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Diamondbacks vs Rockies Prediction 9/22/26 MLB Picks Today

Arizona Diamondbacks (82-74) vs. Colorado Rockies (57-99)
September 22, 2026 8:40 pm EDT
The Line: Colorado Rockies 162 / Arizona Diamondbacks -198; Over/Under: 11
(Get latest betting odds)

In this article, we will formulate a Diamondbacks vs Rockies Prediction for this MLB matchup on Tuesday, September 22nd in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Colorado Rockies Preview

The Colorado Rockies have a 57-99 record this season and are sitting in the 5th place of the NL West. They have a 32-46 home record and are coming off a 2-1 home loss against the Mariners. They will face the White Sox next.

The Colorado Rockies have a .254 batting average this season, .323 OBP and .416 Slugging percentage. Colorado’s pitching staff has a 5.57 ERA and 1.53 WHIP. TJ Rumfield is the team’s best hitter with a .300 batting average. Jake McCarthy leads the team in RBI with 83, while Hunter Goodman adds a team-high 39 home runs.

Kyle Freeland (L) is the projected starting pitcher for the Rockies, and he has a 4-10 record, 6.38 ERA and 1.47 WHIP.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 82-74 record this season and are sitting in the 3rd place of the NL West. They have a 37-38 away record and are coming off an 8-4 home win against the Yankees. They will face the Padres next.

The Arizona Diamondbacks have a .244 batting average this season, .316 OBP and .398 Slugging percentage. Arizona’s pitching staff has a 4.11 ERA and 1.28 WHIP. Gabriel Moreno is the team’s best hitter with a .307 batting average. Nolan Arenado leads the team in RBI with 78, adding a team-high 27 home runs.

Michael Soroka (R) is the projected starting pitcher for the Diamondbacks, and he has an 8-5 record, 3.45 ERA and 1.13 WHIP.

Arizona Diamondbacks @ Colorado Rockies Betting Trends: September 22, 2026

 

  • Probable Starting Pitcher: Kyle Freeland      Record this season: 4-10      ERA: 6.38
  • Home Record: 3-3
  • Last 5 against Diamondbacks: 1-3

Why the Colorado Rockies will win

  • The Diamondbacks have lost each of their last seven night games following a home win.
  • The underdogs have won four of the Diamondbacks’ last five games.
  • The Rockies have covered the run line in each of their last eight night games at Coors Field following a loss.
  • The Diamondbacks have failed to cover the run line in each of their last seven night games following a home win.
  • The Diamondbacks have trailed after 3 innings in each of their last three games as favorites.
  • The Diamondbacks have trailed after 5 innings in five of their last six night games against NL opponents.

 

  • Probable Starting Pitcher: Michael Soroka      Record this season: 8-5      ERA: 3.45
  • Road Record: 4-2
  • Last 5 against Rockies: 1-2

Why the Arizona Diamondbacks will win

  • The Rockies have lost 12 of their last 13 games against teams that held a winning record.
  • The Diamondbacks have won four of their last five road games.
  • The road team has covered the run line in six of the Diamondbacks’ last eight games.
  • The Rockies have failed to cover the run line in six of their last eight night games against teams that held a winning record.
  • The Diamondbacks have won the first inning in each of their last four games against the Rockies.
  • The Diamondbacks have led after 3 innings in each of their last four night games against the Rockies.
  • The Rockies have trailed after 5 innings in each of their last 12 night games against opponents that held a winning record.

Total Runs Facts

  • Each of the Rockies’ last seven night games against NL opponents have gone OVER the total runs line.
  • Each of the Diamondbacks’ last six road games have gone UNDER the total runs line.
  • There has been at least one run scored in the first inning in each of the Diamondbacks’ last six night games at Coors Field.
  • There has been at least one run scored in the first inning in nine of the last 10 night games between the Diamondbacks and Rockies at Coors Field.

Colorado Rockies Player Prop Facts

  • Mickey Moniak has hit at least one home run in 10 of his last 16 home appearances against opponents that held a winning record.
  • Kyle Freeland has recorded four or more strikeouts in six of his last seven home appearances.
  • TJ Rumfield has recorded at least one hit in each of his last 13 home appearances against NL West opponents.
  • TJ Rumfield ranks 3rd amongst qualified players for On Base Percentage (.392) this season.

Arizona Diamondbacks Player Prop Facts

  • Gabriel Moreno has hit a home run in three of the Diamondbacks’ last four games against opponents that held a losing record.
  • Michael Soroka has recorded a win in each of his last four appearances with his team as a road favorite against NL West opponents.
  • Michael Soroka has recorded seven or more strikeouts in three of his last four appearances with his team as a road favorite against NL West opponents.
  • Ketel Marte has recorded two or more hits in seven of his last eight appearances against the Rockies.
  • Gabriel Moreno ranks 4th amongst qualified players for Batting Average (.307) this season.

Matchup/League Facts

  • The Rockies rank 1st in the league for triples this season (39).
  • The Rockies rank 30th in the league for ERA this season (5.57).
  • The Diamondbacks rank 2nd in the league for triples this season (38).
  • The Diamondbacks rank 29th in the league for strikeouts this season (1094).

Diamondbacks vs Rockies Prediction

The Diamondbacks are 5-3 in their last 8 meetings against the Rockies and have won two of their last three visits in Colorado.

In this Diamondbacks vs Rockies Prediction, the Diamondbacks are coming as -185 road favorites. The Dbacks are still clinging into their wild card hopes and have won back-to-back games against the Yankees. They will face a struggling Rockies team that is just 2-8 in its last 10 games and are putting Kyle Freeland on the mound, who has given up 7 runs in his last two starts and has a 6.38 ERA and 1.47 WHIP this season. Soroka has been solid this season and the Dbacks are better against lefties, with their bullpen being in excellent form lately. Take the Dbacks to win this one on the road.

Nikos Lagouretos's Free Pick: Arizona Diamondbacks ML

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