Guardians vs Rays Prediction 9/4/25 MLB Picks Today

In this article, we will formulate a Guardians vs Rays Prediction for this MLB game on Thursday, September 4^th at the George M. Steinbrenner Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Tampa Bay Rays Preview

The Tampa Bay Rays have a 70-69 record this season and are sitting on the 4^th place of the AL East. The Rays have a 37-33 home record and are 60-70 in over/under. They are coming off a 9-4 home victory over the Mariners, and have six consecutive wins. Over is 4-0 in their last 4 games and are playing the Cubs and the White Sox next.

The Rays have a .253 batting average this season, .314 OBP and .404 slugging percentage. Tampa’s pitching staff has a 3.89 ERA and 1.21 WHIP.  Yandy Diaz leads the Rays with 151 hits, and he is the team’s best hitter with .294 batting average. Junior Caminero leads the team in RBI, with 102 and in home runs, with 40.

Ryan Pepiot (R) is the projected starting pitcher for the Rays, and he has a 10-10 record, 3.70 ERA and 1.15 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 69-69 record this season and are sitting on the third place of the AL Central. The Guardians have a 34-36 road record and are 65-68 in over/under. They are coming off an 8-1 road victory over the Red Sox, which ended their three-game losing streak. Over is 3-0 in their last 3 games and are playing the Royals and the White Sox next.

The Guardians have a .224 batting average this season, .294 OBP and .369 Slugging percentage. Cleveland’s pitching staff has a 3.97 ERA and 1.32 WHIP. Stephen Kwan leads the Guardians with 136 hits, while Jose Ramirez is the team’s best hitter with a .278 batting average. He also leads the team both in RBI, with 70, and in home runs with 26.

Logan Allen (L) is the projected starting pitcher for the Guardians, and he has a 7-10 record, 4.42 ERA and 1.44 WHIP.

Guardians vs Rays Prediction

The Guardians are 4-1 in their last 5 meetings against the Rays, but the Rays are 2-1 in their last 3 meetings in Tampa. Under is 8-1-1 in their last 10 meetings.

In this Guardians vs Rays Prediction, the Rays are coming as -150 home favorites. Rays have the pitching advantage with Pepiot on the mound, who has been better than Logan Allen this season, and even more effective at home, with a 3.25 home ERA. He is also in excellent form lately, coming off back-to-back shutout starts. On the flip side, Allen has been weaker on the road for the Guardians, with a 4.97 road ERA, and has been torched in his last two starts, with 13 earned runs in 11 innings pitched. The Rays are red-hot right now, and I expect them to keep rolling and extend their winning streak at home in this one.