Giants vs Twins Prediction 9/22/26 MLB Picks Today
Minnesota Twins (73-84) vs. San Francisco Giants (65-92)
September 22, 2026 9:45 pm EDT
The Line: San Francisco Giants 109 / Minnesota Twins -131; Over/Under: 7.5
(Get latest betting odds)
The Minnesota Twins and San Francisco Giants meet Tuesday in MLB action at Oracle Park. Here’s a Giants vs. Twins Prediction. This article will include a Giants vs. Twins Pick.
Minnesota Twins Betting Preview
The Minnesota Twins are 73-84 on the year and play the Rangers next. The Minnesota Twins are batting .244 on the season, with a .316 OBP and a .402 slugging percentage. The Minnesota Twins’ pitching staff has a 4.60 ERA and a 1.37 WHIP. Brooks Lee leads the Minnesota Twins with 143 hits and 82 RBI, while Luke Keaschall and Josh Bell have combined for 283 hits and 127 RBI.
Taj Bradley gets the ball for the Minnesota Twins, and he is 11-6 with a 3.81 ERA and 199 strikeouts this season. This will be Bradley’s first career game against the San Francisco Giants.
San Francisco Giants Betting Preview
The San Francisco Giants are 65-92 this year and play the Dodgers next. The San Francisco Giants are batting .247 on the season, have a .308 OBP, and have a .405 slugging percentage. The San Francisco Giants’ pitching staff has a 4.37 ERA and a 1.36 WHIP. Jung Hoo Lee leads the San Francisco Giants with 149 hits and 57 RBI, while Rafael Devers and Willy Adames have combined for 251 hits and 149 RBI.
Anthony Molina gets the ball for the San Francisco Giants, and he is 3-1 with a 4.18 ERA and 25 strikeouts this season. This will be Molina’s second career game against the Minnesota Twins.
Why the San Francisco Giants will win
- The Twins have lost each of their last six road games against NL opponents.
- The home team has won seven of the last eight games between the Twins and Giants.
- The Twins have failed to cover the run line in each of their last eight night games against NL West opponents that held a losing record.
- The underdogs have covered the run line in each of the last seven games between the Twins and Giants.
- The Giants have won the first inning in eight of their last nine night games at Oracle Park.
- The Giants have led after 3 innings in five of their last six games.
- The Giants have led after 5 innings in seven of their last eight home games against opponents that held a losing record.
Why the Minnesota Twins will win
- The Giants have lost seven of their last eight games against AL Central opponents following a win.
- The Twins have won four of their last five road games following a loss.
- The Giants have failed to cover the run line in seven of their last eight games against AL Central opponents following a win.
- The Twins have covered the run line in each of their last five road games following a loss.
- The Twins have led after 3 innings in three of their last four games.
- The Giants have trailed after 5 innings in four of their last five home games.
Total Runs Facts
- Fifteen of the Giants’ last 17 night games against AL Central opponents have gone UNDER the total runs line.
- Each of the Twins’ last three games as favorites against NL opponents have gone UNDER the total runs line.
- There has been at least one run scored in the first inning in each of the Giants’ last nine night games at Oracle Park.
- There has been at least one run scored in the first inning in each of the Twins’ last six games as favorites against NL opponents.
San Francisco Giants Player Prop Facts
- Drew Gilbert has hit a home run in each of the Giants’ last two games against opponents that held a losing record.
- Anthony Molina has recorded four or more strikeouts in each of his last four appearances.
- Bryce Eldridge has recorded at least one hit in each of his last 14 appearances in night games.
Minnesota Twins Player Prop Facts
- Brooks Lee has hit a home run in four of the Twins’ last five road games against NL opponents.
- Taj Bradley has recorded seven or more strikeouts in each of his last six appearances in night games against teams that held a losing record.
- Josh Bell has recorded at least one hit in each of his last eight appearances with the Twins as road favorites.
- Taj Bradley ranks 9th in the league for total Strikeouts (199) this season.
Matchup/League Facts
- The Giants rank 30th in the league for walks this season (437).
- The Giants rank 28th in the league for on-base percentage this season (.308).
- The Twins rank 26th in the league for runs allowed this season (781).
- The Twins rank 25th in the league for walks this season (493).
Giants vs Twins Prediction
The Twins have the edge with Bradley on the mound given his 3.81 ERA and 1.23 WHIP, but I’m going to grab the plus money with the Giants. We’ve faded the Giants all season, and I’m not thrilled to back Molina and his 4.18 ERA. However, neither of these teams has anything to play for, and I usually want some bang for my buck if forced to pick a side. The Twins have also been terrible on the road this season. Give me the Giants if forced to pick.