Guardians vs Twins Prediction 5/1/25 MLB Picks Today

The Minnesota Twins and the Cleveland Guardians meet Thursday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Guardians vs Twins Prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Simeon Woods-Richardson for the start here and Woods-Richardson is 2-2 with a 4.07 ERA and 26 strikeouts this season. In his career, Woods-Richardson is 0-1 with a 2.12 ERA and 15 strikeouts this season. Ben Lively will get the start for the Guardians here and is 1-2 with a 4.40 ERA and 23 strikeouts this season. This will be Lively’s first career start against the Twins.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to shake off a frustrating 4-2 loss at the hands of the Guardians in Wednesday’s matchup to fall to 13-18 on the year. After this series, the Twins will head on the road for a set against the Boston Red Sox.

Twins Trying To Salvage Series Split

Byron Buxton leads the Twins with 25 hits along with 4 doubles, a team-high 6 home runs and 17 RBIs with 6 stolen bases and a pair of triples while Carlos Correa has 23 hits with 8 doubles and Willi Castro has 15 hits with 6 doubles as well. Harrison Bader’s added 3 home runs and 13 RBIs while Matt Wallner’s chipped in 5 doubles and a pair of triples while Buxton’s contributed a team-high 38 strikeouts as well this season. Ty France has also added 6 doubles, 3 home runs and 18 RBIs and Trevor Larnach’s chipped in 4 home runs and 14 RBIs as well this season.

Why the Minnesota Twins will win

• The underdogs have won eight of the last 10 games between the Twins and Guardians.
• The Guardians have lost three of their last four day games against American League opponents following a win.
• The underdogs have covered the run line in each of the last 10 games between the Twins and Guardians.
• The Guardians have failed to cover the run line in five of their last six games after playing the previous day.

Minnesota Twins Player Prop Facts

• Ty France has hit a home run in three of the Twins’ last five road games against AL Central opponents.
• Ty France has scored at least one run in eight of the Twins’ last nine road games against AL Central opponents.
• Ty France has recorded at least one Single in each of the Twins’ last four games against AL Central opponents that held a winning record.
• Ty France has recorded at least one hit in each of the Twins’ last nine road games against AL Central opponents.
• Jonah Bride has recorded at least one RBI in five of his last six road appearances against AL opponents.
• Willi Castro has recorded a Double in each of his last three appearances with the Twins as underdogs against AL Central opponents.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their win over the Twins from Wednesday’s clash to improve to 17-13 on the year. After this series, the Guardians will also head on the road but for a series against the Toronto Blue Jays.

Guardians Hunting For Another Series Win At Home

Steven Kwan leads the Guardians with 38 hits as part of a .333 batting average and 4 home runs, 5 doubles and 15 RBIs. Kyle Manzardo has 20 hits with 3 doubles, a triple, 8 home runs and a team-high 19 RBIs as well this year. Gabriel Arias has a team-high 6 doubles but also has a team-high 28 strikeouts and Manzardo has 26 strikeouts so far this season. Arias has also added 4 home runs and 11 RBIs and Jose Ramirez has chipped in 5 home runs and 14 RBIs.

Why the Cleveland Guardians will win

• The Guardians have won each of their last eight day games against the Twins following a win.
• The Twins have lost each of their last six day games following a road loss.
• The Guardians have covered the run line in each of their last eight day games against the Twins following a win.
• The Twins have failed to cover the run line each of their last nine Thursday day games against AL Central opponents that held a winning record.

Cleveland Guardians Player Prop Facts

• Steven Kwan has hit a home run in three of the Guardians’ last six day games against opponents that held a losing record.
• Steven Kwan has recorded at least one RBI in three of the Guardians’ last four day games against opponents that held a losing record.
• Jose Ramirez has recorded at least one Single in each of the Guardians’ last five day games.
• Steven Kwan has scored at least one run in nine of his last 10 Thursday day appearances with the Guardians as favorites.
• Will Brennan has recorded at least one hit in each of his last eight appearances against the Twins.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Steven Kwan ranks T5th in the league in Hits (38) this season.

Total Runs Facts

• Each of the Twins’ last six day games against American League opponents have gone UNDER the total runs line.
• Three of the Guardians’ last four games against AL Central opponents have gone UNDER the total runs line.

Guardians vs Twins Prediction

I’m on the Twins in this one. I’m not the biggest fan of Simeon Woods-Richardson, but he sure beats the alternative in this spot which is backing Ben Lively, who is one of the weaker links in the Guardians’ rotation in my opinion. The Twins have to get their road issues figured out and fast, but I still think that the Twins can earn the series split here, so give me Minnesota in this one.