Diamondbacks vs Astros Prediction 9/6/26 MLB Picks Today

In this article, we will formulate a Diamondbacks vs Astros Prediction for this MLB matchup on Sunday, September 6^th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Preview

The Houston Astros have a 73-70 record this season and are sitting in the 1st place of the AL West. They have a 37-37 home record and are coming off a 3-4 home loss against the Diamondbacks. They will face the Phillies and the Rays next.

The Houston Astros have a .240 batting average this season, .315 OBP and .408 Slugging percentage. Houston’s pitching staff has a 4.52 ERA and 1.35 WHIP. Yordan Alvarez is the team’s best hitter with a .315 batting average, leads the team in RBI with 94, and adds a team-high 37 home runs.

Peter Lambert (R) is the projected starting pitcher for the Astros, and he has an 8-7 record, 3.66 ERA and 1.24 WHIP.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 75-68 record this season and are sitting in the 2nd place of the NL West. They have a 34-37 away record and are coming off a 4-3 road win against the Astros. They will face the Royals and the Rangers next.

The Arizona Diamondbacks have a .242 batting average this season, .314 OBP and .394 Slugging percentage. Arizona’s pitching staff has a 4.14 ERA and 1.28 WHIP. Gabriel Moreno is the team’s best hitter with a .300 batting average and also leads the team in RBI with 69, while Ketel Marte adds a team-high 22 home runs.

Eduardo Rodriguez (L) is the projected starting pitcher for the Diamondbacks, and he has a 14-5 record, 2.59 ERA and 1.22 WHIP.

Arizona Diamondbacks @ Houston Astros Betting Trends: September 6, 2026

• Probable Starting Pitcher: Peter Lambert      Record this season: 8-7      ERA: 3.66
• Home Record: 5-5
• Last 5 against Diamondbacks: 2-1

Why the Houston Astros will win

• The Astros have won each of their last six home games against the Diamondbacks following a loss.
• The Diamondbacks have lost each of their last five road games against the Astros following a win.
• The Astros have covered the run line in 11 of their last 12 home games against teams that held a winning record.
• The Diamondbacks have failed to cover the run line in five of their last six road games against teams that held a winning record.
• The Diamondbacks have trailed after 5 innings in each of their last seven road games against AL West opponents.
• The Diamondbacks have trailed after 3 innings in each of their last nine games against AL opponents.

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 14-5      ERA: 2.59
• Road Record: 6-1
• Last 5 against Astros: 0-4

Why the Arizona Diamondbacks will win

• The Astros have lost each of their last 11 games as favorites after going to extra innings.
• The Diamondbacks have won seven of their last eight games as underdogs after going to extra innings.
• The Astros have failed to cover the run line in each of their last 16 games as favorites after going to extra innings.
• The Diamondbacks have covered the run line in each of their last seven day games against AL West opponents following a win.
• The Astros have trailed after 3 innings in each of their last four day games against NL West opponents.
• The Astros have lost the first inning in three of their last four day games against NL opponents.
• The Astros have trailed after 5 innings in each of their last five day games against NL opponents.

Total Runs Facts

• Each of the Astros’ last five games have gone UNDER the total runs line.
• Each of the Diamondbacks’ last four road games against AL West opponents have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Astros’ last six day games.
• There has been no run scored during the first inning in each of the Diamondbacks’ last five games at Daikin Park.

Houston Astros Player Prop Facts

• Jeremy Pena has hit a home run in three of the Astros’ last four games as home favorites against NL opponents.
• Peter Lambert has recorded a win in four of his last five appearances in day games against teams that held a winning record.
• Peter Lambert has recorded six or more strikeouts in four of his last five appearances with the Astros as favorites.
• Isaac Paredes has recorded at least one hit in each of the Astros’ last 18 home games against opponents that held a winning record.
• Yordan Alvarez ranks 1st amongst qualified players for Slugging Percentage (.597) this season.

Arizona Diamondbacks Player Prop Facts

• Eduardo Rodriguez has recorded a win in each of his last four road appearances.
• Eduardo Rodriguez has recorded five or more strikeouts in each of his last eight Sunday appearances against AL teams that held a winning record.
• Gabriel Moreno has recorded at least one hit in each of his last eight appearances against AL West opponents.
• James McCann has hit a home run in each of his last two appearances against AL West opponents.
• Eduardo Rodriguez ranks T5th in the league for Wins (14) this season.

Matchup/League Facts

• The Astros rank 30th in the league for walks allowed this season (591).
• The Astros rank T29th in the league for steals this season (43).
• The Diamondbacks rank 1st in the league for triples this season (35).
• The Diamondbacks rank 29th in the league for strikeouts this season (979).

Diamondbacks vs Astros Prediction

The Astros are 8-2 in their last 10 meetings against the Diamondbacks but have lost two of their last three meetings in Houston.

In this Diamondbacks vs Astros Prediction, both teams are coming at a pickem price. I like the under in this one, as both offenses have been struggling lately, scoring just 4.7 runs combined in their last five games. Both pitchers have been good, as Rodriguez has two shutouts in his last three starts and Lambert has a 3.66 ERA this season. Both bullpens have also been in good shape lately with a combined 5.53 ERA in their last 10 starts and both games in this series had 7 and 4 total runs. Take the under 8 in this one.