Guardians vs Blue Jays Prediction 4/24/26 MLB Picks Today

In this article, we will formulate a Guardians vs Blue Jays Prediction for this MLB matchup on Friday, April 25^th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Toronto Blue Jays Preview

The Toronto Blue Jays have a 10-14 record this season and are sitting in the fourth place of the AL East. They have a 6-6 home record and are coming off a 3-7 road loss against the Angels. Their previous three games were a 4-2 and a 5-2 road win against the Angels, and a 10-4 road win against the Diamondbacks.

The Blue Jays have a .256 batting average this season, .317 OBP and .379 Slugging percentage. Toronto’s pitching staff has a 4.46 ERA and 1.32 WHIP. Vladimir Guerrero Jr. is the team’s best hitter with a .337 batting average, also leading the team in RBI with 12. Andres Gimenez adds a team‑high 3 home runs.

Max Scherzer (R) is the projected starting pitcher for the Blue Jays, and he has a 1-2 record, 7.16 ERA and 1.29 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 14-12 record this season and are sitting in the first place of the AL Central. They have a 6-7 away record and are coming off a 0-2 home loss against the Astros. Their previous three games were an 8-5 home win and a 2-9 home loss against the Astros, and an 8-4 home win against the Orioles.

The Guardians have a .228 batting average this season, .318 OBP and .374 Slugging percentage. Cleveland’s pitching staff has a 4.00 ERA and 1.26 WHIP. Brayan Rocchio is the team’s best hitter with a .269 batting average, also leading the team in RBI with 15. Jose Ramirez adds a team‑high 6 home runs.

Gavin Williams (R) is the projected starting pitcher for the Guardians, and he has a 3-1 record, 2.12 ERA and 1.01 WHIP.

Cleveland Guardians @ Toronto Blue Jays Betting Trends: April 24, 2026

• Probable Starting Pitcher: Max Scherzer      Record this season: 1-2      ERA: 7.16
• Home Record: 1-2
• Last 5 against Guardians: 0-1

Why the Toronto Blue Jays will win

• The Blue Jays have won each of their last eight night games against American League opponents.
• The Guardians have lost each of their last three games as road favorites following a home loss.
• The Blue Jays have covered the run line each of their last 10 night games against AL Central opponents that held a winning record.
• The Guardians have failed to cover the run line in each of their last six games as road favorites following a home loss.
• The Guardians have trailed after 3 innings in four of their last five games at Rogers Centre.
• The Blue Jays have won the first inning in three of their last four home games against American League opponents.
• The Guardians have trailed after 5 innings in four of their last five games at Rogers Centre.

• Probable Starting Pitcher: Gavin Williams      Record this season: 3-1      ERA: 2.12
• Road Record: 2-1
• Last 5 against Blue Jays: 0-0

Why the Cleveland Guardians will win

• The Guardians have won each of their last 10 night games following a loss.
• The Blue Jays have lost five of their last six games against AL Central opponents.
• The Guardians have covered the run line in each of their last nine night games following a loss.
• The Blue Jays have failed to cover the run line in seven of their last eight games against AL Central opponents following a loss.
• The Blue Jays have trailed after 3 innings in each of their last six games against AL Central opponents.
• The Blue Jays have lost the first inning in three of their last four night games against AL Central opponents.
• The Blue Jays have trailed after 5 innings in nine of their last 10 games as home underdogs against AL Central opponents.

Total Runs Facts

• Each of the Blue Jays’ last seven home games against AL Central opponents have gone OVER the total runs line.
• Three of the Guardians’ last four games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Blue Jays’ last six games against AL Central opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Guardians’ last eight games as road favorites.

Toronto Blue Jays Player Prop Facts

• Max Scherzer has recorded a win in four of his last five home appearances against AL Central opponents.
• Max Scherzer has recorded five or more strikeouts in four of his last five appearances with his team as a home underdog against AL opponents.
• George Springer has hit a home run in three of his last four home appearances against the Guardians after not playing the previous day.
• George Springer has recorded at least one hit in each of his last 11 appearances against AL Central opponents that held a winning record.
• Ernie Clement ranks T3rd in the league in Hits (32) this season.

Cleveland Guardians Player Prop Facts

• Steven Kwan has recorded two or more hits in each of the Guardians’ last five road games against the Blue Jays.
• Austin Hedges has hit a home run in each of his two previous appearances with his team as a road favorite against the Blue Jays.
• Jose Ramirez ranks 1st in the league in Steals (11) this season.

Matchup/League Facts

• The Blue Jays rank 1st in the league for strikeouts against this season (165).
• The Blue Jays rank T28th in the league for steals this season (8).
• The Guardians rank 2nd in the league for strikeouts this season (244).
• The Guardians rank T24th in the league for triples this season (1).

Guardians vs Blue Jays Prediction

The Guardians are 6-3 in their last 9 meetings against the Blue Jays and are 2-1 in their last three visits in Toronto.

In this Guardians vs Blue Jays Prediction, the Guardians are coming as -130 road favorites. Max Scherzer takes the mound for the Jays and he has been struggling this season and both teams have bottom-8 bullpen ERA’s this season so the total of 7.5 feels too low. Both teams average 8.1 runs per game combined and the Guardians are 3-1 to the over in their last 4 games. Take the over 7.5 in this one.