in the league for on-base percentage this season (.341).

Cubs vs White Sox Prediction

The Cubs are 8-2 in their last 10 meetings against the White Sox and are 3-1 in their last 4 road meetings.

In this Cubs vs White Sox Prediction, the Cubs are coming as -140 road favorites. The White Sox won yesterday and they have the pitching edge today as Erick Fedde goes up against Colin Rea. Fedde has a 2.41 home ERA while Rea a terrible 6.55 road ERA and the White Sox have been hitting righties much better in the past couple of weeks, with the Cubs ranking just 22^nd in batting against right-handed pitching. I like the value with the home dog in this spot, so take the White Sox on the moneyline in this one.