LA Dodgers vs San Francisco Giants Prediction 9/20/25 MLB Picks Today

The San Francisco Giants and the Los Angeles Dodgers meet Saturday in MLB action from Dodger Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. Los Angeles Dodgers prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Kai-Wei Teng for the start in this one and Teng is 2-4 with a 6.41 ERA and 33 strikeouts this season. This will be Teng’s first career start against the Dodgers. Tyler Glasnow will start for the Dodgers here and is 3-3 with a 3.06 ERA and 96 strikeouts this season. In his last five starts against the Giants, Glasnow is 3-1 with a 4.05 ERA and 23 strikeouts.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to rebound from a 6-3 loss at the hands of the Dodgers on Friday to fall to 76-78 this season. After this series, the Giants will take on the St. Louis Cardinals in a series at home.

Giants Lose 7 Of Last 9

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 52 RBIs with 10 stolen bases while Heliot Ramos has 149 hits with 24 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 16 home runs and 70 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 99 hits with 21 home runs and 58 RBIs along with 20 doubles and Willy Adames has 126 hits with 20 doubles, 28 home runs and 82 RBIs of his own this season. 

Why the San Francisco Giants will win

• The Giants have won four of their last five night games against the Dodgers following a loss.
• The Dodgers have lost four of their last five Saturday night games as favorites against National League opponents.
• The Dodgers have failed to cover the run line each of their last six Saturday games against teams that held a losing record.
• The Giants have covered the run line in six of their last seven road games against teams that held a winning record.

San Francisco Giants Player Prop Facts

• Casey Schmitt has hit a home run in five of his last 13 appearances with the Giants as road underdogs against NL West opponents.
• Dominic Smith has recorded at least one hit in 20 of his last 22 appearances in night games.
• Dominic Smith has recorded a Double in three of his last four road appearances against the Dodgers.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to build on their win over the Giants from Friday’s matchup to sit at 87-67 this year. After this set, the Dodgers will take on the Arizona Diamondbacks in a series on the road.

Dodgers Win Three In A Row

Shohei Ohtani has 162 hits including 22 doubles, 51 home runs, 95 RBIs and 8 triples. Michael Conforto has 78 hits with 20 doubles while Teoscar Hernandez has 119 hits with 24 home runs, 28 doubles and 84 RBIs as well this season. Ohtani has a team-high 19 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 19 home runs and 78 RBIs as well on the year. Freddie Freeman has also logged 155 hits with a team-high 39 doubles, 21 home runs and 83 RBIs. Andy Pages also has 151 hits with 25 doubles, 25 home runs and 81 RBIs as well this season.

Why the Los Angeles Dodgers will win

• The Dodgers have won each of their last six home games against NL West opponents.
• The Giants have lost seven of their last eight games after playing the previous day.
• The Dodgers have covered the run line each of their last five games against teams that held a losing record.
• The Giants have failed to cover the run line in four of their last five games against the Dodgers following a loss.

Los Angeles Dodgers Player Prop Facts

• Mookie Betts has hit a home run in four of the Dodgers’ last five games against opponents that held a losing record.
• Tyler Glasnow has recorded eight or more strikeouts in three of his last four home appearances.
• Mookie Betts has recorded at least one hit in each of his last 11 appearances against NL West opponents that held a losing record.
• Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.619) this season.

San Francisco Giants vs. Los Angeles Dodgers Prediction

I’m on the Dodgers here. The Giants just look like they’re running out of gas and are now up against it here against Glasnow, when the Giants have been really having issues generating offense against right-handed pitching as of late. Kai-Wei Teng is just not a pitcher I’m looking to back and he’s been hit hard far more often than not this season. I’ll roll with the Dodgers in this one.