Guardians vs Tigers Prediction 9/24/25 MLB Picks Today

In this article we will formulate a Guardians vs Tigers prediction for this MLB game on Wednesday, September 24th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 85-72 this season after they won game one by a score of 5-2 on Tuesday night. Cleveland trailed 2-0 in the sixth inning, but scored three runs in the inning and added two more in the seventh to seal the win. The Guardians recorded seven hits in the game and they were led by Schneemann, who went 1-1 with two RBIs in the win. Cleveland started Williams, who allowed four hits and two earned runs over 6.0 innings for the win, while Smith picked up the save. 

Prior to this series, the Guardians won three out of four against the Twins and all three against the Tigers. Cleveland has won 11 of their last 12 games and they are now first in the AL Central standings. The Cleveland pitching staff has a 3.69 ERA with a 1.27 WHIP and a .239 opponent batting average, while the offense has scored 621 runs with a .226 batting average and a .297 on base percentage this season. Jose Ramirez has led Cleveland with 30 home runs and 82 RBIs, while Kyle Manzardo has added 26 home runs and 68 RBIs this year. The projected starting pitcher for Cleveland is Tanner Bibee, who is 11-11 with a 4.34 ERA and a 1.23 WHIP over 176.1 innings pitched this season. 

Detroit Tigers Betting Preview

The Detroit Tigers are 85-72 this year after they dropped game one by a score of 5-2 last night. Detroit led 2-0 in the sixth inning, but they fell apart and picked up yet another loss. The Tigers recorded five hits and they committed one error in the game, while they were led by Greene and Perez, who both had one RBI in the loss. Detroit started Skubal, who allowed four hits and one earned run over 6.0 innings for the loss, while Kahnle and Finnegan allowed one earned run in relief. 

Prior to this series, the Tigers lost all three against the Braves and all three against the Guardians. Detroit has lost 10 of their last 11 games and they are second in the AL Central standings. The Detroit pitching staff has a 3.98 ERA with a 1.25 WHIP and a .242 opponent batting average, while the offense has scored 745 runs with a .247 batting average and a .316 on base percentage this season. Riley Greene has led Detroit with 35 home runs and 110 RBIs, while Spencer Torkelson has added 31 home runs and 78 RBIs this year. The projected starting pitcher for Detroit is Jack Flaherty, who is 8-14 with a 4.60 ERA and a 1.28 WHIP over 156.2 innings pitched this year. 

Why the Guardians will beat the Tigers

• The Guardians have won each of their last eight night games against AL Central opponents.
• The Tigers have lost each of their last seven games.
• The Guardians have covered the run line in each of their last 11 night games against AL Central opponents following a win.
• The Tigers have failed to cover the run line in each of their last seven games.
• The Tigers have lost the first inning in three of their last four games as road underdogs.
• The Guardians have led after 3 innings in 10 of their last 11 Wednesday games against opponents that held a winning record.
• The Guardians have led after 5 innings in 13 of their last 15 night games against AL Central opponents.

Total Runs Facts

• Each of the Guardians’ last six home games after playing the previous day have gone UNDER the total runs line.
• Each of the Tigers’ last four road games against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last six games between the Tigers and Guardians.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last four games against AL Central opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit at least one home run in three of the Guardians’ last five games as favorites against the Tigers.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last 10 Wednesday games.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Jose Ramirez ranks 3rd in the league in Steals (40) this season.

Detroit Tigers Player Prop Facts

• Riley Greene has hit a home run in each of the Tigers’ last two road games against the Guardians.
• Jack Flaherty has recorded six or more strikeouts in each of his last four appearances with the Tigers as underdogs.
• Jake Rogers has recorded a Double in three of his last four appearances against AL Central opponents.
• Javier Baez has recorded at least one hit in each of his last 11 appearances with the Tigers as underdogs against AL opponents.
• Riley Greene ranks T10th in the league in Home Runs (35) this season.

Matchup/League Facts

• The Guardians rank 30th in the league for hits this season (1164).
• The Guardians rank 29th in the league for batting average this season (.226).
• The Tigers rank 30th in the league for steals this season (60).
• The Tigers rank T2nd in the league for triples this season (36).

Guardians vs Tigers Prediction 

Cleveland was able to work some magic to get the win in game one of this series and they have reclaimed the AL Central lead. The Guardians are 42-34 at home this year, while the Tigers are 39-37 on the road. Detroit is in the middle of a generational collapse and they are starting Flaherty, who has allowed one earned run or fewer in three of his last four starts. Cleveland is starting Bibee, who has allowed two earned runs or fewer in three straight. This should be another very tightly contested game, but I don’t see how we can take the Tigers right now. Take Cleveland to win.