Houston Astros vs Pittsburgh Pirates Prediction 6/3/26 MLB Picks Today

The Pittsburgh Pirates and the Houston Astros meet Wednesday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Pittsburgh Pirates vs. Houston Astros prediction.

Starting Pitching Matchup

The Pittsburgh Pirates will send out Paul Skenes for the start here and Skenes is 6-5 with a 2.89 ERA and 75 strikeouts this season. In his career, Skenes is 0-1 with a 1.29 ERA and 14 strikeouts against Houston. Spencer Arrighetti will start for Houston here and is 7-1 with a 1.34 ERA and 43 strikeouts this season. This will be Arrighetti’s first career start against the Pirates.

Pittsburgh Pirates Recap

The Pittsburgh Pirates come into this game looking to add on to their 10-6 win over Houston from Tuesday’s matchup to sit at 33-28 this season. After this series, the Pirates will head on the road for a series against the Atlanta Braves.

Pirates Win 4 In A Row

Oneil Cruz has 62 hits including 10 doubles, 14 home runs and 44 RBIs while Ryan O’Hearn has 49 hits with 6 doubles, 8 home runs and 30 RBIs this season. Nick Gonzales has 63 hits with 9 doubles and 26 RBIs while Brandon Lowe has 55 hits with 12 doubles, 15 home runs and 40 RBIs and Bryan Reynolds has 58 hits with 12 doubles, 2 triples, 6 home runs and 38 RBIs as well this season.

Houston Astros Recap

The Houston Astros come into this game looking to bounce back from their loss at the hands of Pittsburgh on Tuesday to fall to 27-35 this season. After this series, the Astros will take on the Athletics in a series at home.

Astros Drop Back-To-Back Games

Yordan Alvarez has 67 hits with 12 doubles, 21 home runs and 42 RBIs while Christian Walker has 56 hits with 10 doubles, 16 home runs and 44 RBIs on the year. Jose Altuve’s chipped in 40 hits with 10 doubles, 4 home runs and 12 RBIs and Carlos Correa has 34 hits with 8 doubles, 3 home runs and 16 RBIs. Cam Smith also has 43 hits with 8 doubles, 6 home runs and 21 RBIs. Yainer Diaz also has 24 hits with 5 doubles, 2 home runs and 14 RBIs.

Pittsburgh Pirates @ Houston Astros Betting Trends: June 3, 2026

• Probable Starting Pitcher: Spencer Arrighetti      Record this season: 7-1      ERA: 1.34
• Home Record: 3-0
• Last 5 against Pirates: –

Why the Houston Astros will win

• The Astros have won seven of their last eight games as underdogs against National League opponents following a loss.
• The Pirates have lost each of their last five night games against American League opponents following a road win.
• The Astros have covered the run line in eight of their last nine games as underdogs against National League opponents following a loss.
• The Pirates have failed to cover the run line in each of their last four night games against American League opponents following a road win.
• The Pirates have trailed after 3 innings in each of their last six night games against American League opponents.
• The Astros have led after 5 innings in each of their last four home night games.
• The Astros have won the first inning in each of their last five Wednesday home games against National League opponents.

• Probable Starting Pitcher: Paul Skenes      Record this season: 6-5      ERA: 2.89
• Road Record: 3-2
• Last 5 against Astros: 0-1

Why the Pittsburgh Pirates will win

• The Pirates have won each of their last 10 games as road favorites against American League opponents following a win.
• The Astros have lost six of their last seven home games against NL Central opponents.
• The Pirates have covered the run line in each of their last six road games against the Astros.
• The Astros have failed to cover the run line in each of their last five home games against the Pirates following a loss.
• The Pirates have led after 3 innings in three of their last four games against AL West opponents that held a losing record.
• The Pirates have led after 5 innings in seven of their last eight games as road favorites.

Total Runs Facts

• Each of the Astros’ last eight night games against NL Central opponents have gone OVER the total runs line.
• Each of the Pirates’ last seven games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last nine Wednesday games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Pirates’ last eight road games against American League opponents.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit a home run in four of the Astros’ last five night games against NL Central opponents that held a winning record.
• Jake Meyers has recorded at least one hit in each of his last 10 appearances against NL Central opponents that held a winning record.
• Yordan Alvarez ranks 2nd in the league in Home Runs (21) this season.

Pittsburgh Pirates Player Prop Facts

• Brandon Lowe has hit a home run in five of his last six appearances in night games against AL West teams that held a losing record.
• Brandon Lowe has recorded at least one hit in each of his last eight appearances against AL West opponents that held a losing record.
• Oneil Cruz ranks T3rd in the league in Steals (19) this season.

Matchup/League Facts

• The Astros rank T29th in the league for triples this season (3).
• The Astros rank 29th in the league for steals this season (22).
• The Pirates rank 2nd in the league for hits this season (539).
• The Pirates rank 2nd in the league for on-base percentage this season (.338).

Pittsburgh Pirates vs. Houston Astros Prediction

I’m on the Astros in this one. I think Paul Skenes is still the best pitcher in baseball, but the problem here is that Spencer Arrighetti has also quietly been putting together one of the best marks in baseball as well this year and the value for me is on the Astros. For as well as Skenes has been pitching, the Pirates are just 6-6 in his starts and I think Arrighetti matches here and gets the Astros the W at a nice price.