Diamondbacks vs Astros Prediction 9/5/26 MLB Picks Today

In this article, we will formulate a Diamondbacks vs Astros Prediction for this MLB matchup on Saturday, September 5^th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Preview

The Houston Astros have a 73-69 record this season and are sitting in 1st place in the AL West. They have a 37-36 home record and are coming off a 3-1 home win against the Diamondbacks. They will face the Phillies and the Rays next.

The Houston Astros have a .240 batting average this season, .315 OBP, and .408 slugging percentage. Houston’s pitching staff has a 4.53 ERA and 1.36 WHIP. Yordan Alvarez is the Astros’ best hitter with a .317 batting average, while leading the team in RBI with 94, adding a team-high 37 home runs.

Ethan Pecko (R) is the projected starting pitcher for the Astros, with a 1-0 record, 6.23 ERA, and 1.54 WHIP.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 74-68 record this season and are sitting in 3rd place in the NL West. They have a 33-37 road record and are coming off a 1-3 road loss against the Astros. They will face the Royals and the Rangers next.

The Arizona Diamondbacks have a .242 batting average this season, .314 OBP, and .394 slugging percentage. Arizona’s pitching staff has a 4.15 ERA and 1.28 WHIP. Gabriel Moreno is the Diamondbacks’ best hitter with a .299 batting average, while leading the team in RBI with 68, adding a team-high 21 home runs.

Brandon Pfaadt (R) is the projected starting pitcher for the Diamondbacks, with a 7-2 record, 3.49 ERA, and 1.14 WHIP.

Arizona Diamondbacks @ Houston Astros Betting Trends: September 5, 2026

• Probable Starting Pitcher: Ethan Pecko      Record this season: 1-0      ERA: 6.23
• Home Record: 0-0
• Last 5 against Diamondbacks: –

Why the Houston Astros will win

• The Diamondbacks have lost each of their last six road games against AL West opponents.
• The Astros have won nine of their last 10 games against the Diamondbacks.
• The Diamondbacks have failed to cover the run line in each of their last six night games against AL West opponents.
• The Astros have covered the run line in 10 of their last 11 home games against teams that held a winning record.
• The Diamondbacks have trailed after 3 innings in each of their last eight games against AL opponents.
• The Diamondbacks have trailed after 5 innings in each of their last seven night games against opponents that held a winning record.

• Probable Starting Pitcher: Brandon Pfaadt      Record this season: 7-2      ERA: 3.49
• Road Record: 4-1
• Last 5 against Astros: 0-1

Why the Arizona Diamondbacks will win

• The Diamondbacks have won three of their last four games as underdogs after playing the previous day.
• The Astros have lost five of their last seven games as favorites following a home win.
• The Diamondbacks have covered the run line each of their last six Saturday games against teams that held a winning record.
• The Astros have failed to cover the run line in each of their last six Saturday night games as home favorites against NL opponents.
• The Astros have trailed after 5 innings in eight of their last nine games against NL opponents.
• The Astros have trailed after 3 innings in each of their last six Saturday night games as favorites.

Total Runs Facts

• Seven of the last eight games between the Diamondbacks and Astros at Daikin Park have gone OVER the total runs line.
• Each of the Diamondbacks’ last four games as underdogs against AL West opponents have gone UNDER the total runs line.
• There has been no run scored during the first inning in each of the Astros’ last six night games.
• There has been no run scored during the first inning in each of the Diamondbacks’ last four games at Daikin Park.

Houston Astros Player Prop Facts

• Jeremy Pena has hit a home run in three of the Astros’ last four home games against NL opponents.
• Isaac Paredes has recorded at least one hit in each of the Astros’ last 17 home games against opponents that held a winning record.
• Yordan Alvarez ranks 1st amongst qualified players for Batting Average (.317) this season.

Arizona Diamondbacks Player Prop Facts

• Ketel Marte has hit a home run in three of the Diamondbacks’ last four night games against AL West opponents that held a winning record.
• Brandon Pfaadt has recorded five or more strikeouts in four of his last five road appearances against AL West opponents.
• Gabriel Moreno has recorded at least one hit in each of the Diamondbacks’ last seven games as road underdogs.
• Gabriel Moreno ranks 8th amongst qualified players for Batting Average (.299) this season.

Matchup/League Facts

• The Astros rank 30th in the league for walks allowed this season (588).
• The Astros rank T29th in the league for steals this season (43).
• The Diamondbacks rank 1st in the league for triples this season (35).
• The Diamondbacks rank 29th in the league for strikeouts this season (969).

Diamondbacks vs Astros Prediction

The Astros are 9-1 in their last 10 meetings against the Diamondbacks and are 3-1 in their last 4 meetings in Houston.

In this Diamondbacks vs Astros Prediction, both teams are coming at a pickem price. The Dbacks’ offense has been ice-cold lately, as they have scored just one run in their last four games and with Brandon Pfaadt struggling lately with 11 earned runs in his last three starts, they are simply unbackable. I don’t really trust Ethan Pecko, but the Astros have been in good form with a 7-2 record in their last 9 games and are scoring more runs than the Dbacks. Take the Astros in this one.