Giants vs Cardinals Prediction 9/7/26 MLB Picks Today
St. Louis Cardinals (72-72) vs. San Francisco Giants (59-85)
September 7, 2026 8:10 pm EDT
The Line: San Francisco Giants -131 / St. Louis Cardinals 109; Over/Under: 7.5
(Get latest betting odds)
The St. Louis Cardinals and San Francisco Giants meet Monday in MLB action at Oracle Park. Here’s a Giants vs Cardinals Prediction. This article will include a Giants vs Cardinals Pick.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 72-72 on the year and play the White Sox and Giants next. The St. Louis Cardinals are batting .244 on the season, with a .317 OBP and a .387 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.32 ERA and a 1.35 WHIP. Jordan Walker leads the St. Louis Cardinals with 156 hits and 100 RBI, while Alec Burleson and Ivan Herrera have combined for 291 hits and 167 RBI.
Michael McGreevy gets the ball for the St. Louis Cardinals, and he is 6-9 with a 3.97 ERA and 102 strikeouts this season. McGreevy is 2-1 with a 6.35 ERA and 11 strikeouts in his career against the San Francisco Giants.
San Francisco Giants Betting Preview
The San Francisco Giants are 59-85 on the year and play the Padres and Cardinals next. The San Francisco Giants are batting .248 on the season, have a .308 OBP, and have a .407 slugging percentage. The San Francisco Giants’ pitching staff has a 4.39 ERA and a 1.36 WHIP. Rafael Devers leads the San Francisco Giants with 140 hits and 91 RBI, while Jung Hoo Lee and Willy Adames have combined for 246 hits and 104 RBI.
Logan Webb gets the ball for the San Francisco Giants, and he is 8-8 with a 4.21 ERA and 119 strikeouts this season. Webb is 3-3 with a 5.19 ERA and 38 strikeouts in his career against the St. Louis Cardinals.
Why the San Francisco Giants will win
- The Giants have won nine of their last 10 home games following a road loss.
- The Cardinals have lost five of their last six road games following a win.
- The Giants have covered the run line in each of their last six home games against NL opponents following a road loss.
- The Cardinals have failed to cover the run line in each of their last five night games against NL West opponents that held a losing record.
- The Giants have won the first inning in four of their last five night games at Oracle Park.
- The Giants have led after 3 innings in three of their last four home games against NL Central opponents.
- The Giants have led after 5 innings in seven of their last eight games as favorites.
Why the St. Louis Cardinals will win
- The Cardinals have won each of their last four games as underdogs against the Giants.
- The Giants have lost seven of their last eight Monday games as home favorites.
- The Cardinals have covered the run line in each of their last nine games as underdogs against the Giants.
- The Giants have failed to cover the run line in eight of their last nine games as favorites against the Cardinals following a loss.
- The Cardinals have led after 3 innings in five of their last six night games.
- The Cardinals have led after 5 innings in eight of their last nine road games against opponents that held a losing record.
Total Runs Facts
- Ten of the Cardinals’ last 11 road games have gone OVER the total runs line.
- Five of the Giants’ last six night games against NL opponents have gone OVER the total runs line.
- There has been at least one run scored in the first inning in each of the Giants’ last 10 night games.
- There has been at least one run scored in the first inning in five of the Cardinals’ last six games as road underdogs.
San Francisco Giants Player Prop Facts
- Rafael Devers has hit a home run in each of the Giants’ last four night games.
- Logan Webb has recorded six or more strikeouts in 15 of his last 18 appearances with the Giants as favorites against NL Central opponents.
- Rafael Devers has recorded at least one hit in each of the Giants’ last 10 home games.
- Logan Webb has recorded a win in four of his last five home appearances against NL opponents.
- Rafael Devers ranks 8th in the league in Home Runs (35) this season.
St. Louis Cardinals Player Prop Facts
- Ivan Herrera has hit a home run in three of the Cardinals’ last four night games against NL West opponents that held a losing record.
- Ivan Herrera has recorded at least one hit in each of the Cardinals’ last 13 games against NL West opponents that held a losing record.
- Jordan Walker ranks T6th in the league in Hits (156) this season.
Matchup/League Facts
- The Giants rank 30th in the league for walks this season (397).
- The Giants rank 1st in the league for home runs allowed this season (138).
- The Cardinals rank 26th in the league for opponent batting average this season (.254).
- The Cardinals rank T5th in the league for home runs allowed this season (144).
Giants vs Cardinals Prediction
The Giants aren’t a team I want to make a habit of backing, but Webb has had a strong career when pitching at Oracle. In 103 games at Oracle, Webb has a 2.92 ERA and 1.11 WHIP with 586 strikeouts. McGreevy has allowed 35 hits and 19 earned runs in his last 31.1 innings. If forced to pick a side, I’m going to roll with the Giants because of the starting pitcher edge. Webb thrives pitching in San Francisco.