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Giants vs Cardinals Prediction 9/9/26 MLB Picks Today

St. Louis Cardinals (72-74) vs. San Francisco Giants (61-85)
September 9, 2026 3:45 pm EDT
The Line: San Francisco Giants 104 / St. Louis Cardinals -126; Over/Under: 8
(Get latest betting odds)

The St. Louis Cardinals and San Francisco Giants meet Wednesday in MLB action at Oracle Park. Here’s a Giants vs Cardinals Prediction. This article will include a Giants vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 72-74 this year and play the White Sox and Giants next. The St. Louis Cardinals are batting .243 on the season, with a .317 OBP and a .385 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.29 ERA and a 1.35 WHIP. Jordan Walker leads the St. Louis Cardinals with 157 hits and 100 RBI, while Alec Burleson and Ivan Herrera have combined for 293 hits and 168 RBI.


Andre Pallante gets the ball for the St. Louis Cardinals, and he is 12-6 with a 3.51 ERA and 98 strikeouts this season. Pallante is 1-0 with a 5.16 ERA and 17 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 61-85 on the year and play the Padres and Cardinals next. The San Francisco Giants are batting .247 on the season, have a .309 OBP, and have a .407 slugging percentage. The San Francisco Giants’ pitching staff has a 4.35 ERA and a 1.36 WHIP. Rafael Devers leads the San Francisco Giants with 142 hits and 92 RBI, while Jung Hoo Lee and Willy Adames have combined for 247 hits and 104 RBI.

Blade Tidwell gets the ball for the San Francisco Giants, and he is 0-2 with a 4.43 ERA and 36 strikeouts this season. This will be Tidwell’s second career game against the St. Louis Cardinals.

Why the San Francisco Giants will win

  • The Giants have won each of their last five games as underdogs against the Cardinals following a win.
  • The Cardinals have lost each of their last five Wednesday games as favorites against NL West opponents.
  • The underdogs have covered the run line in each of the last 11 games between the Cardinals and Giants.
  • The Cardinals have failed to cover the run line in 19 of their last 22 games as favorites against NL West opponents.
  • The Cardinals have lost the first inning in four of their last five games.
  • The Giants have led after 3 innings in five of their last six home games against NL Central opponents.
  • The Giants have led after 5 innings in each of their last six home games against opponents that held a losing record.

Why the St. Louis Cardinals will win

  • The Giants have lost each of their last eight day games following a win.
  • The Cardinals have won 13 of their last 16 day games against the Giants following a loss.
  • The Giants have failed to cover the run line in each of their last eight day games against NL Central opponents following a home win.
  • The Cardinals have covered the run line in seven of their last eight day games against the Giants following a loss.
  • The Cardinals have led after 3 innings in four of their last five road day games.
  • The Cardinals have led after 5 innings in each of their last six road day games.

Total Runs Facts

  • Each of the Cardinals’ last four day games against NL West opponents have gone OVER the total runs line.
  • Each of the Giants’ last three games as underdogs against the Cardinals have gone UNDER the total runs line.
  • There has been at least one run scored in the first inning in each of Blade Tidwell’s last six appearances as a starter.
  • There has been at least one run scored in the first inning in seven of the Cardinals’ last eight day games against NL opponents.

San Francisco Giants Player Prop Facts

  • Rafael Devers has hit a home run in four of the Giants’ last five home games against opponents that held a losing record.
  • Blade Tidwell has recorded five or more strikeouts in three of his last four appearances with the Giants as underdogs.
  • Drew Gilbert has recorded at least one hit in each of his last eight home appearances against NL opponents that held a losing record.
  • Rafael Devers ranks 8th in the league in Home Runs (35) this season.

St. Louis Cardinals Player Prop Facts

  • Alec Burleson has hit a home run in two of the Cardinals’ last three days’ games against NL West opponents that held a losing record.
  • Andre Pallante has recorded five or more strikeouts in seven of his last eight appearances against opponents that held a losing record.
  • Ivan Herrera has recorded at least one hit in each of the Cardinals’ last 15 games against NL West opponents that held a losing record.
  • Jordan Walker ranks T8th in the league in Hits (157) this season.

Matchup/League Facts

  • The Giants rank 1st in the league for home runs allowed this season (139).
  • The Giants rank 29th in the league for walks this season (405).
  • The Cardinals rank 26th in the league for slugging percentage this season (.385).
  • The Cardinals rank 26th in the league for opponent batting average this season (.254).

Giants vs Cardinals Prediction

I’m not excited to lay juice on either of these teams, but Pallante has been the better arm, and he’s been on a tear lately, allowing 19 hits and 6 runs in his last 22.1 innings. Tidwell has allowed 17 runs in his last 30.2 innings, and the Giants haven’t won a game with him on the mound since April. The Giants have lost 8 straight games Tidwell has pitched. The price isn’t crazy. Give me the Cardinals with the better arm on the mound.

Randy Chambers's Free Pick: St. Louis Cardinals -126

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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