Guardians vs Twins Prediction 4/28/25 MLB Picks Today

The Minnesota Twins and Cleveland Guardians meet Monday in MLB action at Progressive Field. Here’s a Guardians vs Twins Prediction. This article will include a Guardians vs Twins Pick.

Minnesota Twins Betting Preview

The Minnesota Twins are 12-16 on the year and play the Red Sox, Orioles, and Giants next. The Minnesota Twins are batting .226 on the season, have a .305 OBP, and a .360 slugging percentage. The Minnesota Twins pitching staff has a 3.64 ERA and a 1.21 WHIP. Ty France leads the Minnesota Twins with 23 hits and 15 RBI, while Byron Buxton and Trevor Larnach have combined for 45 hits and 29 RBI.

Bailey Ober gets the ball for the Minnesota Twins, and he is 2-1 with a 5.04 ERA and 23 strikeouts this season. Ober is 2-2 with a 2.20 ERA and 46 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 15-12 on the year and play the Blue Jays, Nationals, and Phillies next. The Cleveland Guardians are batting .237 on the season, have a .308 OBP, and a .386 slugging percentage. The Cleveland Guardians’ pitching staff has a 4.37 ERA and a 1.43 WHIP. Steven Kwan leads the Cleveland Guardians with 37 hits and 15 RBI, while Jose Ramirez and Gabriel Arias have combined for 47 hits and 25 RBI.

Gavin Williams gets the ball for the Cleveland Guardians, and he is 2-1 with a 4.15 ERA and 26 strikeouts this season. Williams is 2-1 with a 2.12 ERA and 14 strikeouts in his career against the Minnesota Twins.

Why the Cleveland Guardians will win

• The Guardians have won each of their last six night games against AL Central opponents that held a losing record.
• The Twins have lost seven of their last eight road games following a win.
• The Twins have failed to cover the run line in each of their last eight Monday games.
• The favorites have covered the run line in six of the Twins’ last seven games.
• The Guardians have led after 3 innings in seven of their last eight games against AL Central opponents that held a losing record.
• The Guardians have won the first inning in three of their last four night games against AL Central opponents that held a losing record.
• The Guardians have led after 5 innings in each of their last four night games against AL Central opponents that held a losing record.

Why the Minnesota Twins will win

• The underdogs have won six of the last seven games between the Twins and Guardians.
• The Guardians have lost three of their last four games.
• The Guardians have failed to cover the run line in each of their last nine night games against the Twins at Progressive Field following a loss.
• The underdogs have covered the run line in each of the last seven games between the Twins and Guardians.
• The Guardians have lost the first inning in four of their last five night games.
• The Twins have led after 5 innings in each of their last six night games against AL Central opponents that held a winning record.
• The Twins have led after 3 innings in each of their last four night games against American League opponents.

Cleveland Guardians Player Prop Facts

• Steven Kwan has hit a home run in five of the Guardians’ last 12 games against opponents that held a losing record.
• Carlos Santana has recorded an RBI in each of his last four appearances with the Guardians as home favorites against the Twins.
• Steven Kwan has scored at least one run in each of his last four appearances with the Guardians as favorites against the Twins.
• Steven Kwan has recorded at least one Single in nine of the Guardians’ last 10 home games.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last 10 home games.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Steven Kwan ranks T3rd in the league in Hits (37) this season.

Minnesota Twins Player Prop Facts

• Trevor Larnach has hit a home run in four of the Twins’ last five night games.
• Ty France has scored at least one run in each of the Twins’ last six road games against AL Central opponents.
• Bailey Ober has recorded six or more strikeouts in eight of his last nine appearances against AL Central opponents.
• Ryan Jeffers has recorded at least one Single in each of his last four road appearances against AL Central opponents.
• Jonah Bride has recorded at least one RBI in each of his last four road appearances against AL opponents.
• Jonah Bride has recorded at least one hit in each of his last 12 appearances with his team as a road underdog against AL opponents.
• Willi Castro has recorded a Double in each of his last three appearances with the Twins as underdogs against AL Central opponents.

Guardians vs Twins Prediction

This line is a bit surprising when you consider the Guardians played three games over the weekend and will have a shaken-up bullpen. Williams also has been a bit hit or miss this season, allowing 19 hits and 10 earned runs in his last 21 innings. You can get to Williams at times.

The Twins have quietly won five of their last six games and absolutely dominated the Angels in a sweep. Ober has rough numbers on the season, but that’s because of a bad season opener. In 22.1 innings in the month of April, Ober has allowed 21 hits and six runs while striking out 20. Ober has allowed one run in three of his last four starts. I’ll gladly take a shot with the Twins and the more favorable price.