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Guardians vs Angels Prediction 5/12/26 MLB Picks Today

LA Angels (16-26) vs. Cleveland Guardians (22-21)
May 12, 2026 6:10 pm EDT
The Line: Cleveland Guardians -136 / LA Angels 113; Over/Under: 8.5
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In this article we will formulate a Guardians vs Angels prediction for this MLB game on Tuesday, May 12th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 22-21 this year after they won game one by a score of 7-2 on Monday night. Cleveland scored the first seven runs in the game and they cruised to the easy win. The Guardians recorded seven hits in the game and they were led by Rocchio, who went 1-4 with two RBIs. Cantillo allowed five hits and zero earned runs over 6.0 innings for the win, while Pallette allowed one earned run in relief. Prior to this series, Cleveland lost two out of three against the Twins and split four games with the Royals. 

This season, Cleveland has a 3.89 ERA with a 1.28 WHIP and a .238 opponent batting average, while they have scored 180 runs with a .229 batting average and a .323 on base percentage. Chase DeLauter has led the Guardians with six home runs and 25 RBIs, while Jose Ramirez has added six home runs and 16 RBIs. The projected starting pitcher for Cleveland is Slade Cecconi, who is 2-4 with a 6.15 ERA and a 1.59 WHIP over 41.0 innings pitched this year. 

Los Angeles Angels Betting Preview

The Los Angeles Angels are 16-26 this season after they lost game one by a score of 7-2 last night. Los Angeles managed to out hit Cleveland in the game, but they only scored in the eighth and ninth inning for the lopsided loss. The Angels recorded nine hits in the game and they were led by Adell, who went 2-4 with one RBI. Suter allowed two earned runs and two hits over 1.2 innings for the loss, while Fermin allowed three earned runs in relief. Prior to this series, Los Angeles lost two out of three against the Blue Jays, but did win two out of three against the White Sox before that. 

This season, Los Angeles has a 4.63 ERA with a 1.45 WHIP and a .243 opponent batting average, while they have scored 179 runs with a .233 batting average and a .321 on base percentage. Jorge Soler has led the Angels with eight home runs and 28 RBIs, while Mike Trout has added 11 home runs and 23 RBIs. The projected starting pitcher for Los Angeles is Walbert Urena, who is 1-3 with a 3.22 ERA and a 1.57 WHIP over 22.1 innings pitched this season. 

Why the Cleveland Guardians will win

  • The Angels have lost each of their last 10 games at Progressive Field following a road loss.
  • The Guardians have won 18 of their last 19 games against the Angels at Progressive Field following a home win.
  • The Guardians have covered the run line in eight of their last nine night games against the Angels at Progressive Field following a home win.
  • The Angels have failed to cover the run line in six of their last seven road games against AL Central opponents.
  • The Angels have trailed after 3 innings in six of their last seven road games against AL Central opponents that held a winning record.
  • The Angels have trailed after 5 innings in five of their last six road night games.

Why the Los Angeles Angels will win

  • The Guardians have lost six of their last seven games as home favorites following a home win.
  • The Angels have won three of their last four games as underdogs following a loss.
  • The Angels have covered the run line each of their last eight night games against AL Central opponents that held a winning record.
  • The Guardians have failed to cover the run line in eight of their last nine games as home favorites following a home win.
  • The Angels have led after 3 innings in six of their last eight games at Progressive Field against opponents that held a winning record.
  • The Guardians have trailed after 5 innings in seven of their last eight games against AL West opponents that held a losing record.

Total Runs Facts

  • Seven of the Angels’ last eight games as underdogs against AL Central opponents have gone OVER the total runs line.
  • Each of the Guardians’ last five night games against AL West opponents have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Angels’ last eight games at Progressive Field.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of Slade Cecconi’s last five appearances as a starter.

Cleveland Guardians Player Prop Facts

  • Jose Ramirez has hit a home run in two of the Guardians’ last three games against the Angels.
  • Patrick Bailey has recorded at least one hit in each of his last six Tuesday appearances with his team as a favorite.

Los Angeles Angels Player Prop Facts

  • Mike Trout has hit at least one home run in each of the Angels’ last five games against AL opponents that held a winning record.
  • Zach Neto has recorded at least one hit in each of the Angels’ last eight games as underdogs against AL opponents.

Guardians vs Angels Prediction 

Cleveland was able to get the win to start this series on Monday night and they have scored 6+ runs in three of their last five games. The Guardians are 11-9 at home this year, while the Angels are 8-16 on the road. Los Angeles has dropped three of their last four games and they have allowed 21 runs in their last two losses. The Angels are starting Urena, who has allowed two earned runs or fewer in three of his last four starts, while Cecconi has allowed 4+ earned runs in three of his last four starts. I don’t like how Cecconi has looked recently, so I will take the Angels here. 

David Racey's Free Pick: Angels ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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