Mariners vs Astros Prediction 9/19/25 MLB Picks Today

In this article, we will formulate a Mariners vs Astros Prediction for this MLB game on Friday, September 19^th at the Daikin Park in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Preview

The Houston Astros have an 84-69 record this season and are sitting on the second place of the AL West. The Astros have a 46-32 home record and 70-77 in over/under. They are coming off a 5-2 home victory over the Rangers, and are 5-1 in their last 6 games. Over is 4-2 in their last 6 games and are playing the Athletics and the Angels next.

The Astros have a .252 batting average this season, .318 OBP and .400 slugging percentage. Houston’s pitching staff has a 3.83 ERA and 1.22 WHIP. Jose Altuve leads the Astros with 148 hits, adding a team-high 26 home runs. Jeremy Pena is the team’s best hitter with a .305 batting average, while Christian Walker leads the team in RBI with 82.

Hunter Brown (R) is the projected starting pitcher for the Astros, and he has a 12-7 record, 2.27 ERA and 1.00 WHIP.

Seattle Mariners Preview

The Seattle Mariners have an 84-69 record this season and are sitting on the second place of the AL West. The Mariners have a 36-42 road record and are 84-63 in over/under. They are coming off a 4-2 home victory over the Cardinals, and have five consecutive wins. Over is 6-3 in their last 9 games and are playing the Rockies and the Dodgers next.

The Mariners have a .244 batting average this season, .320 OBP and .419 Slugging percentage. Seattle’s pitching staff has a 3.91 ERA and 1.24 WHIP. Julio Rodriguez leads the Mariners in hits with 168, and he is the team’s best hitter with a .269 batting average. Cal Raleigh leads the team both in RBI with 118, and in home runs with 56.

Bryan Woo (R) is the projected starting pitcher for the Mariners, and he has a 14-7 record, 3.02 ERA and 0.94 WHIP.

Seattle Mariners @ Houston Astros Betting Trends: September 19, 2025

• Probable Starting Pitcher: Hunter Brown      Record this season: 12-7      ERA: 2.27
• Home Record: 5-5
• Last 5 against Mariners: 1-1

Why the Houston Astros will win

• The Mariners have lost each of their last six games as road favorites against AL West opponents following a win.
• The Astros have won each of their last five games as home underdogs against AL West opponents.
• The Mariners have failed to cover the run line in each of their last nine road games against AL West opponents following a win.
• The Astros have covered the run line each of their last seven night games against teams that held a winning record.
• The Astros have led after 3 innings in each of their last eight night games.
• The Astros have led after 5 innings in each of their last eight night games.
• The Astros have won the first inning in four of their last five home games against AL West opponents that held a winning record.

• Probable Starting Pitcher: Bryan Woo      Record this season: 14-7      ERA: 3.02
• Road Record: 4-5
• Last 5 against Astros: 1-2

Why the Seattle Mariners will win

• The favorites have won each of the Mariners’ last 11 games.
• The Astros have lost five of their last six games against the Mariners following a win.
• The favorites have covered the run line in each of the Mariners’ last five games.
• The Astros have failed to cover the run line in six of their last seven games as underdogs against the Mariners following a home win.
• The Mariners have led after 3 innings in four of their last five road games.
• The Mariners have led after 5 innings in each of their last five games as favorites.
• The Mariners have won the first inning in three of their last four games as favorites.

Total Runs Facts

• Seven of the Mariners’ last eight night games against American League opponents have gone OVER the total runs line.
• Four of the Astros’ last five home games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Astros’ last eight games as home underdogs against AL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Mariners’ last five games.

Houston Astros Player Prop Facts

• Jeremy Pena has recorded a Double in each of his last three appearances after not playing the previous day.
• Ramon Urias has recorded at least one hit in each of his last nine home appearances against AL West opponents.
• Isaac Paredes has hit a home run in four of his last seven home appearances against AL West opponents that held a winning record.
• Hunter Brown ranks 3rd amongst qualified players for Earned Run Average (2.27) this season.

Seattle Mariners Player Prop Facts

• Julio Rodriguez has hit a home run in four of the Mariners’ last five road games against AL opponents that held a winning record.
• Jorge Polanco has recorded at least one Double in eight of the Mariners’ last nine games as favorites.
• Jorge Polanco has recorded at least one hit in each of the Mariners’ last 12 games as favorites.
• Cal Raleigh ranks 1st in the league in Home Runs (56) this season.

Matchup/League Facts

• The Astros rank 1st in the league for strikeouts this season (1428).
• The Astros rank 4th in the league for opponent batting average this season (.232).
• The Mariners rank 29th in the league for doubles this season (221).
• The Mariners rank 29th in the league for triples this season (9).

Mariners vs Astros Prediction

Both teams are tied 5-5 wins in their last 10 head-to-head meetings, but the Astros are 3-1 in their last 4 meetings in Houston. Under is 3-0 in their last 3 meetings in Houston.

In this Mariners vs Astros Prediction, both teams are coming at a pickem price. Both teams have been red-hot lately, and are putting their best pitchers on the mound in Woo and Brown. Woo has been weaker on the road for the Mariners, with a 3.58 road ERA, and he has not been in the best form lately, having at least two earned runs in his last four starts. On the flip side, Brown has been red-hot lately, with a 1.44 ERA across his last five starts, and I like him to lead the Astros into a home victory in this matchup.