Cubs vs White Sox Prediction 7/25/25 MLB Picks Today

In this article, we will formulate a Cubs vs White Sox Prediction for this MLB game on Friday, July 25^th at the Rate Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Preview

The Chicago White Sox have a 37-66 record this season and are sitting on the last place of the AL Central. The White Sox have a 21-29 home record and are 45-53 in over/under. They are coming off a 11-9 road victory over the Rays, and are 5-1 in their last 6 games. Over is 5-2 in their last 7 games and are playing the Phillies and the Angels next.

The White Sox have a .224 batting average this season, .298 OBP and .354 Slugging percentage. Chicago’s pitching staff has a 4.08 ERA and 1.38 WHIP. Lenyn Sosa leads the White Sox with 81 hits, while Luis Robert Jr. leads the team in RBI with 41. Chase Meidroth is the team’s best hitter with a .250 batting average, while Miguel Vargas adds a team-high 12 home runs.

Adrian Houser (R) is the projected starter for the White Sox, and he has a 5-2 record, 1.89 ERA and 1.23 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 60-42 record this season and are sitting on the second place of the NL Central. The Cubs have a 27-23 road record and are 50-43 in over/under. They are coming off a 4-8 home defeat by the Royals, and are 1-3 in their last 4 games. Over is 3-1 in their last 4 games, and are playing the Orioles and the Brewers next.

The Cubs have a .256 batting average this season, .324 OBP and .446 Slugging percentage. Chicago’s pitching staff has a 3.86 ERA and 1.22 WHIP. Nico Hoerner leads the Cubs with 107 hits, and he is the team’s best hitter with a .286 batting average. Seiya Suzuki leads the team in RBI, with 81, while Pete Crow-Armstrong adds a team-high 27 home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 7-3 record, 2.40 ERA and 0.92 WHIP.

Why the Chicago White Sox will win

• The White Sox have won each of their last four games as underdogs against National League opponents.
• The Cubs have lost each of their last five road games against American League opponents following a home loss.
• The White Sox have covered the run line in each of their last seven games.
• The Cubs have failed to cover the run line in five of their last six night games against AL Central opponents.
• The Cubs have trailed after 3 innings in each of their last five road night games.
• The Cubs have trailed after 5 innings in nine of their last 11 road night games.
• The Cubs have lost the first inning in three of their last four road games against AL Central opponents.

Why the Chicago Cubs will win

• The White Sox have lost each of their last 19 night games against National League opponents that held a winning record.
• The Cubs have won each of their last eight games against the White Sox.
• The road team has covered the run line in each of the White Sox’s last six games.
• The White Sox have failed to cover the run line in eight of their last nine night games against National League opponents that held a winning record.
• The White Sox have trailed after 3 innings in each of their last six games against NL Central opponents that held a winning record.
• The White Sox have trailed after 5 innings in five of their last six night games against opponents that held a winning record.

Total Runs Facts

• Each of the Cubs’ last eight road games against AL Central opponents have gone UNDER the total runs line.
• Five of the White Sox’s last six night games as underdogs have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight games as underdogs against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the Cubs’ last 14 night games against AL Central opponents.

Matchup/League Facts

• The White Sox rank 30th in the league for batting average this season (.224).
• The White Sox rank 29th in the league for hits this season (756).
• The Cubs rank 2nd in the league for runs scored this season (537).
• The Cubs rank 2nd in the league for RBIs this season (525).

Cubs vs White Sox Prediction

The Cubs have won their last 8 meetings against the White Sox, and have won their last three visits in Rate Field. Over is 5-1-1 in their last 7 meetings.

In this Cubs vs White Sox Prediction, the Cubs are coming as -180 road favorites. The Cubs are rightfully favored, as they have a superior overall record, and have been above average on the road. Houser has been lights out for the White Sox, as he boasts an insane 0.69 home ERA. Imanaga has also been better on the road, with a 1.33 road ERA, and both pitchers have been in excellent form lately, with a combined 3.43 ERA in their last five starts. I like both pitchers to suppress the opposing offenses, so take the under 4.5 runs in the first 5 innings of this game.