Guardians vs Twins Prediction 4/30/25 MLB Picks Today

The Minnesota Twins and the Cleveland Guardians meet Wednesday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Guardians vs Twins Prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Pablo Lopez for the start here, and Lopez is 2-1 with a 2.08 ERA and 20 strikeouts this season. In his last five starts against the Guardians, Lopez is 1-2 with a 4.25 ERA and 19 strikeouts. Luis Ortiz will get the nod for the Guardians and is 2-3 with a 5.96 ERA and 31 strikeouts this season. This will be Ortiz’s first career start against the Minnesota Twins.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to bounce back from a 2-1 loss at the hands of the Guardians on Tuesday to fall to 13-17 on the year. After this series, the Twins will head on the road for a series against the Boston Red Sox.

Twins Have Four-Game Win Streak Snapped

Byron Buxton leads the Twins with 25 hits, along with 4 doubles, a team-high 6 home runs, and 17 RBIs with 6 stolen bases and a pair of triples, while Carlos Correa has 23 hits with 8 doubles, and Willi Castro has 15 hits with 6 doubles as well. Harrison Bader added 3 home runs and 13 RBIs while Matt Wallner chipped in 5 doubles and a pair of triples, while Buxton contributed a team-high 38 strikeouts as well this season. Ty France has also added 6 doubles, 3 home runs, and 18 RBIs, and Trevor Larnach chipped in 4 home runs and 14 RBIs as well this season.

Why the Minnesota Twins will win

• The Guardians have lost each of their last six games as underdogs against American League opponents following a home win.
• The Twins have won four of their last five games.
• The Guardians have failed to cover the run line in each of their last nine Wednesday night games against American League opponents.
• The Twins have covered the run line in eight of their last nine games against American League opponents.

Minnesota Twins Player Prop Facts

• Harrison Bader has hit a home run in four of his five previous appearances with his team as a road favorite against the Guardians.
• Ty France has recorded a Double in three of the Twins’ last four games against AL opponents.
• Ty France has recorded at least one RBI in each of the Twins’ last four road games against AL Central opponents.
• Ty France has scored at least one run in each of the Twins’ last eight road games against AL Central opponents.
• Pablo Lopez has recorded six or more strikeouts in 14 of his 17 previous road appearances against AL opponents that held a winning record.
• Ty France has recorded at least one Single in each of the Twins’ last four night games against AL Central opponents that held a winning record.
• Ty France has recorded at least one hit in each of the Twins’ last eight road games against AL Central opponents.
• Pablo Lopez has recorded a win in three of his last four appearances with the Twins as favorites against AL Central opponents.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their win over the Twins from Tuesday’s matchup to improve to 16-13 on the year. After this series, the Guardians will head on the road for a set against the Toronto Blue Jays.

Guardians Snap Three-Game Losing Streak

Steven Kwan leads the Guardians with 38 hits as part of a .333 batting average and 4 home runs, 5 doubles, and 15 RBIs. Kyle Manzardo has 20 hits with 3 doubles, a triple, 8 home runs, and a team-high 19 RBIs as well this year. Gabriel Arias has a team-high 6 doubles, but also has a team-high 28 strikeouts, and Manzardo has 26 strikeouts so far this season. Arias has also added 4 home runs and 11 RBIs, and Jose Ramirez has chipped in 5 home runs and 14 RBIs.

Why the Cleveland Guardians will win

• The Guardians have won each of their last seven games as underdogs against the Twins following a win.
• The Twins have lost four of their last five games as favorites against the Guardians following a loss.
• The underdogs have covered the run line in each of the last nine games between the Twins and Guardians.
• The Twins have failed to cover the run line in 12 of their last 15 games as road favorites following a loss.

Cleveland Guardians Player Prop Facts

• Brayan Rocchio has scored at least one run in four of his last five appearances with the Guardians as underdogs against the Twins.
• Steven Kwan has recorded at least one Single in 11 of his last 12 appearances with the Guardians as home underdogs against AL opponents.
• Steven Kwan has recorded at least one hit in each of his last 15 appearances with the Guardians as home underdogs.
• Austin Hedges has hit a home run in three of his last six appearances with the Guardians as underdogs against the Twins.
• Lane Thomas has recorded at least one RBI in four of his last five appearances in night games against AL Central teams that held a losing record.
• Steven Kwan ranks T4th in the league in Hits (38) this season.

Total Runs Facts

• Five of the Twins’ last six road games against AL Central opponents have gone UNDER the total runs line.
• Five of the Guardians’ last six games as underdogs have gone OVER the total runs line.

Guardians vs Twins Prediction

I’m on the Twins here. Lopez is still the staff ace in this Twins rotation, and the Twins have still been competing in a lot of recent games despite their showing on Tuesday. Luis Ortiz, for me, is the weakest link in the Guardians’ rotation, and I think the Twins can get to him, and Lopez can hold down Cleveland enough to get the win here. Give me the Twins in this one.