Giants vs Cubs Prediction 6/5/26 MLB Picks Today

In this article, we will formulate a Giants vs Cubs Prediction for this MLB matchup on Friday, June 5^th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 33-30 record this season and are sitting in the 4th place of the NL Central. They have a 19-13 home record and are coming off a 7-6 home win against the Athletics. They will face the Rockies and the Nationals next.

The Cubs have a .240 batting average this season, .333 OBP and .391 Slugging percentage. Chicago’s pitching staff has a 4.17 ERA and 1.23 WHIP. Alex Bregman is the team’s best hitter with a .255 batting average. Michael Busch leads the team in RBI with 36, while Ian Happ adds a team-high 14 home runs.

Edward Cabrera (R) is the projected starting pitcher for the Cubs, and he has a 3-2 record, 4.00 ERA and 1.35 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 25-38 record this season and are sitting in the 4th place of the NL West. They have a 13-22 road record and are coming off a 12-9 road win against the Brewers. They will face the Nationals and the Rockies next.

The Giants have a .256 batting average this season, .304 OBP and .408 Slugging percentage. San Francisco’s pitching staff has a 4.58 ERA and 1.41 WHIP. Luis Arraez is the team’s best hitter with a .325 batting average. Casey Schmitt leads the team in RBI with 35, adding a team-high 13 home runs.

Robbie Ray (L) is the projected starting pitcher for the Giants, and he has a 3-6 record, 4.45 ERA and 1.40 WHIP.

San Francisco Giants @ the Chicago Cubs Betting Trends: June 5, 2026

• Probable Starting Pitcher: Edward Cabrera      Record this season: 3-2      ERA: 4.00
• Home Record: 2-1
• Last 5 against Giants: 3-0

Why the Chicago Cubs will win

• The Cubs have won each of their last 10 home games against National League opponents that held a losing record.
• The Giants have lost 12 of their last 15 games against National League opponents.
• The Cubs have covered the run line in nine of their last 10 home games against National League opponents that held a losing record.
• The Giants have failed to cover the run line in each of their last six Friday day games.
• The Cubs have led after 3 innings in each of their last six games against NL West opponents.
• The Cubs have led after 5 innings in each of their last eight games as home favorites against NL West opponents.

• Probable Starting Pitcher: Robbie Ray      Record this season: 3-6      ERA: 4.45
• Road Record: 0-5
• Last 5 against Cubs: 3-0

Why the San Francisco Giants will win

• The Cubs have lost seven of their last eight games as home favorites.
• The Giants have won each of their last four games as underdogs against the Cubs.
• The Cubs have failed to cover the run line in each of their last nine home games.
• The Giants have covered the run line in each of their last 10 Friday games as underdogs against NL Central opponents.
• The Giants have won the first inning in three of their last four games against the Cubs.
• The Cubs have trailed after 5 innings in eight of their last nine home games.
• The Giants have led after 3 innings in five of their last six road day games.

Total Runs Facts

• Five of the Giants’ last six games against NL Central opponents have gone OVER the total runs line.
• Each of the Cubs’ last three home games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cubs’ last four day games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Giants’ last six games at Wrigley Field.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit a home run in each of the Cubs’ last three games against NL opponents that held a losing record.
• Edward Cabrera has recorded six or more strikeouts in each of his six previous appearances against NL West opponents that held a losing record.
• Ian Happ has recorded at least one hit in each of his last nine appearances against NL West opponents that held a losing record.
• Edward Cabrera has recorded a win in three of his last four appearances against NL West opponents.

San Francisco Giants Player Prop Facts

• Matt Chapman has hit a home run in each of the Giants’ last two games as underdogs against the Cubs.
• Willy Adames has recorded at least one hit in each of his last nine appearances in day games against NL Central teams that held a winning record.
• Luis Arraez ranks 2nd in the league in Hits (76) this season.

Matchup/League Facts

• The Cubs rank 1st in the league for walks this season (271).
• The Cubs rank T28th in the league for home runs allowed this season (88).
• The Giants rank 1st in the league for doubles this season (129).
• The Giants rank 30th in the league for steals this season (15).

Giants vs Cubs Prediction

The Giants are 8-2 in their last 10 meetings against the Cubs and have won their last two visits in Chicago.

In this Giants vs Cubs Prediction, the Cubs are coming as -165 home favorites. The Cubs are coming off a series loss at home against the A’s while the Giants have won back-to-back games against the Brewers. Both pitchers have 4+ ERA and both are coming off quality starts, so the Cubs are being overvalued in this spot. Chicago has been weaker against lefties, while the Giants are the best teams against righties in the last 10 days, so take the Giants for plus money in this one.