Diamondbacks vs Cubs Prediction 3/29/25 MLB Picks Today

In this article, we will formulate a Diamondbacks vs Cubs prediction for this MLB game on Saturday, March 29th, at Chase Field in Phoenix, Arizona. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Betting Preview

The Chicago Cubs finished the last season with an 83-79 record and in 2nd place in the NL Central, ten wins behind the champions Milwaukee Brewers. The Cubs already played four games this season and have a 1-3 record; they lost two games to the Dodgers in Tokyo, defeated the Diamondbacks 10-6 in the opening game of the series, and then lost 8-1 to the D-backs.

Last season, the Cubs averaged 4.54 runs per game (12th in the MLB) on a .242/.317/.393 triple-slash. When it comes to pitching, Chicago’s staff had a 4.13 ERA (9th) and 1.2 WHIP (15th). Ian Happ led the Cubs with a .243 batting average, 25 home runs, and 86 RBI last season.

The projected starting pitcher for the Cubs is Shota Imanaga, who went 15-3 with a 2.91 ERA and a 1.02 WHIP over 173.1 innings pitched in 2024. Imanaga has one start this year, a no-decision over 4.0 innings against the Dodgers.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks ended the last season in 2nd place in the NL West with an 89-73 record, nine wins behind the Dodgers. However, the D-backs missed out on the playoffs as they had a worse H2H record against the Mets and Braves, who both went to the Wild Card round. Arizona opened this season with a 10-6 loss to the Cubs bout bounced back with an 8-1 victory. Eugenio Suarez erupted for four RBI and two home runs, while Merrill Kelly got a win after allowing one run on three hits with one strikeout and four walks in 5.1 innings.

Last year, the Diamondbacks averaged 5.47 runs per game (1st in the MLB) on a .263/.337/.440 slash line. The Diamondbacks’ pitching staff had a 4.86 ERA (28th) and 1.35 WHIP (29th). Ketel Marte was the best offensive player for the D-backs, with a .292 batting average, 36 home runs, and 95 RBI last season.

Brandon Pfaadt will take the mound for the Diamondbacks on Saturday. The 26-year-old right-hander had an 11-10 record in 2024 with a 4.71 ERA and 1.24 WHIP over 181.2 innings.

Why the Cubs will beat the Diamondbacks

• The Diamondbacks have lost each of their last five games as favorites against the Cubs following a home win.
• The Cubs have won each of their last four games as underdogs against the Diamondbacks following a road loss.
• The Cubs have covered the run line in each of their last seven games as underdogs against National League opponents following a road loss.
• The Diamondbacks have failed to cover the run line in each of their last six games as favorites against the Cubs following a home win.

Why the Diamondbacks will beat the Cubs

• The Cubs have lost each of their last seven Saturday night games against NL West opponents.
• The favorites have won seven of the Cubs’ last eight games.
• The Cubs have failed to cover the run line in six of their last seven night games against NL West opponents.
• The Diamondbacks have covered the run line in five of their last six games against NL Central opponents.
• The Diamondbacks have led after 5 innings in three of their last four games against NL Central opponents.
• The Cubs have lost the first inning in three of their last four road games.

Total Runs Facts

• Eight of the Cubs’ last 10 games as road underdogs have gone OVER the total runs line.
• Three of the Diamondbacks’ last four home games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cubs’ last seven games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the last 10 night games between the Cubs and Diamondbacks at Chase Field.

Diamondbacks vs Cubs Prediction

The Diamondbacks won six of the previous ten H2H encounters, but the Cubs won three of the last five. Even though the opening two games of this series produced a bunch of runs, I am going with Under here because Under hit in six of the last ten H2Hs. Imanaga was excellent in his previous start against the D-backs; he had a 1.29 ERA in 7.0 innings. Pfaadt started two games against the Cubs last year and posted a 1.29 ERA over 14.0 innings. Expect a strong display from these pitchers and back Under.