Dodgers vs Diamondbacks Prediction 5/21/25 MLB Picks Today

Chris Ruffolo

Arizona Diamondbacks (26-23) vs. LA Dodgers (30-19)
May 21, 2025 10:10 pm EDT
The Line: LA Dodgers -135 / Arizona Diamondbacks +114; Over/Under: 9
(Get latest betting odds)

The Arizona Diamondbacks and the Los Angeles Dodgers meet Wednesday in MLB action from Dodger Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Dodgers vs Diamondbacks Prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Corbin Burnes for the start here, and Burnes is 3-1 with a 2.56 ERA and 43 strikeouts this season. In his last five starts against the Dodgers, Burnes is 2-2 with a 2.54 ERA and 27 strikeouts. Dustin May will get the start against the Diamondbacks here and is 1-4 with a 4.43 ERA and 41 strikeouts this season. In his last five starts against Arizona, May is 1-2 with a 2.92 ERA and 18 strikeouts.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to bounce back from their 4-3 loss at the hands of the Dodgers in Tuesday’s matchup to fall to 26-23 on the year. After this series, the Diamondbacks will head on the road for a series against the St. Louis Cardinals.

Diamondbacks Looking To Win Rubber Match

Corbin Carroll has a team-high 57 hits with 15 home runs, 34 RBIs, 6 triples, and 9 doubles, while Josh Naylor has 53 hits with 12 doubles, 5 home runs, and 29 RBIs as well this season. Eugenio Suarez has also added 14 home runs and 38 RBIs, while Geraldo Perdomo has 37 RBIs. Naylor has also chipped in 8 stolen bases as well up to this point in the year, while Carroll has the unfortunate distinction of leading the Diamondbacks with 57 strikeouts so far this season. Carroll also has 9 stolen bases, and Perdomo has a team-high 11 stolen bases as well this season.

Why the Arizona Diamondbacks will win

The Diamondbacks have won seven of their last eight games as road underdogs against NL West opponents following a loss.
The Dodgers have lost five of their last six games as favorites following a win.
The Diamondbacks have covered the run line in each of their last nine games as road underdogs against NL West opponents.
The Dodgers have failed to cover the run line in each of their last five games.

Arizona Diamondbacks Player Prop Facts

Gabriel Moreno has hit a home run in four of his last five appearances with the Diamondbacks as underdogs against the Dodgers.
Geraldo Perdomo has recorded a Double in three of the Diamondbacks’ last four games as underdogs against NL West opponents.
Gabriel Moreno has recorded at least one RBI in each of his last five appearances with the Diamondbacks as underdogs against the Dodgers.
Corbin Burnes has recorded a win in each of his last three appearances.
Corbin Burnes has recorded seven or more strikeouts in four of his last five appearances with his team as an underdog.
Ketel Marte has recorded at least one Single in each of his last 11 appearances with the Diamondbacks as road underdogs against NL West opponents.
Corbin Carroll has scored at least one run in each of the Diamondbacks’ last 10 road games against NL West opponents that held a winning record.
Lourdes Gurriel Jr. has recorded at least one hit in each of his last 16 road appearances against NL West opponents that held a winning record.
Corbin Carroll ranks T4th in the league in Home Runs (15) this season.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to build on their win over the Diamondbacks on Tuesday to improve to 30-19 on the year. After this series, the Dodgers will head on the road for a series against the New York Mets.

Dodgers Snap Four-Game Losing Streak

Shohei Ohtani has 59 hits, including 9 doubles, 17 home runs, 31 RBIs, and 4 triples, while Tommy Edman has 30 hits with 8 home runs and 26 RBIs. Michael Conforto has 24 hits with 9 doubles, while Teoscar Hernandez has 41 hits with 9 home runs, 10 doubles, and 34 RBIs as well this season. Ohtani has a team-high 11 stolen bases, while Max Muncy has 8 doubles but also has 47 strikeouts so far this season. Mookie Betts has also chipped in 8 home runs and 30 RBIs on the year.

Why the Los Angeles Dodgers will win

The Dodgers have won each of their last 11 games at Dodger Stadium after going to extra innings.
The Diamondbacks have lost seven of their last eight games at Dodger Stadium after going to extra innings.
The Dodgers have covered the run line in each of their last nine home games after going to extra innings.
The Diamondbacks have failed to cover the run line in each of their last four night games at Dodger Stadium after going to extra innings.

Los Angeles Dodgers Player Prop Facts

Freddie Freeman has recorded at least one Double in four of the Dodgers’ last five games against NL West opponents at Dodger Stadium.
Tommy Edman has recorded at least one RBI in each of his last five appearances against the Diamondbacks.
Shohei Ohtani has hit a home run in each of the Dodgers’ last five Wednesday night games as favorites.
Andy Pages has recorded at least one Single in each of his last six appearances against the Diamondbacks after playing the previous day.
Dustin May has recorded five or more strikeouts in each of his last four appearances against NL opponents that held a winning record.
Shohei Ohtani has scored at least one run in each of the Dodgers’ last seven games as favorites against the Diamondbacks.
Freddie Freeman has recorded at least one hit in each of the Dodgers’ last 19 games as favorites against NL opponents.
Shohei Ohtani ranks T1st in the league in Home Runs (17) this season.

Total Runs Facts

Each of the Diamondbacks’ last 12 games following an extra innings loss have gone OVER the total runs line.
Each of the Dodgers’ last four games after going to extra innings have gone OVER the total runs line.