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Giants vs Rockies Prediction 9/3/25 MLB Picks Today

Giants vs Rockies
September 3, 2025 8:40 pm EDT
The Line: Rockies +195 / Over/Under: 11
(Get latest betting odds)

In this article, we will formulate a Giants vs Rockies Prediction for this MLB game on Wednesday, September 3rd at the Coors Field in the third game of this series, with the Giants having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

Colorado Rockies Preview

The Colorado Rockies have a 39-100 record this season and are sitting on the last place of the NL West. The Rockies have a 22-49 home record and are 60-75 in over/under. They are coming off a 4-7 home defeat by the Giants, and are 1-6 in their last 7 games. Under is 7-3 in their last 10 games and are playing the Dodgers and the Padres next.

The Rockies have a .240 batting average this season, .297 OBP and .393 Slugging percentage. Colorado’s pitching staff has a 5.98 ERA and 1.60 WHIP. Hunter Goodman leads the Rockies with 126 hits, also leading the team both in RBI, with 80, and in home runs, with 27. He is also the team’s best hitter with a .277 batting average.

German Marquez (R) is the projected starting pitcher for the Rockies, and he has a 3-12 record, 6.14 ERA and 1.69 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 70-69 record this season and are sitting on the third place of the NL West. They have a 35-35 road record and are 65-68 in over/under. They are coming off a 7-4 road victory over the Rockies, and are 9-1 in their last 10 games. Over is 4-1 in their last 5 games and are playing the Cardinals and the Diamondbacks next.

The Giants have a .237 batting average this season, .313 OBP and .387 Slugging percentage. San Francisco’s pitching staff has a 3.76 ERA and 1.29 WHIP.  Heliot Ramos leads the Giants with 140 hits and is the team’s best hitter, with a .267 batting average. Wilmer Flores leads the team in RBI with 75, while Willy Adames adds a team-high 26 home runs.

Robbie Ray (L) is the projected starting pitcher for the Giants, and he has a 10-6 record, 3.18 ERA and 1.16 WHIP.

Why the St. Louis Cardinals will win

  • The Athletics have lost four of their last five games.
  • The Cardinals have won each of their last three night games after playing the previous day.
  • The Athletics have failed to cover the run line in four of their last five games.
  • The Cardinals have covered the run line in four of their last five games as favorites against American League opponents.
  • The Cardinals have led after 3 innings in six of their last seven games as favorites against American League opponents.
  • The Cardinals have led after 5 innings in four of their last five games as favorites against American League opponents.

Why the Athletics will win

  • The Athletics have won each of their last six games as road underdogs following a loss.
  • The Cardinals have lost each of their last eight Wednesday games as favorites.
  • The Cardinals have failed to cover the run line in each of their last 12 games as favorites following a home win.
  • The Athletics have covered the run line in each of their last eight road games following a loss.
  • The Cardinals have trailed after 5 innings in each of their last eight night games at Busch Stadium against American League opponents.
  • The Cardinals have lost the first inning in 10 of their last 12 night games against American League opponents.
  • The Athletics have led after 3 innings in each of their last five night games against opponents that held a losing record.

Total Runs Facts

  • Nine of the Cardinals’ last 10 games as favorites against AL West opponents have gone OVER the total runs line.
  • Six of the Athletics’ last seven games as underdogs have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Athletics’ last 10 games as underdogs against National League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last four games between the Athletics and Cardinals.

Matchup/League Facts

  • The Cardinals rank 30th in the league for triples this season (6).
  • The Cardinals rank 29th in the league for strikeouts this season (1031).
  • The Athletics rank 2nd in the league for doubles this season (259).
  • The Athletics rank 29th in the league for home runs allowed this season (197).

Giants vs Rockies Prediction

The Giants are 10-2 in their last 12 head-to-head meetings against the Rockies, and are 4-1 in their last 5 visits in Colorado. Over is 5-1-1 in their last 7 meetings.

In this Giants vs Rockies Prediction, the Giants are coming as -230 road favorites. Ray takes the mound for the Giants, and while he had some bad starts lately, he has been better on the road, with a 3.02 road ERA. On the flip side, Marquez has been weaker at home for the Rockies, with a 6.36 home ERA, and in his only previous start against the Giants this season, he was torched for 5 earned runs in 4.1 innings pitched. The Giants also have the second-best bullpen ERA in the league, and are better against right-handed pitching, so I expect them to keep dominating the inferior Rockies team by 2+ runs once again today.

Nikos Lagouretos's Free Pick: San Francisco Giants -1.5

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