Diamondbacks vs Cubs Prediction 8/25/26 MLB Picks Today
Chicago Cubs (76-56) vs. Arizona Diamondbacks (69-63)
August 25, 2026 9:40 pm EDT
The Line: Arizona Diamondbacks -102 / Chicago Cubs -105; Over/Under: 8
(Get latest betting odds)
The Chicago Cubs and Arizona Diamondbacks meet Tuesday in MLB action at Chase Field. Here’s a Diamondbacks vs Cubs Prediction. This article will include a Diamondbacks vs Cubs Pick.
Chicago Cubs Betting Preview
The Chicago Cubs are 76-56 on the year and play the Reds and Brewers next. The Chicago Cubs are batting .250 on the season and have a .339 OBP and a .424 slugging percentage. The Chicago Cubs’ pitching staff has a 4.09 ERA and a 1.25 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 140 hits and 83 RBI, while Alex Bregman and Nico Hoerner have combined for 265 hits and 128 RBI.
Clay Holmes gets the ball for the Chicago Cubs, and he is 5-6 with a 2.49 ERA and 50 strikeouts this season. Holmes is 1-1 with a 4.97 ERA and 12 strikeouts in his career against the Arizona Diamondbacks.
Arizona Diamondbacks Betting Preview
The Arizona Diamondbacks are 69-63 on the year and play the Phillies and Giants next. The Arizona Diamondbacks are batting .244 on the season and have a .317 OBP and a .399 slugging percentage. The Arizona Diamondbacks’ pitching staff has a 4.21 ERA and a 1.30 WHIP. Corbin Carroll leads the Arizona Diamondbacks with 120 hits and 58 RBI, while Ketel Marte and Geraldo Perdomo have combined for 230 hits and 111 RBI.
Brandon Pfaadt gets the ball for the Arizona Diamondbacks, and he is 7-1 with a 3.39 ERA and 69 strikeouts this season. Pfaadt is 1-2 with a 2.94 ERA and 29 strikeouts in his career against the Chicago Cubs.
Why the Arizona Diamondbacks will win
- The Diamondbacks have won each of their last six games as underdogs following a home loss.
- The Cubs have lost six of their last nine games as road favorites against NL West opponents following a road win.
- The Diamondbacks have covered the run line in each of their last seven games as underdogs against NL opponents following a loss.
- The Cubs have failed to cover the run line in eight of their last 10 games as road favorites against NL West opponents following a win.
- The Cubs have trailed after 3 innings in four of their last five road night games.
Why the Chicago Cubs will win
- The Cubs have won each of their last 11 games against NL West opponents that held a winning record.
- The Diamondbacks have lost each of their last four night games after playing the previous day.
- The Cubs have covered the run line in each of their last nine night games against NL opponents.
- The Diamondbacks have failed to cover the run line in four of their last five games as underdogs.
- The Cubs have led after 3 innings in each of their last eight games against the Diamondbacks.
- The Cubs have won the first inning in three of their last four night games.
- The Cubs have led after 5 innings in eight of their last nine games against the Diamondbacks.
Total Runs Facts
- Seven of the Diamondbacks’ last eight games as home underdogs have gone UNDER the total runs line.
- Each of the Cubs’ last four road games against NL West opponents have gone UNDER the total runs line.
- There has been no run scored during the first inning in seven of the last eight night games between the Cubs and Diamondbacks.
- There has been no run scored during the first inning in each of the Cubs’ last four games at Chase Field.
Arizona Diamondbacks Player Prop Facts
- Ildemaro Vargas has hit a home run in two of the Diamondbacks’ last three games as underdogs against NL opponents.
- Brandon Pfaadt has recorded a win in seven of his last nine appearances against NL opponents.
- Brandon Pfaadt has recorded five or more strikeouts in four of his last five appearances against the Cubs.
- Tim Tawa has recorded at least one hit in each of the Diamondbacks’ last nine night games against opponents that held a winning record.
- Gabriel Moreno ranks 7th amongst qualified players for Batting Average (.303) this season.
Chicago Cubs Player Prop Facts
- Pete Crow-Armstrong has hit at least one home run in seven of the Cubs’ last nine games as favorites against NL West opponents.
- Clay Holmes has recorded a win in six of his last seven appearances with his team as a road favorite against NL opponents.
- Clay Holmes has recorded four or more strikeouts in each of his last four road appearances against NL opponents.
- Seiya Suzuki has recorded at least one hit in each of the Cubs’ last nine games against NL West opponents.
- Pete Crow-Armstrong ranks 2nd amongst qualified players for Slugging Percentage (.554) this season.
Matchup/League Facts
- The Diamondbacks rank 1st in the league for triples this season (35).
- The Diamondbacks rank 2nd in the league for strikeouts against this season (957).
- The Cubs rank 1st in the league for on-base percentage this season (.339).
- The Cubs rank 1st in the league for walks this season (562).
Diamondbacks vs Cubs Prediction
The Cubs are the better team, and Holmes has been terrific with a 2.49 ERA and 1.11 WHIP. However, the Diamondbacks are fighting for a playoff spot, and they’ve won 9 of the last 10 games Pfaadt has pitched. This month, through 26.1 innings, Pfaadt has allowed 16 hits and 5 earned runs. Pfaadt has become the Diamondbacks ace and if theyre going to close the wild card gap they should win with him on them mound at home. Pick ’em price: give me the Diamondbacks with their star pitcher.