LA Angels vs Toronto Blue Jays Prediction 4/22/26 MLB Picks Today

The Toronto Blue Jays and the Los Angeles Angels meet Wednesday in MLB action from Angels Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Toronto Blue Jays vs. Los Angeles Angels prediction.

Starting Pitching Matchup

The Toronto Blue Jays will send out Eric Lauer for the start here and Lauer is 1-3 with a 7.13 ERA and 16 strikeouts this season. Jose Soriano will start for the Angels here and is 5-0 with a 0.28 ERA and 39 strikeouts this season.

Toronto Blue Jays Recap

The Toronto Blue Jays come into this game looking to add on to their 4-2 win over the Angels from Tuesday’s matchup to sit at 10-13 this season. After this series, the Blue Jays will take on the Cleveland Guardians a series at home.

Blue Jays Win 3 In A Row

Andres Gimenez has 21 hits with 3 doubles, a triple, 3 home runs and 12 RBIs while Ernie Clement has 29 hits with 10 doubles and 5 RBIs. Kazuma Okamoto has 17 hits with 2 doubles, 3 home runs, 8 RBIs and a team-high 31 strikeouts while George Springer also has 4 doubles, 2 homers with 6 RBIs. Vladimir Guerrero Jr. has 30 hits with 5 doubles, 2 home runs and 12 RBIs as well. Jesus Sanchez also has 18 hits with 3 doubles, 2 home runs and 11 RBIs.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to rebound from their loss at the hands of Toronto last time out to sit at 11-14 on the year. After this series, the Angels will head on the road for a series against the Kansas City Royals.

Angels Lose 4 In A Row

Nolan Schanuel has 20 hits with 3 doubles, a pair of homers and 14 RBIs while Mike Trout’s added 20 hits with 4 doubles, 7 home runs and 16 RBIs this season. Zach Neto’s also added 23 hits with 5 doubles, 5 homers and 11 RBIs and Jo Adell has 27 hits with 3 home runs and 14 RBIs as well this season. Oswald Peraza has 19 hits with 4 doubles, 4 home runs and 8 RBIs and Jorge Soler has 17 hits with 3 doubles, 5 home runs and 19 RBIs well this season.

Toronto Blue Jays @ Los Angeles Angels Betting Trends: April 22, 2026

• Probable Starting Pitcher: Jose Soriano      Record this season: 5-0      ERA: 0.28
• Home Record: 2-0
• Last 5 against Blue Jays: 0-0

Why the Los Angeles Angels will win

• The Blue Jays have lost each of their last six day games against American League opponents following a road win.
• The Angels have won four of their last five day games against American League opponents that held a losing record.
• The Blue Jays have failed to cover the run line in each of their last six day games against American League opponents following a road win.
• The Angels have covered the run line in each of their last five day games against AL East opponents.
• The Blue Jays have trailed after 3 innings in each of their last five day games against American League opponents.
• The Blue Jays have lost the first inning in five of their last six road games against opponents that held a losing record.
• The Blue Jays have trailed after 5 innings in each of their last five day games against American League opponents.

• Probable Starting Pitcher: Eric Lauer      Record this season: 1-3      ERA: 7.13
• Road Record: 0-2
• Last 5 against Angels: 0-0

Why the Toronto Blue Jays will win

• The Blue Jays have won each of their last 10 games against the Angels following a win.
• The Angels have lost five of their last six games as favorites against American League opponents.
• The road team has covered the run line in each of the last six games between the Blue Jays and Angels.
• The Angels have failed to cover the run line in each of their last six games as favorites against American League opponents.
• The Blue Jays have led after 3 innings in each of their last five Wednesday games.
• The Angels have lost the first inning in four of their last five day games against AL East opponents that held a losing record.
• The Angels have trailed after 5 innings in four of their last five day games.

Total Runs Facts

• Seven of the Angels’ last eight games have gone UNDER the total runs line.
• Five of the Blue Jays’ last six games against AL West opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Angels’ last 11 day games against AL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Blue Jays’ last six day games against American League opponents.

Los Angeles Angels Player Prop Facts

• Jo Adell has hit a home run in four of his last five appearances with the Angels as favorites against AL East opponents.
• Mike Trout has recorded at least one hit in each of his last 19 home appearances against AL East opponents that held a losing record.
• Jose Soriano ranks T1st in the league for Wins (5) this season.

Toronto Blue Jays Player Prop Facts

• Eric Lauer has recorded a win in each of his three previous appearances in day games against AL West teams that held a losing record.
• Vladimir Guerrero Jr. has recorded at least one hit in each of the Blue Jays’ last 21 road games.
• Alejandro Kirk has hit at least one home run in three of his last four appearances against AL opponents that held a losing record.
• Vladimir Guerrero Jr. ranks 2nd amongst qualified players for Batting Average (.353) this season.

Matchup/League Facts

• The Angels rank 30th in the league for strikeouts against this season (247).
• The Angels rank 1st in the league for walks this season (114).
• The Blue Jays rank 1st in the league for strikeouts against this season (156).
• The Blue Jays rank T28th in the league for steals this season (8).

Toronto Blue Jays vs. Los Angeles Angels Prediction

I’m on the Angels in this one. The Blue Jays have been hot, but Jose Soriano has been dominant out of the gate and I’m just not interested in stepping in front of him right now even though I thinkt he Blue Jays are a team on the ascent. The Angels have themselves a stud pitcher here and I think he continues his hot start to the year. Give me the Angels.