Guardians vs Twins Prediction 9/13/26 MLB Picks Today

In this article, we will formulate a Guardians vs Twins Prediction for this MLB matchup on Sunday, September 13^th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 70-78 record this season and are sitting in the 3rd place of the AL Central. They have a 39-35 home record and are coming off a 4-3 home win against the Guardians. They will face the Yankees and the Angels next.

The Minnesota Twins have a .244 batting average this season, .319 OBP and .405 Slugging percentage. Minnesota’s pitching staff has a 4.66 ERA and 1.37 WHIP. Luke Keaschall is the team’s best hitter with a .271 batting average. Josh Bell leads the team in RBI with 86, while Kody Clemens adds a team-high 26 home runs.

Joe Ryan (R) is the projected starting pitcher for the Twins, and he has a 6-9 record, 3.68 ERA and 1.13 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 75-74 record this season and are sitting in the 2nd place of the AL Central. They have a 39-35 away record and are coming off a 3-4 road loss against the Twins. They will face the White Sox and the Athletics next.

The Cleveland Guardians have a .236 batting average this season, .314 OBP and .371 Slugging percentage. Cleveland’s pitching staff has a 3.80 ERA and 1.26 WHIP. Chase DeLauter is the team’s best hitter with a .291 batting average. Brayan Rocchio leads the team in RBI with 65, while Angel Martinez adds a team-high 15 home runs.

Tanner Bibee (R) is the projected starting pitcher for the Guardians, and he has a 5-15 record, 4.22 ERA and 1.20 WHIP.

Cleveland Guardians @ Minnesota Twins Betting Trends: September 13, 2026

• Probable Starting Pitcher: Joe Ryan      Record this season: 6-9      ERA: 3.68
• Home Record: 3-4
• Last 5 against Guardians: 0-2

Why the Minnesota Twins will win

• The Guardians have lost each of their last eight Sunday road games against AL opponents.
• The Twins have won four of their last five home games after playing the previous day.
• The Twins have covered the run line in each of their last nine Sunday day games against AL opponents.
• The Guardians have failed to cover the run line in 13 of their last 14 Sunday games against AL Central opponents.
• The Twins have led after 5 innings in each of their last six Sunday home games.
• The Guardians have trailed after 3 innings in each of their last six games against AL Central opponents.

• Probable Starting Pitcher: Tanner Bibee       Record this season: 5-15      ERA: 4.22
• Road Record: 3-6
• Last 5 against Twins: 1-0

Why the Cleveland Guardians will win

• The Twins have lost five of their last six games as favorites against the Guardians following a win.
• The Guardians have won 13 of their last 17 games as underdogs against the Twins.
• The Guardians have covered the run line in each of their last 12 games as underdogs against the Twins.
• The Twins have failed to cover the run line in 12 of their last 13 games as home favorites against the Guardians following a win.
• The Guardians have led after 3 innings in three of their last four day games against the Twins at Target Field.

Total Runs Facts

• Seven of the last eight games between the Guardians and Twins at Target Field have gone UNDER the total runs line.
• Each of the Guardians’ last five games against AL Central opponents have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in seven of the Twins’ last eight day games against AL opponents.
• There has been no run scored during the first inning in each of the Guardians’ last five games at Target Field.

Minnesota Twins Player Prop Facts

• Brooks Lee has hit a home run in four of the Twins’ last five Sunday games.
• Ryan Jeffers has recorded a hit in each of his last 10 appearances against the Guardians.
• Joe Ryan has recorded four or more strikeouts in each of his last 34 appearances with the Twins as home favorites.

Cleveland Guardians Player Prop Facts

• Tanner Bibee has recorded four or more strikeouts in each of his 11 previous appearances against the Twins.
• Steven Kwan has recorded at least one hit in each of his last 11 appearances with the Guardians as road underdogs.
• Tanner Bibee has recorded a win in each of his last three appearances with the Guardians as underdogs against the Twins.
• Patrick Bailey has hit a home run in three of his last four appearances against the Twins.

Matchup/League Facts

• The Twins are one of only three teams in the league to rank top 10 in both strikeouts and on-base percentage this season.
• The Twins rank 26th in the league for ERA this season (4.66).
• The Guardians rank 30th in the league for home runs this season (139).
• The Guardians rank 30th in the league for slugging percentage this season (.371).

Guardians vs Twins Prediction

The Twins are 3-1 in their last 4 meetings against the Guardians but have lost two of their last three meetings in Minnesota.

In this Guardians vs Twins Prediction, the Twins are coming as -130 home favorites. I like the Twins to keep rolling in a must-win game between two teams fighting for a wild card spot in the AL. Joe Ryan has been excellent at home with a 3.44 ERA, while Bibee has been in bad shape, with 5 earned runs in each of his last two starts and has a 4.36 road ERA. The Twins have a better offense than the Guardians this season and a better against right-handed pitching. Take the Twins in this one.