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Guardians vs Angels Prediction 5/31/25 MLB Picks Today

LA Angels (26-30) vs. Cleveland Guardians (30-26)
May 31, 2025 4:10 pm EDT
The Line: Cleveland Guardians -185 / LA Angels 154; Over/Under: 8
(Get latest betting odds)

The Los Angeles Angels and Cleveland Guardians meet Saturday in MLB action at Progressive Field. Here’s a Guardians vs Angels Prediction. This article will include a Guardians vs Angels Pick.

Los Angeles Angels Betting Preview

The Los Angeles Angels are 26-30 on the year and play the Red Sox, Mariners, and Athletics next. The Los Angeles Angels are batting .227 on the season, have a .287 OBP, and a .405 slugging percentage. The Los Angeles Angels pitching staff has a 4.77 ERA and a 1.51 WHIP. Nolan Schanuel leads the Los Angeles Angels with 52 hits and 14 RBI, while Taylor Ward and Logan O’Hoppe have combined for 93 hits and 67 RBI.

Kyle Hendricks gets the ball for the Los Angeles Angels, and he is 2-6 with a 5.23 ERA and 33 strikeouts this season. Hendricks is 2-0 with a 0.75 ERA and 10 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 30-26 on the year and play the Yankees, Astros, and Reds next. The Cleveland Guardians are batting .233 on the season, have a .306 OBP, and a .376 slugging percentage. The Cleveland Guardians pitching staff has a 4.12 ERA and a 1.40 WHIP. Steven Kwan leads the Cleveland Guardians with 67 hits and 19 RBI while Jose Ramirez and Carlos Santana have combined for 111 hits and 55 RBI.

Slade Cecconi gets the ball for the Cleveland Guardians, and he is 1-1 with a 3.27 ERA and 14 strikeouts this season. This will be Cecconi’s second career game against the Los Angeles Angels.

Why the Cleveland Guardians will win

  • The Angels have lost each of their last six games at Progressive Field following a win.
  • The Guardians have won each of their last four day games against AL West opponents that held a losing record.
  • The Angels have failed to cover the run line in each of their last eight games against AL Central opponents following a road win.
  • The Guardians have covered the run line in each of their last eight Saturday day games against American League opponents.
  • The Angels have lost the first inning in three of their last four road games against AL Central opponents.
  • The Guardians have led after 3 innings in eight of their last nine day games against American League opponents that held a losing record.
  • The Guardians have led after 5 innings in seven of their last eight day games at Progressive Field against AL West opponents.

Why the Los Angeles Angels will win

  • The Angels have won each of their last eight games as road underdogs.
  • The Guardians have lost each of their last four games as favorites.
  • The Angels have covered the run line in each of their last eight road games.
  • The Guardians have failed to cover the run line each of their last five games against teams that held a losing record.
  • The Angels have led after 3 innings in each of their last four road games against opponents that held a winning record.
  • The Guardians have trailed after 5 innings in each of their last six games.

Cleveland Guardians Player Prop Facts

  • Carlos Santana has scored a run in each of his last six appearances against the Angels at Progressive Field.
  • Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
  • Jose Ramirez has recorded at least one hit in each of his last 18 appearances after playing the previous day.
  • Carlos Santana has recorded an RBI in each of his last four appearances in day games.
  • Steven Kwan has recorded at least one Single in each of his last nine appearances against AL opponents.
  • Jose Ramirez has hit a home run in three of the Guardians’ last five games as favorites.

Los Angeles Angels Player Prop Facts

  • Jorge Soler has hit a home run in each of the Angels’ last three games against the Guardians.
  • Zach Neto has recorded at least one RBI in each of his last five appearances in day games against teams that held a winning record.
  • Jorge Soler has scored at least one run in eight of his last nine appearances at Progressive Field against opponents that held a winning record.
  • Logan O’Hoppe has recorded at least one Single in each of the Angels’ last seven games against the Guardians.
  • Kyle Hendricks has recorded four or more strikeouts in seven of his last eight road appearances against AL Central opponents.
  • Zach Neto has recorded at least one hit in each of his last 12 road appearances against AL opponents.
  • Travis d’Arnaud has recorded a Double in three of his last four appearances against AL Central opponents.
  • Taylor Ward ranks T6th in the league in Home Runs (15) this season.

Guardians vs Angels Prediction

The Angels just aren’t a team I’m willing to back most nights, as they’re not a good team, and it doesn’t help that Hendricks has fallen off like Big Mac toppings. Hendricks has a 5.23 ERA and 1.26 WHIP on the season. Hendricks has allowed 31 hits and 14 runs in his last 30.1 innings. In 29.2 road innings, Hendricks has a 6.37 ERA and .265 allowed batting average. The Guardians are due for a feel good win to bounce back, and Cecconi has been respectable through 11 innings, allowing 10 hits and four runs. Give me the Guardians and the RL for max betting value.

Randy Chambers's Free Pick: Cleveland Guardians -1.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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