Diamondbacks vs Rays Prediction 4/22/25 MLB Picks Today

In this article we will formulate a Diamondbacks vs Rays prediction for this MLB game on Tuesday, April 22nd at Chase Field in Phoenix, Arizona. Let’s take a look at the prediction for this MLB matchup. 

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 13-9 this year after they lost two out of three against the Cubs by scores of 11-13, 2-6, and 3-2. In their game three win, the Diamondbacks tied the game at one in the fourth inning, but didn’t score again until the 10th, and ended up winning in the 11th. The Diamondbacks recorded eight hits and they recorded two errors in the game, while they were led by Naylor, who went 3-5 with two RBIs in the win. Arizona started Kelly, who allowed two hits and one earned run over 5.2 innings, while Miller got the win and Jameson got the save. 

Prior to that series, the Diamondbacks swept the Marlins in three games and won two out of three against the Brewers. Arizona has won six of their last eight games and they are currently fourth in the NL West standings. The Arizona pitching staff has a 4.43 ERA with a 1.22 WHIP and a .234 opponent batting average, while their offense has scored 120 runs with a .251 batting average and a .340 on base percentage this year. Corbin Carroll has led Arizona with seven home runs and 19 RBIs, while Geraldo Perdomo has added three home runs and 19 RBIs this season. The projected starting pitcher for Arizona is Brandon Pfaadt, who is 3-1 with a 3.04 ERA and a 1.10 WHIP over 23.2 innings pitched this year. 

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 9-13 this season after they lost three out of four against the Yankees by scores of 3-6, 0-1, 10-8, and 0-4. In their game four loss, Tampa Bay fell behind in the first inning and couldn’t find any offense in the game to get back into it. The Rays recorded just two hits in the game and they were led by Mangum and Simpson, who both had one hit in the loss. TB started Pepiot, who allowed six hits and three earned runs over 6.0 innings in the loss, while Cleavinger allowed one hit and one earned run in one inning of relief work. 

Prior to that series, the Rays lost two out of three against the Red Sox, but did win two out of three against the Braves before that. Tampa Bay has lost five of their last six games and they are last in the AL East standings. The Tampa Bay pitching staff has a 3.66 ERA with a 1.17 WHIP and a .234 opponent batting average, while the offense has scored 94 runs with a .258 batting average and a .326 on base percentage this season. Junior Caminero has led Tampa Bay with five home runs and 11 RBIs, while Jonathan Aranda has added four home runs and 13 RBIs for the Rays this year. The projected starting pitcher for Tampa Bay is Zack Littell, who is 0-4 with a 5.48 ERA and a 1.26 WHIP over 23.0 innings pitched this year. 

Why the Diamondbacks will beat the Rays

• The Rays have lost eight of their last nine road games against teams that held a winning record.
• The Diamondbacks have won 10 of their last 11 games against American League opponents following a road win.
• The Diamondbacks have covered the run line in eight of their last nine games against American League opponents following a win.
• The Rays have failed to cover the run line each of their last six Tuesday night games against NL West opponents that held a winning record.
• The Rays have trailed after 3 innings in seven of their last eight games as underdogs.
• The Rays have lost the first inning in four of their last five games against opponents that held a winning record.
• The Diamondbacks have led after 5 innings in five of their last six night games against American League opponents that held a losing record.

Total Runs Facts

• Seven of the Rays’ last eight night games against NL West opponents have gone OVER the total runs line.
• Seven of the Diamondbacks’ last eight games after going to extra innings have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Diamondbacks’ last eight games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 13 of the Rays’ last 15 night games against National League opponents.

Arizona Diamondbacks Player Prop Facts

• Josh Naylor has hit a home run in three of the Diamondbacks’ last four games as favorites.
• Josh Naylor has recorded a Double in four of the Diamondbacks’ last five home games against opponents that held a losing record.
• Brandon Pfaadt has recorded a win in four of his last five appearances.
• Corbin Carroll has recorded at least one RBI in each of the Diamondbacks’ last four games as favorites.
• Pavin Smith has scored at least one run in each of his last six appearances against AL East opponents.
• Geraldo Perdomo has recorded at least one Single in each of the Diamondbacks’ last six games as favorites against AL opponents.
• Brandon Pfaadt has recorded six or more strikeouts in five of his last six appearances with the Diamondbacks as favorites against AL opponents.
• Josh Naylor has recorded at least one hit in each of his last 11 home appearances against opponents that held a losing record.
• Brandon Pfaadt ranks T2nd in the league for Wins (3) this season.

Tampa Bay Rays Player Prop Facts

• Brandon Lowe has hit a home run in each of the Rays’ last two games against the Diamondbacks.
• Brandon Lowe has recorded at least one Double in three of the Rays’ last four road games against NL West opponents.
• Danny Jansen has scored a run in seven of his last eight appearances with his team as an underdog against NL West opponents.
• Yandy Diaz has recorded at least one Single in each of his last seven appearances against NL opponents that held a winning record.
• Brandon Lowe has recorded at least one hit in each of his last 13 appearances against NL West opponents.
• Josh Lowe has recorded at least one RBI in four of the Rays’ last five games against the Diamondbacks.
• Jake Mangum ranks T2nd in the league in Steals (8) this season.

Matchup/League Facts

• The Diamondbacks rank T3rd in the league for runs scored this season (120).
• The Diamondbacks rank 3rd in the league for RBIs this season (117).
• The Rays rank 30th in the league for home runs allowed this season (34).
• The Rays are one of only three teams in the league to rank top 10 in both strikeouts and on-base percentage this season.

Diamondbacks vs Rays Prediction 

Arizona comes into this series with a 13-9 record on the season, but they are just fourth in the highly competitive NL West. The Diamondbacks are 6-4 at home this year, while the Rays are 0-3 on the road. Tampa Bay has really struggled over the last week and they have been shutout in three of their last five games. Arizona’s pitching staff has been below average to start the season, but Pfaadt has had two very good starts in a row. Tampa Bay is going with Littell, who has allowed at least five runs in two of his last three starts. Take Arizona -1.5 here.