Giants vs Diamondbacks Prediction 9/16/25 MLB Picks Today

In this article, we will formulate a Giants vs Diamondbacks Prediction for this MLB game on Tuesday, September 16^th at the Chase Field in the second game of this series, with the Dbacks having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 76-75 record this season and are sitting on the 4^th place of the NL West. The Diamondbacks have a 39-34 home record and are 72-70 in over/under They are coming off an 8-1 home victory over the Giants, and are 4-1 in their last 5 games. They are playing the Phillies and the Dodgers next.

The Diamondbacks have a .251 batting average this season, .324 OBP and .434 slugging percentage. Arizona’s pitching staff has a 4.45 ERA and 1.32 WHIP. Geraldo Perdomo leads the Diamondbacks with 160 hits, adding a team-high 97 RBI. He Is also the team’s best hitter with a .290 batting average, while Corbin Carroll leads the team in home runs with 30.

Eduardo Rodriguez (L) is the projected starting pitcher for the Diamondbacks, and he has an 8-8 record, 4.98 ERA and 1.55 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 75-75 record this season and are sitting on the third place of the NL West. They have a 37-38 road record and are 71-73 in over/under. They are coming off a 11-5 home victory over the Giants, that ended their two-game losing streak. Over is 7-3 in their last 10 games and are playing the Dodgers and the Cardinals next.

The Giants have a .237 batting average this season, .312 OBP and .388 Slugging percentage. San Francisco’s pitching staff has a 3.75 ERA and 1.29 WHIP.  Heliot Ramos leads the Giants with 148 hits, while Jung Hoo Lee is the team’s best hitter, with a .264 batting average. Willy Adames leads the team in RBI with 82, adding a team-high 28 home runs.

The Giants have not yet announced a starting pitcher for this game.

San Francisco Giants @ Arizona Diamondbacks Betting Trends: September 16, 2025

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 8-8      ERA: 4.98
• Home Record: 2-2
• Last 5 against Giants: 2-1

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last six night games at Chase Field following a win.
• The Giants have lost each of their last four games after playing the previous day.
• The Diamondbacks have covered the run line in each of their last seven night games following a win.
• The Giants have failed to cover the run line in each of their last four games as road underdogs against NL West opponents.
• The Diamondbacks have led after 3 innings in five of their last six games as favorites.
• The Diamondbacks have led after 5 innings in 12 of their last 13 home games against National League opponents.
• The Diamondbacks have won the first inning in each of their last 12 home games against National League opponents.

• Probable Starting Pitcher: TBD

Why the San Francisco Giants will win

• The underdogs have won seven of the Diamondbacks’ last nine games at Chase Field.
• The Diamondbacks have lost three of their last four games as favorites against NL West opponents.
• The Giants have covered the run line in each of their last four games following a road loss.
• The Diamondbacks have failed to cover the run line in 10 of their last 12 games as favorites.
• The Giants have won the first inning in four of their last five games against opponents that held a winning record.
• The Giants have led after 3 innings in each of their last four night games against opponents that held a winning record.
• The Giants have led after 5 innings in three of their last four games at Chase Field against opponents that held a winning record.

Total Runs Facts

• Eight of the Giants’ last 10 night games after playing the previous day have gone OVER the total runs line.
• Four of the Diamondbacks’ last five games as favorites against the Giants have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last 12 home games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last four night games.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last 16 games as favorites.
• Eduardo Rodriguez has recorded five or more strikeouts in 16 of his 21 previous appearances with his team as a home favorite against NL opponents.
• Eduardo Rodriguez has recorded a win in each of his last three appearances.
• James McCann has hit a home run in three of his last four appearances with his team as a favorite against the Giants.
• Corbin Carroll has recorded a Double in four of the Diamondbacks’ last five home games against NL opponents.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in three of the Giants’ last five road games against NL West opponents.
• Wilmer Flores has recorded at least one hit in each of the Giants’ last nine Tuesday games against opponents that held a winning record.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (36).
• The Diamondbacks rank 3rd in the league for RBIs this season (730).
• The Giants rank 1st in the league for home runs allowed this season (128).
• The Giants rank 29th in the league for steals this season (65).

Giants vs Diamondbacks Prediction

The Giants are 4-2 in their last 6 meetings against the Diamondbacks, but both teams are tied 2-2 wins in their last 4 meetings Arizona. Over is 7-3 in their last 10 meetings.

In this Giants vs Diamondbacks Prediction, the Diamondbacks are coming as -125 home favorites. Both teams are coming in completely opposite forms, as the Dbacks have been playing good baseball and are playing at home. On top of that, Rodriguez is currently on his best stretch of the season, as he has just one earned runs in his last three starts. Arizona also has the 5^th-best offense in baseball, and given how poor the Giants are playing and the uncertainty behind their starting pitcher, I will side with the home team in this matchup.