Mariners vs Astros Prediction 5/25/25 MLB Picks Today

The Seattle Mariners are visiting the Houston Astros on Sunday, May 25^th at the Daikin Park in the fourth and final game of this series, with the Astros having a 2-1 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Mariners vs Astros Prediction. We will examine:

The Houston Astros recent form and player performance

The Seattle Mariners recent form and player performance

Recent betting trends and streaks involving the Houston Astros

Recent betting trends and streaks involving the Seattle Mariners

Recent betting trends in games played between the Seattle Mariners vs Houston Astros

A summary that ties it all together and produces a favorable betting outcome for A Seattle Mariners vs Houston Astros game

Houston Astros Preview

The Houston Astros have a 27-25 record this season and are sitting on the second place of the AL West. The Astros have a 17-10 home record and 21-29 in over/under. They are coming off a 2-1 home victory the Mariners, and are 2-3 in their last 5 games. Under is 9-3 in their last 12 games, and they are playing the Athletics and the Rays next.

The Astros have a .251 batting average this season, .321 OBP and .382 slugging percentage. Houston’s pitching staff has a 3.43 ERA and 1.15 WHIP. Jeremy Pena leads the Astros with 58 hits, while Isaac Paredes leads the team in RBI with 31, adding a team-high 11 home runs. Jake Meyers is the team’s best hitter, with a .308 batting average.

Colton Gordon (L) will take the mound for the Astros, and he has a 0-0 record, 5.59 ERA and 1.45 WHIP. He has allowed 6 earned runs in 9.2 innings pitched in his two starts this season, and this will be his first career start against the Mariners.

Seattle Mariners Preview

The Seattle Mariners have a 29-22 record this season and are sitting on the first place of the AL West. The Mariners have a 16-11 road record and 27-22 in over/under They are coming off a 1-3 road defeat by the Astros, and are 6-3 in their last 9 games. Under is 9-2 in their last 11 games and they are playing the Nationals and the Twins next.

The Mariners have a .236 batting average this season, .325 OBP and .399 Slugging percentage. Seattle’s pitching staff has a 3.66 ERA and 1.31 WHIP. Cal Raleigh leads the Mariners in hits with 47, in RBI with 35, and in home runs with 17. JP Crawford is the team’s best hitter with a .260 batting average.

Luis Castillo (R) will take the mound for the Mariners, and he has a 4-3 record, 3.20 ERA and 1.26 WHIP. He has been weaker on the road with a 4.03 ERA across four road starts, and he has been in excellent form with just one earned run or less in four of his last five starts. In his previous start against the Astros this season he had a shutout performance in 5 innings pitched. Luis Castillo is 2-2 with an ERA of 3.27 and 38 strikeouts in 7 appearances against the Astros in his career.

Why the Houston Astros will win

• The underdogs have won each of the last five games between the Mariners and Astros.
• The Mariners have lost six of their last eight games as favorites.
• The underdogs have covered the run line in each of the Astros’ last seven games.
• The Mariners have failed to cover the run line in 10 of their last 11 games as favorites.
• The Astros have led after 5 innings in nine of their last 10 day games against AL West opponents.
• The Mariners have lost the first inning in three of their last four day games against AL West opponents.
• The Astros have led after 3 innings in nine of their last 10 day games against AL West opponents.

Why the Seattle Mariners will win

• The Astros have lost each of their last nine day games following a win.
• The Mariners have won each of their last six games against the Astros following a loss.
• The Astros have failed to cover the run line in each of their last nine day games following a win.
• The Mariners have covered the run line in each of their last six games at Daikin Park following a road loss.
• The Mariners have led after 5 innings in each of their last five Sunday games against the Astros.
• The Mariners have led after 3 innings in each of their last six Sunday games as road favorites.

Total Runs Facts

• Seven of the Mariners’ last eight day games as favorites have gone OVER the total runs line.
• Ten of the Astros’ last 12 games as underdogs have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last five games as favorites against AL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Astros’ last 12 games as home underdogs against American League opponents.

Matchup/League Facts

• The Astros rank 2nd in the league for opponent batting average this season (.215).
• The Astros rank 2nd in the league for hits allowed this season (362).
• The Mariners rank 2nd in the league for walks this season (205).
• The Mariners rank T28th in the league for doubles this season (65).

Mariners vs Astros Prediction

The Mariners are 6-4 in their last 10 meetings against the Astros, and are 5-3 in their last 8 visits in Houston. Over/Under is a balanced 4-4-2 in their last 10 meetings.

In this Mariners vs Astros Prediction, the Mariners are coming as -130 road favorites. The Mariners are rightfully favored in this game, as they have the better overall record, and both teams’ home/away splits are almost identical. Mariners have the clear pitching advantage in this matchup, and have a better batting average, while the Astros have a better bullpen. That is why we will focus on the first 5 innings of this game, and take the Seattle Mariners on the moneyline in the first 5 innings.