Giants vs Mariners Prediction 4/5/25 MLB Picks Today

The Seattle Mariners and the San Francisco Giants meet Saturday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Seattle Mariners will start Bryce Miller here and Miller is 0-1 with a 4.76 ERA and 4 strikeouts this season. This will be Miller’s first career start against the Giants. The San Francisco Giants will give the nod to Robbie Ray here and Ray is 1-0 with a 5.06 ERA and 4 strikeouts this season. In his last five starts against the Mariners, Ray is 1-0 with a 2.89 ERA and 37 strikeouts.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from a 10-9 loss at the hands of the Giants in Friday’s series opener to fall to 3-5 on the year. After this series, the Mariners will return home for a series with the Houston Astros.

Mariners Looking To Get Back On Track

Jorge Polanco leads the Mariners with 9 hits including a pair of home runs and 8 RBIs while Victor Robles has 8 hits with a team-high 3 doubles. Randy Arozarena has 4 hits with a pair of doubles and a pair of home runs but also leads Seattle with 11 strikeouts as well on the year. Julio Rodriguez has chipped in 7 hits with 2 home runs and a triple and a team-high 3 stolen bases while Cal Raleigh and Ryan Bliss have each added a pair of stolen bags as well on the year.

Why the Seattle Mariners will win

• The Giants have lost each of their last five games as favorites against AL West opponents following a home win.
• The Mariners have won four of their last five games as underdogs following a loss.
• The road team has covered the run line in each of the Giants’ last 10 games.
• The Giants have failed to cover the run line in 10 of their last 11 night games against American League opponents following a home win.

Seattle Mariners Player Prop Facts

• Julio Rodriguez has hit a home run in each of the Mariners’ last three games against opponents that held a winning record.
• Randy Arozarena has recorded a Double in three of the Mariners’ last four games as underdogs.
• Cal Raleigh has recorded at least one Single in each of the Mariners’ last seven games against opponents that held a winning record.
• Bryce Miller has recorded a win in four of his last five road appearances against opponents that held a winning record.
• Julio Rodriguez has scored at least one run in each of the Mariners’ last six games against opponents that held a winning record.
• Bryce Miller has recorded five or more strikeouts in five of his last six appearances with the Mariners as underdogs.
• Julio Rodriguez has recorded at least one hit in each of the Mariners’ last 17 road games.
• Luke Raley has recorded at least one RBI in four of his last five appearances against NL West opponents.
• Julio Rodriguez ranks T7th in the league in Steals (3) this season.

San Francisco Giants Recap

The San Francisco Giants will try to keep the momentum going after a thrilling win over the Mariners in Friday’s opener to improve to 6-1 on the year. After this game, the Giants will welcome the Cincinnati Reds to town for an interleague series.

Giants Win 5^th Straight

Heliot Ramos leads the Giants with 10 hits including a team-high 3 doubles along with 3 home runs and 8 RBIs but also leads the Giants with 12 strikeouts so far this season while Wilmer Flores has a team-high 4 home runs and 10 RBIs as well this season. Jung Hoo Lee also has a team-high 3 doubles while Lamonte Wade Jr. has 4 hits with 2 doubles, a triple and a home run. Willy Adames has also contributed 6 hits with a pair of doubles and 6 RBIs and Matt Chapman’s added a pair of homers and 6 RBIs as well this season.

Why the San Francisco Giants will win

• The Giants have won each of their last seven games against American League opponents.
• The Mariners have lost each of their last four road games against NL West opponents that held a winning record.
• The Giants have covered the run line in each of their last eight night games against American League opponents.
• The Mariners have failed to cover the run line in seven of their last eight games as road underdogs against NL West opponents following a loss.

San Francisco Giants Player Prop Facts

• Heliot Ramos has hit a home run in three of the Giants’ last four games as favorites.
• Jung Hoo Lee has recorded a Double in each of his last four appearances after playing the previous day.
• Heliot Ramos has recorded at least one RBI in each of the Giants’ last four games as favorites.
• Matt Chapman has recorded a Single in each of the Giants’ last six games against opponents that held a losing record.
• Willy Adames has scored at least one run in each of his last six appearances against AL West opponents that held a losing record.
• Jung Hoo Lee has recorded at least one hit in each of his last nine appearances after playing the previous day.
• Wilmer Flores ranks T4th in the league in Home Runs (4) this season.

Total Runs Facts

• Five of the Giants’ last six games as favorites against AL West opponents have gone UNDER the total runs line.
• Four of the Mariners’ last five games after playing the previous day have gone UNDER the total runs line.

Seattle Mariners vs. San Francisco Giants Prediction

I’m on the Giants in this game. The Mariners had an odd offensive explosion in Friday’s opener but I’m not trusting that to be sustainable against the Giants two days in a row. The Mariners weren’t great offensively last year, and haven’t been great this year either, but last year, the Mariners also stunk against left-handed pitching. This year, the Mariners have struck out early and often against southpaws, which should bode well against a strikeout artist like Robbie Ray. I think the Giants go for the sweep on Sunday, so give me San Francisco to get the win on Saturday.