Diamondbacks vs Dodgers Prediction 9/25/25 MLB Picks Today

The Los Angeles Dodgers and Arizona Diamondbacks meet Thursday in MLB action at Chase Field. Here’s a Diamondbacks vs Dodgers Prediction. This article will include a Diamondbacks vs Dodgers Pick.

Los Angeles Dodgers Betting Preview

The Los Angeles Dodgers are 89-69 on the year and play the Mariners next. The Los Angeles Dodgers are batting .253 on the season, have a .328 OBP, and a .440 slugging percentage. The Los Angeles Dodgers pitching staff has a 4.02 ERA and a 1.26 WHIP. Shohei Ohtani leads the Los Angeles Dodgers with 168 hits and 99 RBI, while Freddie Freeman and Andy Pages have combined for 316 hits and 169 RBI.

Yoshinobu Yamamoto gets the ball for the Los Angeles Dodgers, and he is 11-8 with a 2.58 ERA and 194 strikeouts this season. Yamamoto is 2-1 with a 2.30 ERA and 36 strikeouts in his career against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 80-78 on the year and play the Padres next. The Arizona Diamondbacks are batting .252 on the season, have a .325 OBP, and a .434 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.42 ERA and a 1.31 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 168 hits and 98 RBI while Corbin Carroll and Ketel Marte have combined for 279 hits and 154 RBI.

Zac Gallen gets the ball for the Arizona Diamondbacks, and he is 13-14 with a 4.70 ERA and 172 strikeouts this season. Gallen is 2-5 with a 3.90 ERA and 99 strikeouts in his career against the Los Angeles Dodgers.

Los Angeles Dodgers @ Arizona Diamondbacks Betting Trends: September 25, 2025

• Probable Starting Pitcher: Zac Gallen      Record this season: 13-14      ERA: 4.70
• Home Record: 6-7
• Last 5 against Dodgers: 2-1

Why the Arizona Diamondbacks will win

• The Dodgers have lost seven of their last eight games as road favorites following a win.
• The Diamondbacks have won each of their last seven day games against NL West opponents following a home loss.
• The Diamondbacks have covered the run line in each of their last eight games as home underdogs.
• The Dodgers have failed to cover the run line in each of their last six games as favorites after going to extra innings.
• The Diamondbacks have led after 3 innings in each of their last four day games against opponents that held a winning record.
• The Diamondbacks have won the first inning in 11 of their last 14 home games against National League opponents that held a winning record.
• The Diamondbacks have led after 5 innings in seven of their last eight day games at Chase Field against National League opponents.

• Probable Starting Pitcher: Yoshinobu Yamamoto      Record this season: 11-8      ERA: 2.58
• Road Record: 8-4
• Last 5 against Diamondbacks: 2-1

Why the Los Angeles Dodgers will win

• The Dodgers have won each of their last nine day games against NL West opponents that held a winning record.
• The Diamondbacks have lost six of their last seven day games against National League opponents following a loss.
• The Dodgers have covered the run line in each of their last six Thursday day games against NL West opponents.
• The Diamondbacks have failed to cover the run line in eight of their last 10 games against National League opponents after going to extra innings.
• The Dodgers have won the first inning in six of their last eight day games.
• The Dodgers have led after 5 innings in each of their last seven games against opponents that held a winning record.
• The Dodgers have led after 3 innings in each of their last three day games against the Diamondbacks.

Total Runs Facts

• Seven of the Dodgers’ last eight road games after going to extra innings have gone OVER the total runs line.
• Nine of the Diamondbacks’ last 11 home games following an extra innings loss have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 17 of the Diamondbacks’ last 19 home games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Dodgers’ last eight day games.

Arizona Diamondbacks Player Prop Facts

• Geraldo Perdomo ranks 5th amongst qualified players for On Base Percentage (.391) this season.

Los Angeles Dodgers Player Prop Facts

• Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.617) this season.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (37).
• The Diamondbacks rank 3rd in the league for RBIs this season (757).
• The Dodgers rank 2nd in the league for runs scored this season (798).
• The Dodgers rank 2nd in the league for RBIs this season (765).

Diamondbacks vs Dodgers Prediction

The Dodgers are going to get the benefit of the doubt because they’re the Dodgers. Yamamoto has also been ridiculous lately, allowing 7 hits and 3 runs in his last 28 innings. In 99.2 road innings, Yamamoto has a 2.26 ERA and .167 allowed batting average. I get it. However, the Diamondbacks are fighting for their playoff lives and Gallen is a quality pitcher who is tough to turn down with plus money. It’s been a down year for Gallen, but he’s allowed 21 hits and 10 runs in his last 37.2 innings. Gallen looks like Gallen again, and it makes the Diamondbacks worth a look with the more favorable price. Give me the home dog.