Giants vs Pirates Prediction 5/10/26 MLB Picks Today
Pittsburgh Pirates (22-18) vs. San Francisco Giants (15-24)
May 10, 2026 4:05 pm EDT
The Line: San Francisco Giants -118 / Pittsburgh Pirates -102; Over/Under: 8
(Get latest betting odds)
The Pittsburgh Pirates and San Francisco Giants meet Sunday in MLB action at Oracle Park. Here’s a Giants vs. Pirates Prediction. This article will include a Giants vs. Pirates Pick.
Pittsburgh Pirates Betting Preview
The Pittsburgh Pirates are 22-18 on the year and play the Rockies and Phillies next. The Pittsburgh Pirates are batting .251 on the season and have a .337 OBP, and a .391 slugging percentage. The Pittsburgh Pirates’ pitching staff has a 3.73 ERA and a 1.22 WHIP. Nick Gonzales leads the Pittsburgh Pirates with 42 hits and 17 RBI, while Ryan O’Hearn and Oneil Cruz have combined for 81 hits and 54 RBI.
Bubba Chandler gets the ball for the Pittsburgh Pirates, and he is 1-4 with a 4.76 ERA and 31 strikeouts this season. This will be Chandler’s first career game against the San Francisco Giants.
San Francisco Giants Betting Preview
The San Francisco Giants are 15-24 on the year and play the Dodgers and Athletics next. The San Francisco Giants are batting. 241 on the season, have a .284 OBP, and have a .357 slugging percentage. The San Francisco Giants pitching staff has a 4.07 ERA and a 1.33 WHIP. Luis Arraez leads the San Francisco Giants with 44 hits and 13 RBI while Heliot Ramos and Jung Hoo Lee have combined for 76 hits and 28 RBI.
Tyler Mahle gets the ball for the San Francisco Giants, and he is 1-4 with a 5.00 ERA and 34 strikeouts this season. Mahle is 5-4 with a 3.84 ERA and 70 strikeouts in his career against the Pittsburgh Pirates.
Why the San Francisco Giants will win
- The Giants have won each of their last five day games against NL Central opponents that held a winning record.
- The Pirates have lost four of their last five games against NL West opponents following a win.
- The favorites have covered the run line in each of the last four games between the Pirates and Giants.
- The Pirates have failed to cover the run line in four of their last five games against NL West opponents following a win.
- The Giants have led after 5 innings in each of their last five Sunday games against the Pirates at Oracle Park.
- The Giants have led after 3 innings in each of their last six Sunday games against the Pirates.
Why the Pittsburgh Pirates will win
- The Giants have lost 11 of their last 12 games as favorites against National League opponents following a home loss.
- The Pirates have won four of their last five games as road underdogs against the Giants.
- The Giants have failed to cover the run line in 15 of their last 16 games as favorites against National League opponents following a home loss.
- The road team has covered the run line in eight of the last 10 games between the Pirates and Giants.
- The Giants have trailed after 3 innings in three of their last four home day games.
- The Pirates have led after 5 innings in eight of their last nine day games against NL West opponents that held a losing record.
Total Runs Facts
- Each of the Giants’ last seven day games against NL Central opponents have gone UNDER the total runs line.
- Four of the Pirates’ last five games after playing the previous day have gone UNDER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last eight day games at Oracle Park.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Pirates’ last nine games at Oracle Park.
San Francisco Giants Player Prop Facts
- Tyler Mahle has recorded five or more strikeouts in 11 of his last 12 home appearances against NL Central opponents.
- Tyler Mahle has recorded a win in six of his last eight appearances in day games against NL Central teams that held a winning record.
- Luis Arraez has recorded at least one hit in each of his last 15 home appearances against NL opponents that held a winning record.
- Rafael Devers has hit a home run in each of the Giants’ last two games as favorites.
Pittsburgh Pirates Player Prop Facts
- Marcell Ozuna has recorded at least one hit in each of his last seven appearances in day games.
- Brandon Lowe has hit at least one home run in two of the Pirates’ last three day games against opponents that held a losing record.
Matchup/League Facts
- The Giants rank 30th in the league for runs scored this season (123).
- The Giants rank 30th in the league for RBIs this season (118).
- The Pirates rank 2nd in the league for home runs allowed this season (31).
- The Pirates rank 3rd in the league for on-base percentage this season (.337).
Giants vs Pirates Prediction
We were on the over yesterday in the Pirates – Giants, and I’m going to do the same here. Chandler has had control issues and he has a 5.30 ERA in 18.2 innings on the road. Mahle has a 5.00 ERA and 1.53 WHIP through 36 innings. Two struggling pitchers and a big park, the offense should continue to pour in. Reasonable total. Give me the over.