Guardians vs White Sox Prediction 7/10/25 MLB Picks Today

The Cleveland Guardians are visiting the Chicago White Sox on Thursday, July 10^th at the Rate Field in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Guardians vs White Sox Prediction. We will examine:

The Chicago White Sox’s recent form and player performance

The Cleveland Guardians’ recent form and player performance

Recent betting trends and streaks involving the Chicago White Sox

Recent betting trends and streaks involving the Cleveland Guardians

Recent betting trends in games played between the Cleveland Guardians vs Chicago White Sox

A summary that ties it all together and produces a favorable betting outcome for the Cleveland Guardians vs Chicago White Sox game

Chicago White Sox Preview

The Chicago White Sox have a 31-62 record this season and are sitting in last place in the AL Central. The White Sox have a 20-26 home record and are 39-49 in over/under. They are coming off a 2-1 home victory over the Blue Jays, which snapped their previous three-game losing streak. Under is 8-2 in their last 10 games, and are playing the Pirates and the Rays next.

The White Sox have a .222 batting average this season, a .296 OBP, and a .345 Slugging percentage. Chicago’s pitching staff has a 4.14 ERA and 1.40 WHIP. Lenyn Sosa leads the White Sox with 74 hits, while Miguel Vargas leads the team in RBI with 34, and he is the team’s best hitter with a team-high .220 batting average

Jonathan Cannon (R) is the projected starter for the White Sox, and he has a 3-7 record, 4.50 ERA, and 1.46 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 43-48 record this season and are sitting in 4^th place in the AL Central. The Guardians have a 23-25 road record and are 40-48 in over/under. They are coming off a 4-2 road victory over the Astros, sweeping that series 3-0. Over is 3-1 in their last 4 games, and they are playing the Orioles and the Athletics next.

The Guardians have a .224 batting average this season, .295 OBP, and .366 Slugging percentage. Cleveland’s pitching staff has a 3.97 ERA and 1.36 WHIP. Steven Kwan leads the Guardians with 101 hits, while Jose Ramirez is the team’s best hitter with a .301 batting average. He also leads the team both in RBI, with 45, and in home runs with 17.

Logan Allen (R) is the projected starting pitcher for the Guardians, and he has a 5-7 record, 4.07 ERA, and 1.43 WHIP.

Why the Chicago White Sox will win

• The underdogs have won each of the Guardians’ last three games.
• The Guardians have lost four of their last six games as favorites following a win.
• The underdogs have covered the run line in seven of the Guardians’ last eight games.
• The Guardians have failed to cover the run line in five of their last six night games against teams that held a losing record.
• The Guardians have trailed after 5 innings in four of their last five games against AL Central opponents.
• The White Sox have led after 3 innings in four of their last five games at Rate Field against AL Central opponents that held a losing record.

Why the Cleveland Guardians will win

• The White Sox have lost each of their last 16 night games against AL Central opponents that held a losing record.
• The Guardians have won each of their last seven games against the White Sox.
• The Guardians have covered the run line in each of their last seven road games after playing the previous day.
• The White Sox have failed to cover the run line in eight of their last nine home games against AL Central opponents that held a losing record.
• The Guardians have led after 3 innings in each of their last four games at Rate Field against AL Central opponents that held a losing record.
• The Guardians have won the first inning in three of their last four games against the White Sox.
• The Guardians have led after 5 innings in each of their last six road games against AL Central opponents that held a losing record.

Total Runs Facts

• Each of the Guardians’ last five games as road favorites have gone UNDER the total runs line.
• Each of the White Sox’s last four night games against AL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last four games against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Guardians’ last seven games as road favorites.

Matchup/League Facts

• The White Sox rank 30th in the league for runs scored this season (318).
• The White Sox rank 30th in the league for RBIs this season (303).
• The Guardians rank 30th in the league for hits this season (665).
• The Guardians rank 29th in the league for batting average this season (.224).

Guardians vs White Sox Prediction

The Guardians are 9-1 in their last 10 overall meetings against the White Sox, and have swept their previous series this season by 3-0 wins and a combined 10-3 score. They have won their last four visits in Chicago, and Under is 4-1-1 in their last 6 meetings.

In this Guardians vs White Sox Prediction, the Guardians are coming as -130 road favorites. The Guardians are rightfully favored, as they have a far better overall record and more road wins than the White Sox have at home. Cleveland has a better bullpen and a better offense, and Allen’s previous start against the White Sox this season was a shutout, while Cannon had 6 earned runs in his previous start against Cleveland. The value here lies with the road team at a good price, so take the Cleveland Guardians on the moneyline.