Giants vs Dodgers Prediction 9/12/25 MLB Picks Today

The Los Angeles Dodgers and San Francisco Giants meet Friday in MLB action at Oracle Park. Here’s a Giants vs Dodgers Prediction. This article will include a Giants vs Dodgers Pick.

Los Angeles Dodgers Betting Preview

The Los Angeles Dodgers are 82-64 on the year and play the Phillies, Giants, and Diamondbacks next. The Los Angeles Dodgers are batting .252 on the season, have a .328 OBP, and a .437 slugging percentage. The Los Angeles Dodgers pitching staff has a 4.03 ERA and a 1.27 WHIP. Shohei Ohtani leads the Los Angeles Dodgers with 154 hits and 92 RBI, while Freddie Freeman and Andy Pages have combined for 288 hits and 159 RBI.

Yoshinobu Yamamoto gets the ball for the Los Angeles Dodgers, and he is 11-8 with a 2.72 ERA and 177 strikeouts this season. Yamamoto is 0-1 with a 4.67 ERA and 17 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 74-72 on the year and play the Diamondbacks, Dodgers, and Cardinals next. The San Francisco Giants are batting .239 on the season, have a .314 OBP, and a .392 slugging percentage. The San Francisco Giants pitching staff has a 3.76 ERA and a 1.29 WHIP. Heliot Ramos leads the San Francisco Giants with 147 hits and 61 RBI while Jung Hoo Lee and Willy Adames have combined for 261 hits and 133 RBI.

Justin Verlander gets the ball for the San Francisco Giants, and he is 3-10 with a 4.09 ERA and 120 strikeouts this season. Verlander is 3-1 with a 3.38 ERA and 33 strikeouts in his career against the Los Angeles Dodgers.

Los Angeles Dodgers @ San Francisco Giants Betting Trends: September 12, 2025

• Probable Starting Pitcher: Justin Verlander      Record this season: 3-10      ERA: 4.09
• Home Record: 2-6
• Last 5 against Dodgers: 2-2

Why the San Francisco Giants will win

• The Dodgers have lost each of their last six games as road favorites following a win.
• The Giants have won five of their last six games as underdogs against National League opponents.
• The Dodgers have failed to cover the run line in each of their last eight road games following a win.
• The Giants have covered the run line in each of their last seven games as underdogs against National League opponents.
• The Giants have won the first inning in each of their last five Friday games.
• The Dodgers have trailed after 5 innings in five of their last six road games against National League opponents.
• The Dodgers have trailed after 3 innings in each of their last four road games against National League opponents.

• Probable Starting Pitcher: Yoshinobu Yamamoto      Record this season: 11-8      ERA: 2.72
• Road Record: 8-4
• Last 5 against Giants: 0-1

Why the Los Angeles Dodgers will win

• The Giants have lost each of their last 10 home games against National League opponents following a home loss.
• The Dodgers have won seven of their last eight games against the Giants following a home win.
• The Giants have failed to cover the run line in each of their last 13 home games against National League opponents following a home loss.
• The Dodgers have covered the run line in each of their last four games.
• The Giants have trailed after 5 innings in each of their last five games as home underdogs against NL West opponents.
• The Dodgers have led after 3 innings in four of their last five games.

Total Runs Facts

• Each of the Giants’ last five night games against NL West opponents have gone OVER the total runs line.
• Four of the Dodgers’ last five road games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Dodgers’ last eight night games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Giants’ last eight home games.

San Francisco Giants Player Prop Facts

• Matt Chapman has hit at least one home run in each of his last three appearances with the Giants as home underdogs against NL opponents.
• Justin Verlander has recorded five or more strikeouts in each of his last eight home appearances.
• Jung Hoo Lee has recorded at least one hit in each of his last 12 appearances after not playing the previous day.
• Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.378) this season.

Los Angeles Dodgers Player Prop Facts

• Mookie Betts has hit a home run in three of the Dodgers’ last four games.
• Freddie Freeman has recorded at least one Double in three of the Dodgers’ last four games as road favorites against the Giants.
• Miguel Rojas has recorded at least one hit in each of his last seven appearances against the Giants after not playing the previous day.
• Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.609) this season.

Matchup/League Facts

• The Giants rank 1st in the league for home runs allowed this season (125).
• The Giants rank 29th in the league for steals this season (64).
• The Dodgers rank 2nd in the league for home runs this season (215).
• The Dodgers rank 2nd in the league for RBIs this season (708).

Giants vs Dodgers Prediction

The Dodgers are going to be favored for obvious reasons, as they’re the better, more consistent team and Yamamoto has been the better pitcher. However, the value is with the Giants at home and the plus money. The Giants need wins to sneak into the playoffs and while Verlander has been a shell of himself for much of the season, he hasn’t allowed a run in his last 11 innings.

Verlander has allowed 35 hits and 13 earned runs in his last 38.1 innings. Verlander has been a big game pitcher throughout his Hall of Fame career, and he’s pitched his best over his last three starts as the playoff chase is heating up. I’ll take a stab with the Giants and the more favorable price.