Guardians vs Astros Prediction 4/20/26 MLB Picks Today

In this article we will formulate a Guardians vs Astros prediction for this MLB game on Monday, April 20th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 13-10 this season after they won three out of four against the Orioles by scores of 4-2, 4-6, 4-2, and 8-4. In game four, Cleveland scored the first five runs in the game and they added two in the fifth and two in the eighth to seal the win. The Guardians recorded eight hits and they committed one error in the game, while they were led by Rocchio, who went 3-4 with three RBIs. Cantillo allowed five hits and three earned runs over 4.2 innings, while Festa got the win in relief. Prior to that series, Cleveland lost two out of three against the Cardinals and two out of three against the Braves. 

This season, Cleveland has a 3.91 ERA with a 1.25 WHIP and a .223 opponent batting average, while they have scored 95 runs with a .226 batting average and a .312 on base percentage. Brayan Rocchio has led the Guardians with three home runs and 14 RBIs, while Jose Ramirez has added six home runs and 12 RBIs. The projected starting pitcher for Cleveland is Slade Cecconi, who is 0-2 with a 5.03 ERA and a 1.37 WHIP over 19.2 innings pitched this season. 

Houston Astros Betting Preview

The Houston Astros are 8-15 this year after they lost all three against the Cardinals by scores of 4-9, 5-7, and 5-7. In game three, Houston led 1-0 in the third inning, but they needed three in the eighth to tie it up, before losing in extra innings. The Astros recorded eight hits and they committed one error in the game, while they were led by Paredes, who went 1-4 with two RBIs. Burrows allowed three hits and four earned runs over 4.2 innings, while King picked up the loss in extras. Prior to that series, Houston won two out of three against the Rockies, but lost all four against the Mariners before that. 

This season, Houston has a 6.11 ERA with a 1.63 WHIP and a .263 opponent batting average, while they have scored 121 runs with a .255 batting average and a .348 on base percentage. Yordan Alvarez has led the Astros with 10 home runs and 21 RBIs, while Christian Walker has added four home runs and 16 RBIs. The projected starting pitcher for Houston is Spencer Arrighetti, who is 1-0 with a 1.50 ERA and a 1.17 WHIP over 6.0 innings pitched this year. 

Why the Cleveland Guardians will win

• The Astros have lost each of their last eight road games.
• The Guardians have won each of their last four games against the Astros.
• The Astros have failed to cover the run line in seven of their last eight games.
• The Guardians have covered the run line in each of their last four games against the Astros.
• The Astros have lost the first inning in each of their last five road games.
• The Astros have trailed after 3 innings in each of their last seven night games against opponents that held a winning record.
• The Astros have trailed after 5 innings in each of their last seven night games against opponents that held a winning record.

Why the Houston Astros will win

• The Guardians have lost each of their last eight night games following a win.
• The underdogs have won each of the Astros’ last four games.
• The Guardians have failed to cover the run line in each of their last eight night games following a win.
• The Astros have covered the run line in each of their last six night games at Progressive Field following a loss.
• The Astros have led after 3 innings in eight of their last 10 night games against the Guardians at Progressive Field.
• The Astros have led after 5 innings in 11 of their last 12 night games against the Guardians at Progressive Field.

Total Runs Facts

• Each of the Astros’ last six night games against American League opponents have gone OVER the total runs line.
• Each of the Guardians’ last four games as favorites against the Astros have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last eight games as underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Guardians’ last seven games as home favorites.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in four of the Guardians’ last five games against the Astros.
• Brayan Rocchio has recorded at least one hit in each of his last 10 appearances with the Guardians as favorites.
• Jose Ramirez ranks 1st in the league in Steals (10) this season.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit a home run in four of the Astros’ last five games.
• Jose Altuve has recorded two or more hits in each of his last six appearances with the Astros as underdogs against the Guardians.
• Yordan Alvarez ranks 1st in the league in Home Runs (10) this season.

Matchup/League Facts

• The Guardians rank 1st in the league for strikeouts this season (229).
• The Guardians rank T29th in the league for triples this season (0).
• The Astros rank 1st in the league for doubles this season (53).
• The Astros rank 30th in the league for ERA this season (6.11).

Guardians vs Astros Prediction 

Houston comes into this matchup on a four game losing streak and they have allowed 23 runs in their last three games. The Astros are 1-9 on the road this year, while the Guardians are 7-3 at home. Cleveland is coming off of a series win against Baltimore and they are starting Cecconi, who has allowed 1, 4, 0, and 6 earned runs in his four outings. The Astros are turning to Arrighetti, who allowed three hits and one earned run over 6.0 innings against Colorado in his first start. Houston continues to play in very high scoring games, as their pitching has been terrible, so I will back the over once again here.