San Francisco Giants (76-79) vs. LA Dodgers (88-67)
September 21, 2025 4:10 pm EDT
The Line: LA Dodgers -232 / San Francisco Giants 186; Over/Under: 9
(Get latest betting odds)
The San Francisco Giants and Los Angeles Dodgers meet Sunday in MLB action at Dodger Stadium. Here’s a Dodgers vs Giants Prediction. This article will include a Dodgers vs Giants Pick.
San Francisco Giants Betting Preview
The San Francisco Giants are 76-79 on the year and play the Cardinals and Rockies next. The San Francisco Giants are batting .235 on the season, have a .311 OBP, and a .385 slugging percentage. The San Francisco Giants pitching staff has a 3.87 ERA and a 1.30 WHIP. Heliot Ramos leads the San Francisco Giants with 152 hits and 62 RBI, while Jung Hoo Lee and Willy Adames have combined for 269 hits and 134 RBI.
Trevor McDonald gets the ball for the San Francisco Giants, and he is 0-0 with a 9.00 ERA and 1 strikeout this season. This will be McDonald’s first career game against the Los Angeles Dodgers.
Los Angeles Dodgers Betting Preview
The Los Angeles Dodgers are 88-67 on the year and play the Diamondbacks and Mariners next. The Los Angeles Dodgers are batting .254 on the season, have a .330 OBP, and a .441 slugging percentage. The Los Angeles Dodgers pitching staff has a 4.03 ERA and a 1.27 WHIP. Shohei Ohtani leads the Los Angeles Dodgers with 166 hits and 99 RBI while Freddie Freeman and Andy Pages have combined for 311 hits and 167 RBI.
Emmet Sheehan gets the ball for the Los Angeles Dodgers, and he is 6-3 with a 3.17 ERA and 76 strikeouts this season. Sheehan is 1-0 with a 1.20 ERA and 15 strikeouts in his career against the San Francisco Giants.
San Francisco Giants @ Los Angeles Dodgers Betting Trends: September 21, 2025
- Probable Starting Pitcher: Emmet Sheehan Record this season: 6-3 ERA: 3.17
- Home Record: 3-1
- Last 5 against Giants: 1-0
Why the Los Angeles Dodgers will win
- The Dodgers have won each of their last 14 day games against NL West opponents.
- The Giants have lost eight of their last nine games after playing the previous day.
- The Dodgers have covered the run line each of their last six games against teams that held a losing record.
- The Giants have failed to cover the run line in four of their last five day games against NL West opponents that held a winning record.
- The Dodgers have won the first inning in six of their last seven day games.
- The Dodgers have led after 5 innings in eight of their last nine day games against National League opponents.
- The Dodgers have led after 3 innings in seven of their last eight day games.
- Probable Starting Pitcher: Trevor McDonald Record this season: 0-0 ERA: 9.00
- Road Record: 0-0
- Last 5 against Dodgers: –
Why the San Francisco Giants will win
- The Dodgers have failed to cover the run line in each of their last five day games at Dodger Stadium following a win.
- The Giants have covered the run line in 13 of their last 14 Sunday games as road underdogs.
- The Dodgers have trailed after 3 innings in six of their last eight games against National League opponents that held a losing record.
Total Runs Facts
- Six of the Giants’ last seven day games against National League opponents have gone UNDER the total runs line.
- Three of the Dodgers’ last four day games against NL West opponents have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Dodgers’ last seven day games.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Giants’ last six games at Dodger Stadium.
Los Angeles Dodgers Player Prop Facts
- Shohei Ohtani has hit a home run in four of the Dodgers’ last five games.
- Mookie Betts has recorded a Double in three of the Dodgers’ last four games against opponents that held a losing record.
- Mookie Betts has recorded at least one hit in each of his last 12 appearances against NL West opponents that held a losing record.
- Shohei Ohtani ranks T2nd in the league in Home Runs (53) this season.
San Francisco Giants Player Prop Facts
- Rafael Devers has hit a home run in four of the Giants’ last 10 road games against NL West opponents.
- Dominic Smith has recorded a Double in three of his last four road appearances against the Dodgers.
- Dominic Smith has recorded at least one hit in 17 of his last 19 road appearances.
Matchup/League Facts
- The Dodgers rank 2nd in the league for runs scored this season (793).
- The Dodgers rank 2nd in the league for home runs this season (232).
- The Giants rank 1st in the league for home runs allowed this season (136).
- The Giants rank 29th in the league for steals this season (66).
Dodgers vs Giants Prediction
The Giants are watching their season fall apart, with losses in 7 of their last 8 games. It’s hard to take the Giants seriously in their current form. McDonald also has just 5 career MLB innings under his belt, so the small sample size makes him hard to back. The Dodgers are heating up and Sheehan has allowed 11 hits and 4 runs in his last 24.1 innings. In 36.2 home innings, Sheehan has a 2.21 ERA and .191 allowed batting average. The Dodgers put their hated rival out of their misery. Of course, I’ll lay the RL to shave down the juice.
