Guardians vs White Sox Prediction 9/14/25 MLB Picks Today

In this article we will formulate a Guardians vs White Sox prediction for this MLB game on Sunday, September 14th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 77-71 this year after they won the first two games in this series by scores of 4-0 and 3-1. In their game two win, Cleveland trailed 1-0 in the first inning, but took the lead in the second and never looked back. The Guardians recorded six hits in the game and they were led by Kayfus, who went 1-2 with one home run and two RBIs in the win. Cleveland started Messick, who allowed seven hits and one earned run over 6.0 innings for the win, while Smith got the save. 

Prior to this series, the Guardians won three out of four against the Royals and three out of four against the Rays. Cleveland has won eight of their last nine games and they are second in the AL Central standings. The Cleveland pitching staff has a 3.81 ERA with a 1.29 WHIP and a .243 opponent batting average, while the offense has scored 577 runs with a .225 batting average and a .296 on base percentage this season. Jose Ramirez has led Cleveland with 28 home runs and 77 RBIs, while Kyle Manzardo has added 26 home runs and 67 RBIs this year. The projected starting pitcher for Cleveland is Slade Cecconi, who is 6-6 with a 4.45 ERA and a 1.25 WHIP over 115.1 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 57-92 this season after they lost game two by a score of 3-1 on Saturday. Chicago scored in the first inning, but they went scoreless over the last eight innings for the loss. The White Sox recorded eight hits in the game and they were led by Sosa, who went 1-4 with one RBI in the loss. Chicago started Martin, who allowed five hits and two earned runs over 5.0 innings for the loss, while Ellard allowed one earned run in relief. 

Prior to this series, the White Sox won two out of three against the Rays and two out of three against the Tigers. Chicago has lost three of their last five games and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.22 ERA with a 1.36 WHIP and a .247 opponent batting average, while the offense has scored 598 runs with a .235 batting average and a .304 on base percentage this season. Lenyn Sosa has led Chicago with 20 home runs and 68 RBIs, while Andrew Benintendi has added 19 home runs and 60 RBIs this year. The projected starting pitcher for Chicago is Yoendrys Gomez, who is 3-2 with a 5.05 ERA and a 1.51 WHIP over 46.1 innings pitched this season. 

Why the Guardians will beat the White Sox

• The Guardians have won each of their last six home games against the White Sox.
• The White Sox have lost eight of their last nine games at Progressive Field.
• The Guardians have covered the run line in each of their last seven games following a win.
• The White Sox have failed to cover the run line in seven of their last eight games against AL Central opponents following a road loss.
• The White Sox have trailed after 5 innings in each of their last four road games.
• The White Sox have trailed after 3 innings in three of their last four games at Progressive Field.

Total Runs Facts

• Seven of the Guardians’ last eight games have gone UNDER the total runs line.
• Each of the White Sox’s last three games have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last eight Sunday games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Guardians’ last 10 games against AL Central opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in two of the Guardians’ last three day games against AL Central opponents that held a losing record.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Will Brennan has recorded at least one hit in each of his last six appearances with the Guardians as favorites against AL opponents.

Chicago White Sox Player Prop Facts

• Luis Robert has recorded at least one hit in 15 of his last 16 road appearances.
• Andrew Benintendi has hit a home run in two of his last three appearances after playing the previous day.

Guardians vs White Sox Prediction 

Cleveland has caught fire over the last week and they are now just 6.5 games behind Detroit in the Central. The Guardians are 40-34 at home this year, while the White Sox are 25-49 on the road. Chicago has scored just one run in this series and they are facing Cecconi, who has allowed 0, 7, 3, 2, and 6 earned runs in his last five starts. The Guardians are going against Gomez, who has allowed four earned runs in two of his last three. I don’t love Cecconi on the mound, but Cleveland is red hot right now. Take the Guardians -1.5 here.