San Diego Padres (35-25) vs. San Francisco Giants (34-28)
June 5, 2025 3:45 pm EDT
The Line: San Francisco Giants -120 / San Diego Padres 100; Over/Under: 7
(Get latest betting odds)
In this article, we will formulate a Giants vs Padres prediction for this MLB game on Thursday, June 5, at Oracle Park in San Francisco, California. Let’s take a look at the prediction for this MLB matchup.
San Diego Padres Betting Preview
The San Diego Padres (35-25, 15-15 Away) won the last three series as they defeated the Braves, Marlins, and Pirates. They opened the current four-game series against the Giants with a couple of victories, but lost Game 3 on Wednesday. In that 6-5 defeat, Gavin Sheets led the team with four RBI, while Nick Pivetta pitched for 6.0 innings in a no-decision, allowing five runs on six hits with five strikeouts and one walk. Jason Adam took the loss.
This season, the Padres average 4.18 runs per game (17th in the MLB) on a .249/.315/.381 triple-slash. When it comes to pitching, the Padres’ staff has a 3.56 ERA (8th) and 1.20 WHIP (8th). Gavin Sheets leads the Padres with a .263 batting average, 11 home runs, and 38 RBI this season.
Dylan Cease will take the mound for the Padres on Thursday. The 29-year-old right-hander has a 1-4 record in 12 starts this year with a 4.66 ERA and 1.29 WHIP in 63.2 innings.
San Francisco Giants Betting Preview
The San Francisco Giants (35-28, 18-11 Home) were swept by the Detroit Tigers and defeated the Miami Marlins prior to this series against the Padres. San Francisco lost the first two games but responded with a 6-5 victory in Game 3 last night. Heliot Ramos and Matt Chapman led the offense with two RBI apiece, while Kyle Harrison pitched for 4.1 innings in a no-decision, allowing five runs on nine hits with three strikeouts and one walk. Sean Hjelle was credited with the win.
This year, the Giants average 4.13 runs per game (20th in the MLB) on a .231/.309/.372 triple-slash. When it comes to pitching, the Giants’ staff has a 3.06 ERA (2nd) and 1.20 WHIP (10th). Wilmer Flores leads the Giants with a .250 batting average, ten home runs, and 47 RBI this season.
The projected starting pitcher for the Giants is Robbie Ray, who is 7-1 in 12 starts this season, with a 2.43 ERA and 1.11 WHIP in 70.1 innings.
Why the Giants will beat the Padres
- The Giants have won five of their last six home games against NL West opponents following a home win.
- The Giants have covered the run line in five of their last six day games against NL West opponents.
- The Giants have led after 5 innings in four of their last five games as favorites against NL West opponents.
Total Runs Facts
- Each of the Giants’ last seven games as favorites against National League opponents have gone UNDER the total runs line.
- Five of the Padres’ last six games as underdogs against National League opponents have gone UNDER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last five day games.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Padres’ last 10 games as road underdogs.
Matchup/League Facts
- The Giants are one of only four teams in the league to rank top 10 in both strikeouts and walks allowed this season.
- The Giants rank 5th in the league for runs allowed this season (215).
- The Padres rank 5th in the league for opponent batting average this season (.226).
- The Padres rank T25th in the league for home runs this season (53).
Padres vs Giants Prediction
The Padres won seven of the previous ten H2H encounters, including four of five this season. In this one, however, I am backing the Giants, mainly because of Robbie Ray, who is San Francisco’s ace thus far in the season. Ray was one of the best starters in May in the entire MLB, posting a 1.38 ERA in 39.0 innings. Ray allowed more than one run in just one game in that span. Dylan Cease, on the other hand, surrendered three runs in each of his last three starts, and I believe that Ray has an advantage here. Back the Giants to win and split the series.
