Diamondbacks vs Phillies Prediction 9/19/25 MLB Picks Today

The Philadelphia Phillies and Arizona Diamondbacks meet Friday in MLB action at Chase Field. Here’s a Diamondbacks vs Phillies Prediction. This article will include a Diamondbacks vs Phillies Pick.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 91-62 on the year and play the Marlins and Twins next. The Philadelphia Phillies are batting .259 on the season, have a .330 OBP, and a .431 slugging percentage. The Philadelphia Phillies pitching staff has a 3.86 ERA and a 1.24 WHIP. Trea Turner leads the Philadelphia Phillies with 179 hits and 69 RBI, while Kyle Schwarber and Nick Castellanos have combined for 270 hits and 194 RBI.

Taijuan Walker gets the ball for the Philadelphia Phillies, and he is 5-8 with a 4.17 ERA and 79 strikeouts this season. This will be Walker’s second career game against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 77-76 on the year and play the Dodgers and Padres next. The Arizona Diamondbacks are batting .251 on the season, have a .324 OBP, and a .434 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.44 ERA and a 1.31 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 162 hits and 97 RBI while Corbin Carroll and Lourdes Gurriel Jr. have combined for 263 hits and 158 RBI.

Ryne Nelson gets the ball for the Arizona Diamondbacks, and he is 7-3 with a 3.34 ERA and 122 strikeouts this season. Nelson is 0-1 with a 4.15 ERA and 18 strikeouts in his career against the Philadelphia Phillies.

Philadelphia Phillies @ Arizona Diamondbacks Betting Trends: September 19, 2025

• Probable Starting Pitcher: Ryne Nelson      Record this season: 7-3      ERA: 3.34
• Home Record: 5-1
• Last 5 against Phillies: 0-1

Why the Arizona Diamondbacks will win

• The Phillies have lost each of their last nine games as underdogs against NL West opponents following a road loss.
• The Diamondbacks have won each of their last five games after going to extra innings.
• The Phillies have failed to cover the run line in eight of their last nine games as underdogs against NL West opponents following a road loss.
• The Diamondbacks have covered the run line each of their last six Friday games against NL East opponents that held a winning record.
• The Phillies have trailed after 5 innings in each of their last nine games as road underdogs against NL West opponents.
• The Phillies have trailed after 3 innings in 10 of their last 12 games as road underdogs.
• The Diamondbacks have won the first inning in each of their last nine home games against National League opponents that held a winning record.

• Probable Starting Pitcher: Taijuan Walker      Record this season: 5-8      ERA: 4.17
• Road Record: 2-4
• Last 5 against Diamondbacks: 0-1

Why the Philadelphia Phillies will win

• The Phillies have won each of their last four games as underdogs following a loss.
• The Diamondbacks have lost five of their last six games as favorites against NL East opponents.
• The Phillies have covered the run line in 11 of their last 12 games as underdogs following a loss.
• The Diamondbacks have failed to cover the run line in seven of their last eight games as favorites against National League opponents.
• The Diamondbacks have trailed after 3 innings in five of their last six night games against NL East opponents that held a winning record.
• The Phillies have won the first inning in three of their last four games against the Diamondbacks.

Total Runs Facts

• Eight of the Phillies’ last nine games have gone OVER the total runs line.
• Each of the Diamondbacks’ last four games against NL East opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 13 of the Diamondbacks’ last 14 home games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Phillies’ last eight night games against NL West opponents.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has hit at least one home run in six of the Diamondbacks’ last eight home games against NL East opponents that held a winning record.
• Lourdes Gurriel Jr. has recorded a Double in four of the Diamondbacks’ last five night games against NL East opponents that held a winning record.
• Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last 18 games as favorites.
• Geraldo Perdomo ranks 5th amongst qualified players for On Base Percentage (.391) this season.

Philadelphia Phillies Player Prop Facts

• J.T. Realmuto has hit a home run in each of his last two appearances with the Phillies as underdogs against the Diamondbacks.
• Alec Bohm has recorded a Double in three of the Phillies’ last four road games against the Diamondbacks.
• Trea Turner has recorded at least one hit in each of his last 15 road appearances.
• Kyle Schwarber ranks 2nd in the league in Home Runs (53) this season.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (37).
• The Diamondbacks rank 3rd in the league for RBIs this season (737).
• The Phillies rank 2nd in the league for walks allowed this season (415).
• The Phillies rank 3rd in the league for hits this season (1350).

Diamondbacks vs Phillies Prediction

The Phillies are the better team, but Walker has been hittable all season, and he’s allowed 22 hits and 13 runs in his last 15 innings. Walker has allowed 17 runs in his last 20 innings. Nelson has allowed 17 hits and 5 runs in his last 24 innings. In 75.1 home innings, Nelson has a 2.51 ERA and .200 allowed batting average. The Diamondbacks are also fighting for their wild card lives, while the Phillies are in a comfortable spot in the NL. Pretty close to a must win game for the Diamondbacks. I’ll lay the reasonable price.