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Dodgers vs Cardinals Prediction 8-6-25 MLB Picks Today

St. Louis Cardinals (57-58) vs. LA Dodgers (66-48)
August 6, 2025 4:10 pm EDT
The Line: LA Dodgers -219 / St. Louis Cardinals 177; Over/Under: 9
(Get latest betting odds)

In this article, we will formulate a Dodgers vs Cardinals prediction for this MLB game on Wednesday, August 6, at Dodger Stadium in Los Angeles, California. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals (57-58, 25-34 Away) are still without a series win in the second half of the season. The previous two losses came to the Miami Marlins and the San Diego Padres. The Cards did open the current series against the Dodgers with a win, but then lost Game 2 on Tuesday, 12-6. Nolan Gorman led the offense with two RBI, while Miles Mikolas took the loss after allowing five runs on seven hits with one strikeout and one walk in 3.0 innings.

This year, the Cardinals average 4.38 runs per game (14th in the MLB) on a .249/.319/.388 triple-slash. When it comes to pitching, the Cardinals’ staff has a 4.19 ERA (20th) and 1.28 WHIP (18th). Willson Contreras leads the Cardinals with a .258 batting average, 16 home runs, and 64 RBI this season.

The projected starting pitcher for the Cardinals is Matthew Liberatore, who is 6-9 in 20 starts this season, with a 3.96 ERA and 1.28 WHIP in 109.0 innings.

Los Angeles Dodgers Betting Preview

The Los Angeles Dodgers (66-48, 36-22 Home) lost against the Boston Red Sox and defeated the Cincinnati Reds and Tampa Bay Rays in the last three series, all three on the road. The Dodgers fell short in the opening game of this series against the Cardinals, but won 12-6 last night. Mookie Betts and Teoscar Hernandez led the offense with four RBI apiece, while Emmet Sheehan got the win after allowing two runs (none earned) on four hits with five strikeouts and one walk in 5.0 innings.

This season, the Dodgers average 5.14 runs per game (3rd in the MLB) on a .254/.329/.439 triple-slash. When it comes to pitching, the Dodgers’ staff has a 4.17 ERA (19th) and 1.30 WHIP (22nd). Shohei Ohtani leads the Dodgers with a .276 batting average, 38 home runs, and 73 RBI this season.

Shohei Ohtani will take the mound for the Dodgers on Wednesday. The 31-year-old right-hander has a 0-0 record in seven starts this year with a 2.40 ERA and 1.27 WHIP in 15.0 innings.

Total Runs Facts

  • Eight of the Dodgers’ last nine day games as favorites have gone UNDER the total runs line.
  • Six of the Cardinals’ last eight day games after playing the previous day have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the Dodgers’ last 11 day games against National League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cardinals’ last eight games against National League opponents.

Matchup/League Facts

  • The Dodgers rank 2nd in the league for home runs this season (169).
  • The Dodgers rank 2nd in the league for slugging percentage this season (.441).
  • The Cardinals rank 3rd in the league for walks allowed this season (302).
  • The Cardinals rank T5th in the league for doubles this season (198).

Dodgers vs Cardinals Prediction

The teams have traded wins in the past few years, each recording five in the previous ten H2H meetings. This season, the Cardinals lead 3-2. Three of those five duels went Under, and given the pitching matchup in this one, I am going with another Under. Shohei Ohtani will probably stay on the mound for 3.0 innings and will most likely not allow more than a run. Matthew Liberatore, on the other hand, wasn’t impressive recently, but I don’t think the Dodgers will score more than three or four against him. Go with Under.

Oliver Zivic's Free Pick: Under 9.5

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Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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