Guardians vs Astros Prediction 4/22/26 MLB Picks Today

In this article we will formulate a Guardians vs Astros prediction for this MLB game on Wednesday, April 22nd at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 14-11 this year after they split the first two games in this series by scores of 2-9 and 8-5. In game two, Cleveland trailed 4-2 in the eighth inning, but they scored six runs in the eighth for the win. The Guardians recorded 11 hits and they committed one error in the game, while they were led by DeLauter, who went 1-4 with three RBIs. Messick allowed six hits and three earned runs over 5.0 innings, while Pallette got the win in relief. Prior to this series, Cleveland won three out of four against the Orioles, but lost two out of three against the Cardinals before that. 

This season, Cleveland has a 4.08 ERA with a 1.28 WHIP and a .231 opponent batting average, while they have scored 105 runs with a .231 batting average and a .321 on base percentage. Brayan Rocchio has led the Guardians with three home runs and 15 RBIs, while Jose Ramirez has added six home runs and 12 RBIs. The projected starting pitcher for Cleveland is Tanner Bibee, who is 0-2 with a 4.81 ERA and a 1.52 WHIP over 24.1 innings pitched this year. 

Houston Astros Betting Preview

The Houston Astros are 9-16 this season after they lost game two by a score of 8-5 on Tuesday. Houston trailed 2-0 in the middle innings, but they rallied to lead 4-2, before blowing the lead in the eighth for the loss. The Astros recorded 10 hits in the game and they were led by Alvarez, who went 2-5 with three RBIs. Weiss allowed five hits and two earned runs over 3.1 innings, while De Los Santos and King both allowed three earned runs in relief. Prior to this series, Houston lost all three against the Cardinals, but did win two out of three against the Rockies before that. 

This season, Houston has a 6.05 ERA with a 1.65 WHIP and a .265 opponent batting average, while they have scored 135 runs with a .262 batting average and a .352 on base percentage. Yordan Alvarez has led the Astros with 10 home runs and 24 RBIs, while Christian Walker has added five home runs and 18 RBIs. The projected starting pitcher for Houston is Peter Lambert, who is 0-1 with a 7.20 ERA and a 1.60 WHIP over 5.0 innings pitched this season. 

Why the Cleveland Guardians will win

• The Astros have lost each of their last seven road games following a road loss.
• The Guardians have won each of their last eight Wednesday games against AL West opponents that held a losing record.
• The Astros have failed to cover the run line in seven of their last eight games following a road loss.
• The Guardians have covered the run line in each of their last seven Wednesday games against American League opponents.
• The Astros have lost the first inning in six of their last seven road games.
• The Astros have trailed after 5 innings in each of their last five day games.
• The Guardians have led after 3 innings in five of their last six home games against AL West opponents that held a losing record.

Why the Houston Astros will win

• The underdogs have won five of the Astros’ last six games.
• The Guardians have lost five of their last six games as favorites following a win.
• The Astros have covered the run line in each of their last six games as underdogs against AL Central opponents following a road loss.
• The Guardians have failed to cover the run line in seven of their last eight games as favorites following a win.
• The Guardians have trailed after 5 innings in each of their last six games against AL West opponents that held a losing record.

Total Runs Facts

• Thirteen of the Astros’ last 14 games against American League opponents have gone OVER the total runs line.
• Each of the Guardians’ last four games against AL West opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last 10 games as underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last 10 day games between the Astros and Guardians.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in three of the Guardians’ last five games against the Astros.
• Brayan Rocchio has recorded at least one hit in each of his last 12 appearances with the Guardians as favorites.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit a home run in three of the Astros’ last five games.
• Isaac Paredes has recorded at least one hit in each of his last 10 appearances against AL opponents.

Guardians vs Astros Prediction 

Cleveland comes into this matchup after winning three of their last four games and they have scored eight runs in two of their last three. The Guardians are 8-4 at home this year, while the Astros are 2-10 on the road. Houston continues to have massive issues with their pitching staff and their team ERA is north of six at the moment. I don’t trust either starter in this contest, but I will not back Houston right now. Take Cleveland to win at home.