Giants vs Padres Prediction 8/18/25 MLB Picks Today

In this article, we will formulate a Giants vs Padres Prediction for this MLB game on Monday, August 18^th at the Petco Park in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 69-55 record this season and are sitting on the second place of the NL West. They have a 38-20 home record, and are 51-69 in over/under. The Padres are coming off a 4-5 road defeat by the Dodgers, and have three consecutive losses. Under is 4-1-1 in their last 6 games and are playing the Dodgers and the Mariners next.

The Padres have a .252 batting average this season, .322 OBP and .383 Slugging percentage. San Diego’s pitching staff has a 3.57 ERA and 1.20 WHIP. Luis Arraez leads the Padres with 140 hits and team-high .291 batting average. Manny Machado leads the team in RBI, with 72, adding a team-high 20 home runs.

Nestor Cortes (L) is the projected starting pitcher for the Padres, and he has a 1-1 record, 5.71 ERA and 1.56 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 60-64 record this season and are sitting on the third place of the NL West. They have a 30-31 road record and are 57-62 in over/under. They are coming off a 7-1 home victory over the Rays, which ended their previous seven-game losing streak. Under is 6-3-1 in their last 10 games and are playing the Cubs and the Brewers next.

The Giants have a .233 batting average this season, .309 OBP and .374 Slugging percentage. San Francisco’s pitching staff has a 3.70 ERA and 1.28 WHIP.  Heliot Ramos leads the Giants with 126 hits and is the team’s best hitter, with a .265 batting average. Willy Adames leads the team in RBI with 62, adding a team-high 19 home runs.

Robbie Ray (L) is the projected starting pitcher for the Giants, and he has a 9-6 record, 2.98 ERA and 1.14 WHIP.

Why the San Diego Padres will win

• The Padres have won each of their last 11 games at Petco Park following a loss.
• The Giants have lost each of their last six night games against the Padres following a win.
• The Padres have covered the run line in each of their last six night games against the Giants following a loss.
• The Giants have failed to cover the run line in each of their last six night games against the Padres following a win.
• The Giants have lost the first inning in five of their last six night games at Petco Park.
• The Giants have trailed after 3 innings in four of their last five games against National League opponents.
• The Giants have trailed after 5 innings in six of their last seven games as underdogs against NL West opponents.

Why the San Francisco Giants will win

• The Padres have lost each of their last seven night games against the Giants at Petco Park following a road loss.
• The Giants have won four of their last five games as road underdogs.
• The Padres have failed to cover the run line in seven of their last eight home games against National League opponents that held a losing record.
• The road team has covered the run line in each of the last four games between the Giants and Padres.
• The Giants have led after 5 innings in each of their last four road night games.
• The Padres have lost the first inning in three of their last four night games against National League opponents that held a losing record.
• The Giants have led after 3 innings in each of their last four road night games.

Total Runs Facts

• Eight of the last nine games between the Giants and Padres at Petco Park have gone OVER the total runs line.
• Five of the Giants’ last six road games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last nine Monday games at Petco Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last six night games between the Giants and Padres at Petco Park.

Matchup/League Facts

• The Padres rank 1st in the league for opponent batting average this season (.226).
• The Padres rank 1st in the league for hits allowed this season (915).
• The Giants rank 1st in the league for home runs allowed this season (107).
• The Giants rank 29th in the league for steals this season (56).

Giants vs Padres Prediction

The Padres are 8-2 in their last 10 meetings against the Giants, having won their last two meetings in San Diego. Under is 5-2 in their last 7 meetings.

In this Giants vs Padres Prediction, the Padres are coming as -140 home favorites. The Padres have a better overall record and have been very strong at home. They are putting Cortes on the mound, who is finally getting in shape, with only three earned runs across his last three starts. On the flip side, Ray has been excellent for the Giants this season, and in the previous game that both these pitchers started, both teams combined for 6 total runs, as the game went under the total. Both teams are also terrible against lefties, averaging 6.5 runs per game combined against left-handed pitching, and also have the two best bullpens in the league. This is going to be an extremely low-scoring game, so take the under 7.5 runs.