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Giants vs Twins Prediction 9/23/26 MLB Picks Today

Minnesota Twins (74-84) vs. San Francisco Giants (65-93)
September 23, 2026 3:45 pm EDT
The Line: San Francisco Giants 123 / Minnesota Twins -149; Over/Under: 7.5
(Get latest betting odds)

The Minnesota Twins and San Francisco Giants meet Wednesday in MLB action at Oracle Park. Here’s a Giants vs. Twins Prediction. This article will include a Giants vs. Twins Pick.

Minnesota Twins Betting Preview

The Minnesota Twins are 74-84 on the year and play the Rangers next. The Minnesota Twins are batting .244 on the season, with a .316 OBP and a .402 slugging percentage. The Minnesota Twins’ pitching staff has a 4.58 ERA and a 1.37 WHIP. Brooks Lee leads the Minnesota Twins with 145 hits and 83 RBI, while Luke Keaschall and Josh Bell have combined for 284 hits and 138 RBI.

Connor Prielipp gets the ball for the Minnesota Twins, and he is 6-7 with a 4.94 ERA and 125 strikeouts this season. This will be Prielipp’s first career game against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 65-93 this year and play the Dodgers next. The San Francisco Giants are batting .247 on the season, have a .309 OBP, and have a .404 slugging percentage. The San Francisco Giants’ pitching staff has a 4.36 ERA and a 1.36 WHIP. Jung Hoo Lee leads the San Francisco Giants with 149 hits and 57 RBI, while Rafael Devers and Willy Adames have combined for 251 hits and 149 RBI.

Cesar Perdomo gets the ball for the San Francisco Giants, and he is 0-1 with a 3.72 ERA and 12 strikeouts this season. This will be Perdomo’s first career game against the Minnesota Twins.

Why the San Francisco Giants will win

  • The Twins have lost each of their last eight road games following a win.
  • The Giants have won four of their last six games as home underdogs against AL Central opponents following a loss.
  • The underdogs have covered the run line in each of the last eight games between the Twins and Giants.
  • The Twins have failed to cover the run line in each of their last eight games as favorites against NL opponents.
  • The Giants have led after 3 innings in each of their last four games against opponents that held a losing record.
  • The Giants have won the first inning in seven of their last nine home games.
  • The Giants have led after 5 innings in eight of their last nine home games against opponents that held a losing record.

Why the Minnesota Twins will win

  • The Giants have lost each of their last eight day games against AL Central opponents that held a losing record.
  • The Twins have won four of their last five games against the Giants.
  • The Giants have failed to cover the run line in each of their last eight day games against AL Central opponents that held a losing record.
  • The Twins have covered the run line in each of their last seven Wednesday games against NL West opponents.
  • The Twins have led after 3 innings in each of their last six Wednesday games against NL West opponents that held a losing record.
  • The Twins have led after 5 innings in each of their last six Wednesday games against NL West opponents that held a losing record.

Total Runs Facts

  • Each of the last four games between the Twins and Giants at Oracle Park have gone UNDER the total runs line.
  • Each of the Twins’ last four games as favorites against NL opponents have gone UNDER the total runs line.
  • There has been at least one run scored in the first inning in nine of Connor Prielipp’s 10 previous road appearances as a starter.
  • There has been at least one run scored in the first inning in eight of the Giants’ last nine home games.

San Francisco Giants Player Prop Facts

  • Drew Gilbert has recorded at least one hit in each of his last nine home appearances against opponents that held a losing record.
  • Drew Gilbert has hit a home run in two of the Giants’ last three games against opponents that held a losing record.
  • Cesar Perdomo has recorded three or more strikeouts in three of his four previous appearances.

Minnesota Twins Player Prop Facts

  • Brooks Lee has hit a home run in three of the Twins’ last four games against NL opponents.
  • Connor Prielipp has recorded six or more strikeouts in each of his last four appearances against NL opponents.
  • Brooks Lee has recorded at least one hit in 17 of his last 18 road appearances after playing the previous day.
  • Connor Prielipp has recorded a win in four of his last five appearances with the Twins as favorites.

Matchup/League Facts

  • The Giants rank 30th in the league for walks this season (443).
  • The Giants rank 29th in the league for on-base percentage this season (.309).
  • The Twins rank 26th in the league for runs allowed this season (783).
  • The Twins rank 25th in the league for walks this season (494).

Giants vs Twins Prediction

The Twins have been terrible on the road this season, and Prielipp has a 4.94 ERA and 1.30 WHIP. Seeing the Twins favored in this spot on the road with this pitcher is nuts. Perdomo has just 19.1 innings under his belt, but he has a 3.72 ERA. The Giants are a team I’ve faded all season, but the plus money at home with the quick turnaround is the spot where I want to be. Give me the Giants.

Randy Chambers's Free Pick: San Francisco Giants 123

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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