Giants vs Yankees Prediction 3/25/26 MLB Picks Today

In this article we will formulate a Giants vs Yankees prediction for this MLB game on Wednesday, March 25th at Oracle Park in San Francisco, California. Let’s take a look at the prediction for this MLB matchup. 

San Francisco Giants Betting Preview

The San Francisco Giants went 81-81 last season, which was third in the NL West standings, and they finished 12 games behind the Dodgers. San Francisco started the 2025 season with a 6-4 win over the Reds on the road. The Giants started last year by winning eight of their first nine games, but they really struggled from the middle of June to the middle of August, which was too much to overcome. San Francisco went 42-39 at home last year and 39-42 on the road, while scoring 705 runs and allowing 684. 

Last season, San Francisco was 10th in the MLB with a 3.82 ERA, along with a 1.30 WHIP and a .248 opponent batting average. The Giants finished 17th in the MLB with 705 runs with a .235 batting average and a .311 on base percentage. Willy Adames led SF with 30 home runs and 87 RBIs, while Matt Chapman added 21 home runs and 61 RBIs. The projected starting pitcher for the Giants is Logan Webb, who went 15-11 with a 3.22 ERA and a 1.24 WHIP over 207.0 innings pitched last season. 

New York Yankees Betting Preview

The New York Yankees were 94-68 last year, which was tied for first in the AL East, but they lost the tie breaker with Toronto. New York started last year with a 4-2 win over the Brewers at home and they ended sweeping that series. The Yankees were up and down for a good part of the season, but they were very good in August and September. New York defeated the Red Sox in the Wild Card round, but lost to the Blue Jays in the ALDS. The Yankees went 50-31 at home and 44-37 on the road last year, while scoring 849 runs and allowing 685. 

Last year, New York had a 3.91 ERA with a 1.25 WHIP and a .229 opponent batting average, while scoring 849 runs with a .251 batting average and a .332 on base percentage. Aaron Judge led the team with 53 home runs and 114 RBIs, while Trent Grisham added 34 home runs and 74 RBIs. The projected starting pitcher for New York is Max Fried, who went 19-5 with a 2.86 ERA and a 1.10 WHIP over 195.1 innings pitched last year. 

Why the San Francisco Giants will win

• The Yankees have lost three of their last four road openers as favorites.
• The Giants have won four of their last six games as home underdogs.
• The Yankees have failed to cover the run line in five of their last six games as favorites against NL West opponents.
• The Giants have covered the run line in four of their last five games against American League opponents.
• The Giants have led after 3 innings in four of their last five games.
• The Giants have won the first inning in each of their last three games against American League opponents.
• The Giants have led after 5 innings in each of their last five games.

Why the New York Yankees will win

• The Yankees have won each of their last six games against National League opponents.
• The Giants have lost four of their last five night games against AL East opponents.
• The Giants have failed to cover the run line in seven of their last eight home openers.
• The Yankees have covered the run line in each of their last five games against National League opponents.
• The Yankees have won the first inning in four of their last five games against the Giants.
• The Yankees have led after 5 innings in nine of their last 10 night games.
• The Yankees have led after 3 innings in six of their last seven season openers as favorites.

Total Runs Facts

• Each of the last six games between the Yankees and Giants have gone OVER the total runs line.
• Each of the Yankees’ last five games as favorites against the Giants have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Yankees’ last six games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last five games between the Yankees and Giants.

San Francisco Giants Player Prop Facts

• Heliot Ramos has hit a home run in three of the Giants’ last four night games.
• Willy Adames has recorded a Double in three of his last four appearances in home openers against AL opponents.
• Rafael Devers has recorded a hit in each of the Giants’ last eight games.
• Logan Webb has recorded a win in four of his last five appearances with the Giants as underdogs.
• Luis Arraez ranked T2nd in the league in Hits (181) last season.

New York Yankees Player Prop Facts

• Ryan McMahon has recorded a Double in each of his last four appearances in season openers.
• Aaron Judge has hit at least one home run in four of the Yankees’ last five games as favorites against NL West opponents.
• Max Fried has recorded six or more strikeouts in seven of his last eight appearances in night games.
• Giancarlo Stanton has recorded at least one hit in each of his last 11 appearances against the Giants.
• Max Fried has recorded a win in six of his last seven appearances with his team as a road favorite against NL opponents .
• Jose Caballero ranked 1st in the league in Steals (49) last season.

Matchup/League Facts

• The Giants ranked 1st in the league for home runs allowed last season (143).
• The Giants ranked 29th in the league for steals last season (68).
• The Yankees ranked 1st in the league for runs scored last season (849).
• The Yankees ranked 1st in the league for home runs last season (274).

Giants vs Yankees Prediction 

New York comes into this matchup after a disappointing end to their 2025 season, but they return another very talented team this year. San Francisco ended up third in the NL West last season and they were not good enough offensively. The Giants do have a solid pitching staff once again this year, but we are getting the better lineup and Max Fried at a great price. Take the Yankees to get the win here.