Diamondbacks vs Giants Prediction 5/25/26 MLB Picks Today

In this article, we will formulate a Diamondbacks vs Giants Prediction for this MLB matchup on Monday, May 25^th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Preview

The San Francisco Giants have a 22-31 record this season and are sitting in the fourth place of the NL West. They have a 12-13 home record and are coming off a 8-5 home win against the White Sox. They will face the Rockies and the Brewers next.

The Giants have a .247 batting average this season, .295 OBP and .387 Slugging percentage. San Francisco’s pitching staff has a 4.22 ERA and 1.34 WHIP. Luis Arraez is the team’s best hitter with a .320 batting average. Casey Schmitt leads the team in RBI with 29, adding a team-high 11 home runs.

Landen Roupp (R) is the projected starting pitcher for the Giants, and he has a 5-4 record, 3.27 ERA and 1.15 WHIP.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 28-24 record this season and are sitting in the third place of the NL West. They have a 10-14 away record and are coming off a 9-1 home win against the Rockies. They will face the Mariners and the Dodgers next.

The Diamondbacks have a .248 batting average this season, .313 OBP and .404 Slugging percentage. Arizona’s pitching staff has a 4.08 ERA and 1.25 WHIP. Ildemaro Vargas is the team’s best hitter with a .307 batting average, also leading the team in RBI with 32. Ketel Marte adds a team-high 8 home runs.

Merrill Kelly (R) is the projected starting pitcher for the Diamondbacks, and he has a 4-3 record, 5.71 ERA and 1.51 WHIP.

Arizona Diamondbacks @ San Francisco Giants Betting Trends: May 25, 2026

• Probable Starting Pitcher: Landen Roupp      Record this season: 5-4      ERA: 3.27
• Home Record: 2-2
• Last 5 against Diamondbacks: 0-0

Why the San Francisco Giants will win

• The Diamondbacks have lost seven of their last eight road games against the Giants following a win.
• The favorites have won each of the Giants’ last six games.
• The favorites have covered the run line in each of the Giants’ last six games.
• The Diamondbacks have failed to cover the run line in five of their last six games at Oracle Park.
• The Diamondbacks have trailed after 5 innings in each of their last four games as road underdogs against National League opponents.
• The Giants have won the first inning in three of their last four games as favorites against NL West opponents.
• The Diamondbacks have trailed after 3 innings in each of their last six games as road underdogs against National League opponents.

• Probable Starting Pitcher: Merrill Kelly      Record this season: 4-3      ERA: 5.71
• Road Record: 2-2
• Last 5 against Giants: 3-0

Why the Arizona Diamondbacks will win

• The Diamondbacks have won seven of their last eight games.
• The Giants have lost each of their last five games against NL West opponents.
• The Diamondbacks have covered the run line in each of their last 10 games as road underdogs against NL West opponents following a win.
• The Giants have failed to cover the run line in each of their last five games against NL West opponents.
• The Diamondbacks have led after 5 innings in five of their last six day games.
• The Diamondbacks have won the first inning in each of their last three games at Oracle Park against opponents that held a losing record.
• The Diamondbacks have led after 3 innings in each of their last four games at Oracle Park against opponents that held a losing record.

Total Runs Facts

• Seven of the Giants’ last eight games have gone OVER the total runs line.
• Four of the Diamondbacks’ last five games as underdogs have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last nine Monday day games at Oracle Park.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Diamondbacks’ last seven Monday games at Oracle Park.

San Francisco Giants Player Prop Facts

• Casey Schmitt has hit a home run in six of his last seven home appearances after playing the previous day.
• Rafael Devers has recorded at least one hit in each of the Giants’ last 14 games as favorites.
• Luis Arraez ranks T2nd in the league in Hits (63) this season.

Arizona Diamondbacks Player Prop Facts

• Geraldo Perdomo has hit a home run in three of the Diamondbacks’ last seven games as road underdogs against NL West opponents.
• Merrill Kelly has recorded a win in five of his last six road appearances against opponents that held a losing record.
• Merrill Kelly has recorded five or more strikeouts in each of his last 10 Monday appearances.
• Corbin Carroll has recorded at least one hit in each of his last 17 appearances against NL West opponents that held a losing record.
• Corbin Carroll ranks 5th amongst qualified players for Slugging Percentage (.580) this season.

Matchup/League Facts

• The Giants rank 30th in the league for steals this season (12).
• The Giants rank 30th in the league for walks this season (113).
• The Diamondbacks rank 1st in the league for triples this season (17).
• The Diamondbacks rank 30th in the league for strikeouts this season (372).

Diamondbacks vs Giants Prediction

The Diamondbacks are 6-1 in their last 7 meetings against the Giants but are 1-2 in their last 3 visits in San Francisco. They swept their previous series at home by 3-0 wins and a combined 23-8 score.

In this Diamondbacks vs Giants Prediction, the Giants are coming as -140 home favorites. The Giants are coming off back-to-back wins where they scored a combined 18 runs and their offense is starting to get hot. They also have the pitching edge in this game as Landen Roupp goes up against a struggling Merrill Kelly for the Dbacks and the Giants have superior bullpen, ranking 7^th in the league. I also like the fact that the Giants got swept in their previous series against the Dbacks, so this is a nice revenge spot. Take the Giants on the moneyline in this one.