Kansas City Royals vs Toronto Blue Jays Prediction 9/21/25 MLB Picks Today

The Toronto Blue Jays and the Kansas City Royals meet Sunday in MLB action from Kauffman Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Toronto Blue Jays vs. Kansas City Royals prediction.

Starting Pitching Matchup

The Toronto Blue Jays will send out Trey Yesavage for the start here and Yesavage is 0-0 with a 1.80 ERA and 9 strikeouts this season. This will be Yesavage’s first career start against Kansas City. The Kansas City Royals will trot out Michael Wacha here and Wacha is 9-12 with a 3.79 ERA and 117 strikeouts this season. In his last five starts against the Jays, Wacha is 2-1 with a 4.28 ERA and 20 strikeouts.

Toronto Blue Jays Recap

The Toronto Blue Jays come into this game looking to bounce back from their 2-1 loss at the hands of the Royals on Saturday to slip to 89-66 this season. After this set, the Blue Jays will take on the Boston Red Sox in a crucial division series at home.

Blue Jays Drop Four Straight

George Springer has 140 hits and Bo Bichette has 181 hits with Springer adding 29 home runs, a triple, 23 doubles and 78 RBIs while Bichette has 44 doubles, 18 home runs and 94 RBIs. Andres Gimenez has added 64 hits with 9 doubles and 7 home runs and 30 RBIs this season along with 12 stolen bases. Vladimir Guerrero Jr. also has 23 homers, 33 doubles and 81 RBIs while Springer also has a .302 batting average and 104 strikeouts up to this point in the year. Addison Barger’s chipped in 30 doubles with 20 home runs and 72 RBIs and Ernie Clement’s added 33 doubles as part of his 144 hits this season.

Why the Toronto Blue Jays will win

• The Blue Jays have won each of their last four day games against AL Central opponents following a loss.
• The Royals have lost six of their last seven day games following a win.
• The Royals have failed to cover the run line in seven of their last eight day games following a win.
• The Blue Jays have covered the run line in each of their last five day games against AL Central opponents following a loss.

Toronto Blue Jays Player Prop Facts

• Daulton Varsho has hit at least one home run in eight of his last 13 appearances with the Blue Jays as road favorites.
• Bo Bichette has recorded a Double in each of his last five appearances against AL opponents that held a winning record.
• Bo Bichette has recorded at least one hit in each of his last 15 appearances with the Blue Jays as favorites against AL Central opponents.
• George Springer ranks 4th amongst qualified players for On Base Percentage (.393) this season.

Kansas City Royals Recap

The Kansas City Royals come into this game looking to add on to their win over Toronto from Saturday’s clash to climb to 78-77 this season. After this series, the Royals will head on the road for a series against the Los Angeles Angels.

Royals Looking For Huge Series Sweep

Bobby Witt Jr. has 166 hits with 41 doubles and 36 stolen bases along with 6 triples, 22 home runs and 79 RBIs while Vinnie Pasquantino has 151 hits with 27 doubles, a triple, 30 home runs and 104 RBIs. Maikel Garcia’s added 161 hits with 36 doubles, 5 triples, 16 home runs and 70 RBIs and 23 stolen bases and Salvador Perez also has 34 doubles, 28 home runs and 89 RBIs but also has 115 strikeouts so far this season.

Why the Kansas City Royals will win

• The Blue Jays have lost eight of their last nine games as road favorites against American League opponents.
• The Royals have won each of their last five games as home underdogs against the Blue Jays.
• The Blue Jays have failed to cover the run line in each of their last 11 games as road favorites against American League opponents.
• The underdogs have covered the run line in each of the Blue Jays’ last six games.

Kansas City Royals Player Prop Facts

• Michael Massey has hit a home run in three of his last four appearances against the Blue Jays.
• Michael Wacha has recorded three or more strikeouts in 22 of his last 23 appearances against AL East opponents.
• Salvador Perez has recorded at least one hit in each of the Royals’ last 13 games against the Blue Jays.
• Kyle Isbel has recorded at least one Double in three of his last four appearances against the Blue Jays.
• Bobby Witt Jr. ranks 3rd in the league in Hits (173) this season.

Total Runs Facts

• Five of the last six games between the Blue Jays and Royals at Kauffman Stadium have gone UNDER the total runs line.
• Five of the Blue Jays’ last six games against AL Central opponents have gone OVER the total runs line.

Toronto Blue Jays vs. Kansas City Royals Prediction

I’m on the Blue Jays in this one. I haven’t loved how the Blue Jays have looked offensively in this series, and Wacha already stymied the Jays in Toronto in his earlier start against them this season. However, Toronto’s in must-win mode here and the one thing about the Jays this year is they’ve rarely stayed down for extended periods of time and usually respond in key spots. Wacha’s been hit hard in some of his recent outings and Yesavage was every bit as good as advertised in his Major League debut. Give me the Blue Jays here.