Giants vs Padres Prediction 9/12/26 MLB Picks Today
San Diego Padres (79-68) vs. San Francisco Giants (62-86)
September 12, 2026 4:05 pm EDT
The Line: San Francisco Giants 132 / San Diego Padres -160; Over/Under: 8
(Get latest betting odds)
The San Diego Padres and San Francisco Giants meet Saturday in MLB action at Oracle Park. Here’s a Giants vs. Padres Prediction. This article will include a Giants vs. Padres Pick.
San Diego Padres Betting Preview
The San Diego Padres are 79-68 on the year and play the Rockies and Marlins next. The San Diego Padres are batting .238 on the season, have a .315 OBP, and have a .388 slugging percentage. The San Diego Padres’ pitching staff has a 3.88 ERA and a 1.28 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 161 hits and 72 RBI, while Jackson Merrill and Manny Machado have combined for 253 hits and 159 RBI.
Michael King gets the ball for the San Diego Padres, and he is 10-9 with a 3.00 ERA and 144 strikeouts this season. King is 3-1 with a 2.22 ERA and 27 strikeouts in his career against the San Francisco Giants.
San Francisco Giants Betting Preview
The San Francisco Giants are 62-86 on the year and play the Cardinals and Dodgers next. The San Francisco Giants are batting .248 on the season, have a .309 OBP, and have a .407 slugging percentage. The San Francisco Giants’ pitching staff has a 4.34 ERA and a 1.36 WHIP. Rafael Devers leads the San Francisco Giants with 142 hits and 92 RBI, while Jung Hoo Lee and Willy Adames have combined for 249 hits and 106 RBI.
Cesar Perdomo gets the ball for the San Francisco Giants, and he is 0-0 with a 0.90 ERA and 8 strikeouts this season. This will be Perdomo’s first career game against the San Diego Padres.
Why the San Francisco Giants will win
- The Padres have lost each of their last four games as favorites following a road win.
- The Giants have won four of their last five games as home underdogs following a loss.
- The Giants have covered the run line in each of their last four games as underdogs against the Padres following a loss.
- The Padres have failed to cover the run line in six of their last seven games after playing the previous day.
- The Giants have won the first inning in each of their last five home games.
- The Padres have trailed after 5 innings in three of their last four road day games.
Why the San Diego Padres will win
- The Padres have won each of their last 11 day games against NL West opponents that held a losing record.
- The Giants have lost each of their last seven day games against NL West opponents that held a winning record.
- The Padres have covered the run line in 10 of their last 11 day games against NL West opponents that held a losing record.
- The Giants have failed to cover the run line in each of their last four home games against the Padres following a home loss.
- The Padres have led after 5 innings in each of their last seven Saturday games against NL West opponents that held a losing record.
- The Padres have led after 3 innings in four of their last five games.
Total Runs Facts
- Four of the Giants’ last five home games have gone OVER the total runs line.
- Four of the Padres’ last five games as favorites against NL West opponents have gone OVER the total runs line.
- There has been no run scored during the first inning in each of the Padres’ last seven day games against NL West opponents.
- There has been no run scored during the first inning in each of the Giants’ last eight Saturday games at Oracle Park.
San Francisco Giants Player Prop Facts
- Rafael Devers has recorded at least one hit in each of the Giants’ last 10 games against NL West opponents.
- Rafael Devers has hit a home run in each of the Giants’ last two games against the Padres.
San Diego Padres Player Prop Facts
- Michael King has recorded six or more strikeouts in each of his three previous appearances with the Padres as favorites against the Giants.
- Fernando Tatis Jr. has recorded at least one hit in each of the Padres’ last 11 games as road favorites.
- Xander Bogaerts has hit a home run in two of the Padres’ last three road games against the Giants.
- Michael King has recorded a win in four of his last five appearances against NL West opponents that held a losing record.
Matchup/League Facts
- The Giants rank 1st in the league for home runs allowed this season (140).
- The Giants rank 29th in the league for walks this season (412).
- The Padres rank 4th in the league for steals this season (144).
- The Padres rank 26th in the league for hits this season (1154).
Giants vs Padres Prediction
We’re getting a low price on the Padres, who are fighting for their playoff lives and playing a Giants side that’s been eyeing a vacation for months. King has been solid this season and even better lately, allowing 33 hits and 9 earned runs in his last 42.2 innings. King looks like an All-Star right now. Perdomo has just 10 career innings under his belt, and I like sample sizes with my pitchers. I have no idea what I’m getting from Perdomo. I’ll gladly back the Padres at this price as they need wins to lock up a wild card berth.